4-phenylbutyric acid has been researched along with Diabetes Mellitus in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Exercise induces AMPK activation and subsequent PPARδ activation, which help to reduce endoplasmic reticulum (ER) and oxidative stress, thus increasing NO bioavailability in endothelial cells and vascular tissues." | 1.46 | PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice. ( Cheang, WS; Chen, ZY; Huang, Y; Lau, CW; Ma, RC; Tian, XY; Wang, L; Wang, N; Wong, WT; Xu, A; Xu, J; Zhao, L, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheang, WS | 1 |
| Wong, WT | 1 |
| Zhao, L | 1 |
| Xu, J | 1 |
| Wang, L | 1 |
| Lau, CW | 1 |
| Chen, ZY | 1 |
| Ma, RC | 1 |
| Xu, A | 1 |
| Wang, N | 1 |
| Tian, XY | 1 |
| Huang, Y | 1 |
1 other study available for 4-phenylbutyric acid and Diabetes Mellitus
| Article | Year |
|---|---|
PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice.
Topics: Animals; Aorta; Blood Pressure; Diabetes Mellitus; Diabetic Angiopathies; Diet, High-Fat; Endoplasmi | 2017 |