4-phenylbutyric acid has been researched along with Diabetes Mellitus, Type 2 in 10 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Type 2 diabetes is a chronic inflammatory disease." | 1.46 | Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS‑1 cells. ( Cao, MM; Li, YB; Liu, GD; Liu, H; Su, Y; Yin, JJ, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lozano-Cruz, T | 1 |
| Alcarraz-Vizán, G | 2 |
| de la Mata, FJ | 1 |
| de Pablo, S | 2 |
| Ortega, P | 1 |
| Duarte, Y | 1 |
| Bravo-Moraga, F | 1 |
| González-Nilo, FD | 1 |
| Novials, A | 2 |
| Gómez, R | 1 |
| Rodríguez-Comas, J | 1 |
| Díaz-Catalán, D | 1 |
| Castaño, C | 1 |
| Moreno-Vedia, J | 1 |
| Montane, J | 1 |
| Parrizas, M | 1 |
| Servitja, JM | 1 |
| Liu, H | 1 |
| Yin, JJ | 1 |
| Cao, MM | 1 |
| Liu, GD | 1 |
| Su, Y | 1 |
| Li, YB | 1 |
| Gadallah, SH | 1 |
| Ghanem, HM | 1 |
| Abdel-Ghaffar, A | 1 |
| Metwaly, FG | 1 |
| Hanafy, LK | 1 |
| Ahmed, EK | 1 |
| Bhatta, M | 1 |
| Ma, JH | 1 |
| Wang, JJ | 1 |
| Sakowski, J | 1 |
| Zhang, SX | 1 |
| Ji, X | 1 |
| Yao, L | 1 |
| Wang, M | 1 |
| Liu, X | 1 |
| Peng, S | 1 |
| Li, K | 1 |
| Xu, M | 1 |
| Shen, N | 1 |
| Luo, L | 1 |
| Sun, C | 1 |
| Lawless, MW | 1 |
| O'Byrne, KJ | 1 |
| Gray, SG | 1 |
| Xu, TY | 1 |
| Chen, RH | 1 |
| Wang, P | 1 |
| Zhang, RY | 1 |
| Ke, SF | 1 |
| Miao, CY | 1 |
| Chan, JY | 1 |
| Luzuriaga, J | 1 |
| Bensellam, M | 1 |
| Biden, TJ | 1 |
| Laybutt, DR | 1 |
| Ozcan, U | 1 |
| Yilmaz, E | 1 |
| Ozcan, L | 1 |
| Furuhashi, M | 1 |
| Vaillancourt, E | 1 |
| Smith, RO | 1 |
| Görgün, CZ | 1 |
| Hotamisligil, GS | 1 |
1 review available for 4-phenylbutyric acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Histone deacetylase inhibitors target diabetes via chromatin remodeling or as chemical chaperones?
Topics: Acetyltransferases; Chromatin Assembly and Disassembly; Diabetes Mellitus, Type 2; Drug Delivery Sys | 2009 |
9 other studies available for 4-phenylbutyric acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Cationic Carbosilane Dendritic Systems as Promising Anti-Amyloid Agents in Type 2 Diabetes.
Topics: Amyloidosis; Animals; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Islets of Langer | 2020 |
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity.
Topics: Amyloid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal | 2021 |
Endoplasmic reticulum stress induced by lipopolysaccharide is involved in the association between inflammation and autophagy in INS‑1 cells.
Topics: Activating Transcription Factor 4; Adenine; Animals; Apoptosis; Autophagy; Caspase 1; Cell Count; Ce | 2017 |
4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Endo | 2021 |
Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Bone Marrow Cells; Cell Movement; Cell Separation; Diabetes Melli | 2015 |
Cystatin C attenuates insulin signaling transduction by promoting endoplasmic reticulum stress in hepatocytes.
Topics: Animals; Antineoplastic Agents; Cell Line; Cells, Cultured; Cystatin C; Diabetes Mellitus, Type 2; D | 2015 |
4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in β-cell gene expression and progression to diabetes.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Cytokines; Diabetes Mellitus, Type 2; Disease | 2013 |
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, | 2006 |