4-phenylbutyric acid has been researched along with Deficiency Disease, Ornithine Carbamoyltransferase in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, D | 1 |
| Shang, X | 1 |
| Qiao, Y | 1 |
| Cheng, Y | 1 |
| Yu, Z | 1 |
| Huang, X | 1 |
| Hayashi, H | 1 |
| Mizuno, T | 1 |
| Horikawa, R | 1 |
| Nagasaka, H | 1 |
| Yabuki, T | 1 |
| Takikawa, H | 1 |
| Sugiyama, Y | 1 |
1 review available for 4-phenylbutyric acid and Deficiency Disease, Ornithine Carbamoyltransferase
| Article | Year |
|---|---|
[Preliminary study of glyceryl phenylbutyrate therapy for Ornithine transcarbamylase deficiency and a literature review].
Topics: Ammonia; Child; Humans; Ornithine Carbamoyltransferase Deficiency Disease; Phenylbutyrates; Retrospe | 2023 |
2 other studies available for 4-phenylbutyric acid and Deficiency Disease, Ornithine Carbamoyltransferase
| Article | Year |
|---|---|
4-Phenylbutyrate modulates ubiquitination of hepatocanalicular MRP2 and reduces serum total bilirubin concentration.
Topics: Adult; Animals; Bilirubin; Carcinoma, Hepatocellular; Cell Line; Cell Membrane; Child, Preschool; Do | 2012 |
Sodium phenylbutyrate for urea cycle enzyme deficiencies.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Costs and Cost Analysis; Female; Humans; Infant; Liver; | 1996 |