4-phenylbutyric acid has been researched along with Decreased Muscle Tone in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Braun, D | 3 |
| Bohleber, S | 1 |
| Vatine, GD | 1 |
| Svendsen, CN | 1 |
| Schweizer, U | 3 |
3 other studies available for 4-phenylbutyric acid and Decreased Muscle Tone
| Article | Year |
|---|---|
Sodium Phenylbutyrate Rescues Thyroid Hormone Transport in Brain Endothelial-Like Cells.
Topics: Biological Transport; Brain; Humans; Mental Retardation, X-Linked; Monocarboxylic Acid Transporters; | 2022 |
Efficient Activation of Pathogenic ΔPhe501 Mutation in Monocarboxylate Transporter 8 by Chemical and Pharmacological Chaperones.
Topics: Animals; Cell Membrane; Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Dogs; Genistein; Iodine | 2015 |
The Chemical Chaperone Phenylbutyrate Rescues MCT8 Mutations Associated With Milder Phenotypes in Patients With Allan-Herndon-Dudley Syndrome.
Topics: Animals; Antineoplastic Agents; Chlorocebus aethiops; Dogs; Drug Evaluation, Preclinical; Genistein; | 2017 |