4-phenylbutyric acid has been researched along with Crohn Disease in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Powell, N | 1 |
| Pantazi, E | 1 |
| Pavlidis, P | 1 |
| Tsakmaki, A | 1 |
| Li, K | 1 |
| Yang, F | 1 |
| Parker, A | 1 |
| Pin, C | 1 |
| Cozzetto, D | 1 |
| Minns, D | 1 |
| Stolarczyk, E | 1 |
| Saveljeva, S | 1 |
| Mohamed, R | 1 |
| Lavender, P | 1 |
| Afzali, B | 1 |
| Digby-Bell, J | 1 |
| Tjir-Li, T | 1 |
| Kaser, A | 1 |
| Friedman, J | 1 |
| MacDonald, TT | 1 |
| Bewick, GA | 1 |
| Lord, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observer-Blinded, Placebo-Controlled, Multiple-Ascending, Dose-Escalation Study to Explore the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Repeat Intravenous Administrations of UTTR1147A in Healthy Volunteers and Patients With Ulcer[NCT02749630] | Phase 1 | 70 participants (Actual) | Interventional | 2016-04-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-phenylbutyric acid and Crohn Disease
| Article | Year |
|---|---|
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Survival; Chronic Disease; Colitis; Colon; Crohn Dis | 2020 |