4-phenylbutyric acid has been researched along with Craniofacial Abnormalities in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Craniofacial Abnormalities: Congenital structural deformities, malformations, or other abnormalities of the cranium and facial bones.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, WCW | 1 |
| Tsang, KY | 1 |
| Cheng, YW | 1 |
| Ng, VCW | 1 |
| Chik, H | 1 |
| Tan, ZJ | 1 |
| Boot-Handford, R | 1 |
| Boyde, A | 1 |
| Cheung, KMC | 1 |
| Cheah, KSE | 1 |
| Chan, D | 1 |
1 other study available for 4-phenylbutyric acid and Craniofacial Abnormalities
| Article | Year |
|---|---|
Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Bone and Bones; Bone Morphogenetic Proteins; Bone Rem | 2017 |