4-phenylbutyric acid has been researched along with Corneal Dystrophies in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Choi, SI | 1 |
| Lee, E | 1 |
| Jeong, JB | 1 |
| Akuzum, B | 1 |
| Maeng, YS | 1 |
| Kim, TI | 1 |
| Kim, EK | 1 |
1 other study available for 4-phenylbutyric acid and Corneal Dystrophies
| Article | Year |
|---|---|
4-Phenylbutyric acid reduces mutant-TGFBIp levels and ER stress through activation of ERAD pathway in corneal fibroblasts of granular corneal dystrophy type 2.
Topics: Apoptosis; Cells, Cultured; Cornea; Corneal Dystrophies, Hereditary; Dose-Response Relationship, Dru | 2016 |