4-phenylbutyric acid has been researched along with Colorectal Neoplasms in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, L | 1 |
| Ma, L | 1 |
| Liu, C | 1 |
| Lei, Y | 1 |
| Tang, N | 1 |
| Huang, Y | 1 |
| Huang, G | 1 |
| Li, D | 1 |
| Wang, Q | 1 |
| Liu, G | 1 |
| Tang, M | 1 |
| Jing, Z | 1 |
| Deng, Y | 1 |
| Tanaka, T | 1 |
| Kojima, K | 1 |
| Yokota, K | 1 |
| Tanaka, Y | 1 |
| Ooizumi, Y | 1 |
| Ishii, S | 1 |
| Nishizawa, N | 1 |
| Yokoi, K | 1 |
| Ushiku, H | 1 |
| Kikuchi, M | 1 |
| Kojo, K | 1 |
| Minatani, N | 1 |
| Katoh, H | 1 |
| Sato, T | 1 |
| Nakamura, T | 1 |
| Sawanobori, M | 1 |
| Watanabe, M | 1 |
| Yamashita, K | 1 |
2 other studies available for 4-phenylbutyric acid and Colorectal Neoplasms
| Article | Year |
|---|---|
ERp29 counteracts the suppression of malignancy mediated by endoplasmic reticulum stress and promotes the metastasis of colorectal cancer.
Topics: Animals; Colorectal Neoplasms; Cullin Proteins; Culture Media, Conditioned; Endoplasmic Reticulum St | 2019 |
Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.
Topics: Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Biomarkers, Tumor; Colorectal N | 2019 |