4-phenylbutyric acid has been researched along with Colonic Neoplasms in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Colonic Neoplasms: Tumors or cancer of the COLON.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halaburková, A | 1 |
| Jendželovský, R | 1 |
| Kovaľ, J | 1 |
| Herceg, Z | 1 |
| Fedoročko, P | 1 |
| Ghantous, A | 1 |
| Kusaczuk, M | 1 |
| Bartoszewicz, M | 1 |
| Cechowska-Pasko, M | 1 |
| Lea, MA | 1 |
| Shareef, A | 1 |
| Sura, M | 1 |
| desBordes, C | 1 |
1 review available for 4-phenylbutyric acid and Colonic Neoplasms
| Article | Year |
|---|---|
Phenylbutyric Acid: simple structure - multiple effects.
Topics: Animals; Apoptosis; Colonic Neoplasms; Humans; Neurodegenerative Diseases; Phenylbutyrates | 2015 |
2 other studies available for 4-phenylbutyric acid and Colonic Neoplasms
| Article | Year |
|---|---|
Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of
Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Chromatin; Colonic Neoplasms; Cyclin-Dependent | 2017 |
Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules.
Topics: Acetylation; Animals; Apoptosis; Cell Division; Cell Line; Colonic Neoplasms; Histones; Humans; Leuk | 2004 |