4-phenylbutyric acid has been researched along with Cognitive Decline in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human neurodegenerative tauopathies exhibit pathological tau aggregates in the brain along with diverse clinical features including cognitive and motor dysfunction." | 1.43 | Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate. ( Bondulich, MK; Brion, JP; Guo, T; Hanger, DP; Hortobagyi, T; Manion, J; Meehan, C; Mitchell, JC; Noble, W; Rodriguez Martin, T; Stygelbout, V; Yankova, N, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Ryu, YK | 1 |
| Park, HY | 1 |
| Go, J | 1 |
| Choi, DH | 1 |
| Choi, YK | 1 |
| Rhee, M | 1 |
| Lee, CH | 1 |
| Kim, KS | 1 |
| Kong, FJ | 1 |
| Ma, LL | 1 |
| Guo, JJ | 1 |
| Xu, LH | 1 |
| Li, Y | 1 |
| Qu, S | 1 |
| Bondulich, MK | 1 |
| Guo, T | 1 |
| Meehan, C | 1 |
| Manion, J | 1 |
| Rodriguez Martin, T | 1 |
| Mitchell, JC | 1 |
| Hortobagyi, T | 1 |
| Yankova, N | 1 |
| Stygelbout, V | 1 |
| Brion, JP | 1 |
| Noble, W | 1 |
| Hanger, DP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 4-phenylbutyric acid and Cognitive Decline
| Article | Year |
|---|---|
Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism.
Topics: Animals; Antineoplastic Agents; Autism Spectrum Disorder; Brain; Cognitive Dysfunction; Disease Mode | 2021 |
Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice.
Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Cognitive Dysfunction; Diabetes Mellitus, Experiment | 2018 |
Tauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate.
Topics: Animals; Behavior, Animal; Cognitive Dysfunction; Disease Models, Animal; Female; Humans; Male; Mice | 2016 |