4-phenylbutyric acid has been researched along with Chronic Illness in 6 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Experimental allergic encephalomyelitis (EAE) is the animal model for multiple sclerosis." | 1.32 | Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps. ( Banik, NL; Dasgupta, S; Jana, M; Pahan, K; Zhou, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Powell, N | 1 |
| Pantazi, E | 1 |
| Pavlidis, P | 1 |
| Tsakmaki, A | 1 |
| Li, K | 1 |
| Yang, F | 1 |
| Parker, A | 1 |
| Pin, C | 1 |
| Cozzetto, D | 1 |
| Minns, D | 1 |
| Stolarczyk, E | 1 |
| Saveljeva, S | 1 |
| Mohamed, R | 1 |
| Lavender, P | 1 |
| Afzali, B | 1 |
| Digby-Bell, J | 1 |
| Tjir-Li, T | 1 |
| Kaser, A | 1 |
| Friedman, J | 1 |
| MacDonald, TT | 1 |
| Bewick, GA | 1 |
| Lord, GM | 1 |
| Jangra, A | 1 |
| Sriram, CS | 1 |
| Dwivedi, S | 1 |
| Gurjar, SS | 1 |
| Hussain, MI | 1 |
| Borah, P | 1 |
| Lahkar, M | 1 |
| Jain, K | 1 |
| Suryakumar, G | 1 |
| Ganju, L | 1 |
| Singh, SB | 1 |
| Mukai, S | 1 |
| Ogawa, Y | 1 |
| Urano, F | 1 |
| Kudo-Saito, C | 1 |
| Kawakami, Y | 1 |
| Tsubota, K | 1 |
| Dromparis, P | 1 |
| Paulin, R | 1 |
| Stenson, TH | 1 |
| Haromy, A | 1 |
| Sutendra, G | 1 |
| Michelakis, ED | 1 |
| Dasgupta, S | 1 |
| Zhou, Y | 1 |
| Jana, M | 1 |
| Banik, NL | 1 |
| Pahan, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Observer-Blinded, Placebo-Controlled, Multiple-Ascending, Dose-Escalation Study to Explore the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Repeat Intravenous Administrations of UTTR1147A in Healthy Volunteers and Patients With Ulcer[NCT02749630] | Phase 1 | 70 participants (Actual) | Interventional | 2016-04-11 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for 4-phenylbutyric acid and Chronic Illness
| Article | Year |
|---|---|
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Cell Survival; Chronic Disease; Colitis; Colon; Crohn Dis | 2020 |
5 other studies available for 4-phenylbutyric acid and Chronic Illness
| Article | Year |
|---|---|
Sodium Phenylbutyrate and Edaravone Abrogate Chronic Restraint Stress-Induced Behavioral Deficits: Implication of Oxido-Nitrosative, Endoplasmic Reticulum Stress Cascade, and Neuroinflammation.
Topics: Animals; Antipyrine; Chronic Disease; Depression; Dose-Response Relationship, Drug; Edaravone; Endop | 2017 |
Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1α.
Topics: Altitude; Animals; Apoptosis; Apoptosis Regulatory Proteins; Chronic Disease; Cytoprotection; Diseas | 2016 |
Novel Treatment of Chronic Graft-Versus-Host Disease in Mice Using the ER Stress Reducer 4-Phenylbutyric Acid.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chronic Disease; Disease Models, Animal; Endoplasmi | 2017 |
Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.
Topics: Activating Transcription Factor 6; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Ch | 2013 |
Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps.
Topics: Acute Disease; Administration, Oral; Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Stero | 2003 |