4-phenylbutyric acid has been researched along with Cholestasis in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van der Velden, LM | 1 |
| Stapelbroek, JM | 1 |
| Krieger, E | 1 |
| van den Berghe, PV | 1 |
| Berger, R | 1 |
| Verhulst, PM | 1 |
| Holthuis, JC | 1 |
| Houwen, RH | 1 |
| Klomp, LW | 1 |
| van de Graaf, SF | 1 |
| Gautherot, J | 1 |
| Durand-Schneider, AM | 1 |
| Delautier, D | 1 |
| Delaunay, JL | 1 |
| Rada, A | 1 |
| Gabillet, J | 1 |
| Housset, C | 1 |
| Maurice, M | 1 |
| Aït-Slimane, T | 1 |
2 other studies available for 4-phenylbutyric acid and Cholestasis
| Article | Year |
|---|---|
Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate.
Topics: Adenosine Triphosphatases; Cells, Cultured; Cholestasis; Membrane Proteins; Mutation, Missense; Phen | 2010 |
Effects of cellular, chemical, and pharmacological chaperones on the rescue of a trafficking-defective mutant of the ATP-binding cassette transporter proteins ABCB1/ABCB4.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily | 2012 |