4-phenylbutyric acid has been researched along with Chemical and Drug Induced Liver Injury in 11 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acetaminophen (APAP) overdose induces severe oxidative stress followed by hepatocyte apoptosis/necrosis." | 3.85 | Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress. ( Aoyama, T; Arai, K; Ikejima, K; Kon, K; Kusama, H; Uchiyama, A; Watanabe, S; Yamashina, S, 2017) |
| " Discontinuation of rifampin therapy, which had been used to treat pruritus, resulted in reversible severe acute liver injury that was potentially the result of phenylacetate toxicity." | 3.83 | Possible Phenylacetate Hepatotoxicity During 4-Phenylbutyrate Therapy of Byler Disease. ( Morris, A; Shneider, BL; Vockley, J, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 11 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Suzuki, M | 1 |
| Kon, K | 2 |
| Ikejima, K | 2 |
| Arai, K | 2 |
| Uchiyama, A | 2 |
| Aoyama, T | 2 |
| Yamashina, S | 2 |
| Ueno, T | 1 |
| Watanabe, S | 2 |
| Wang, S | 1 |
| Luan, J | 1 |
| Lv, X | 1 |
| Shimizu, D | 1 |
| Ishitsuka, Y | 1 |
| Miyata, K | 1 |
| Tomishima, Y | 1 |
| Kondo, Y | 1 |
| Irikura, M | 1 |
| Iwawaki, T | 1 |
| Oike, Y | 1 |
| Irie, T | 1 |
| Qi, J | 1 |
| Chen, X | 3 |
| Zhang, C | 2 |
| Tao, L | 2 |
| He, W | 1 |
| Wang, J | 2 |
| Li, J | 2 |
| Xu, D | 1 |
| Yan, S | 1 |
| Zhang, H | 1 |
| Zheng, F | 1 |
| Dai, J | 1 |
| Shneider, BL | 1 |
| Morris, A | 1 |
| Vockley, J | 1 |
| Kusama, H | 1 |
| Guo, HL | 1 |
| Hassan, HM | 1 |
| Ding, PP | 1 |
| Wang, SJ | 1 |
| Wang, T | 1 |
| Sun, LX | 1 |
| Zhang, LY | 1 |
| Jiang, ZZ | 1 |
| Wang, JQ | 1 |
| Zhang, ZH | 1 |
| Liu, XQ | 1 |
| Xu, YB | 1 |
| Wang, H | 1 |
| Xu, DX | 1 |
1 review available for 4-phenylbutyric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
10 other studies available for 4-phenylbutyric acid and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-A
Topics: Animals; Apoptosis; Binge Drinking; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1; | 2019 |
Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re | 2019 |
Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
Topics: Acetaminophen; Alanine Transaminase; Ammonia; Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Pro | 2014 |
[Effects of 4-phenylbutyric acid on carbon tetrachloride-induced acute liver injury in mice].
Topics: Alanine Transaminase; Animals; Apoptosis; Carbon Tetrachloride; Chemical and Drug Induced Liver Inju | 2015 |
Perfluorooctanoic acid exposure induces endoplasmic reticulum stress in the liver and its effects are ameliorated by 4-phenylbutyrate.
Topics: Animals; Apoptosis; Caprylates; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress | 2015 |
Possible Phenylacetate Hepatotoxicity During 4-Phenylbutyrate Therapy of Byler Disease.
Topics: Antineoplastic Agents; Bilirubin; Chemical and Drug Induced Liver Injury; Child, Preschool; Cholesta | 2016 |
Sodium 4-phenylbutyric acid prevents murine acetaminophen hepatotoxicity by minimizing endoplasmic reticulum stress.
Topics: Acetaminophen; Animals; Apoptosis; bcl-2-Associated X Protein; Chemical and Drug Induced Liver Injur | 2017 |
Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2α-ATF4-CHOP pathway.
Topics: Activating Transcription Factor 4; Alanine Transaminase; Animals; Apoptosis; Aspartate Aminotransfer | 2017 |
Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Endoplasmic Reticulum Stress; | 2013 |