4-phenylbutyric acid has been researched along with Chemical and Drug Induced Liver Injury, Chronic in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Chemical and Drug Induced Liver Injury, Chronic: Liver disease lasting six months or more, caused by an adverse effect of a drug or chemical. The adverse effect may be caused by drugs, drug metabolites, chemicals from the environment, or an idiosyncratic response.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, J | 1 |
| Wu, H | 1 |
| Tang, X | 1 |
| Chen, L | 1 |
1 other study available for 4-phenylbutyric acid and Chemical and Drug Induced Liver Injury, Chronic
| Article | Year |
|---|---|
4-Phenylbutyrate protects against rifampin-induced liver injury via regulating MRP2 ubiquitination through inhibiting endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury, Chronic; Cytoprotection; Endoplasmic Ret | 2022 |