4-phenylbutyric acid has been researched along with Cell Transformation, Neoplastic in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramadori, G | 1 |
| Konstantinidou, G | 1 |
| Venkateswaran, N | 1 |
| Biscotti, T | 1 |
| Morlock, L | 1 |
| Galié, M | 1 |
| Williams, NS | 1 |
| Luchetti, M | 1 |
| Santinelli, A | 1 |
| Scaglioni, PP | 1 |
| Coppari, R | 1 |
| Chung, YL | 1 |
| Lee, MY | 1 |
| Pui, NN | 1 |
2 other studies available for 4-phenylbutyric acid and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Diet; Down-Regulation; Doxycycline; Endo | 2015 |
Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetylation; Administration, Oral; Animals; Antineoplastic Agents; | 2009 |