4-phenylbutyric acid has been researched along with Cataract in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, S | 1 |
| Yang, J | 1 |
| Wang, M | 1 |
| Zheng, D | 1 |
| Liu, Y | 1 |
| Jara, O | 1 |
| Minogue, PJ | 2 |
| Berthoud, VM | 2 |
| Beyer, EC | 2 |
| Gong, B | 1 |
| Zhang, LY | 1 |
| Lam, DS | 1 |
| Pang, CP | 1 |
| Yam, GH | 1 |
| Guo, J | 1 |
| Williamson, EK | 1 |
| Xu, X | 1 |
| Ebihara, L | 1 |
| Mulhern, ML | 1 |
| Madson, CJ | 1 |
| Kador, PF | 1 |
| Randazzo, J | 1 |
| Shinohara, T | 1 |
5 other studies available for 4-phenylbutyric acid and Cataract
| Article | Year |
|---|---|
Endoplasmic reticulum stress regulates epithelial‑mesenchymal transition in human lens epithelial cells.
Topics: Cataract; Cell Line; Endoplasmic Reticulum Stress; Epithelial Cells; Epithelial-Mesenchymal Transiti | 2020 |
Chemical chaperone treatment improves levels and distributions of connexins in Cx50D47A mouse lenses.
Topics: Animals; Antineoplastic Agents; Cataract; Cells, Cultured; Connexins; Female; Gene Expression Regula | 2018 |
Sodium 4-phenylbutyrate ameliorates the effects of cataract-causing mutant gammaD-crystallin in cultured cells.
Topics: Animals; Apoptosis; Cataract; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; gam | 2010 |
Loss of function and impaired degradation of a cataract-associated mutant connexin50.
Topics: Animals; Cataract; Cell Line; Connexins; Electrophysiology; Eye Proteins; HeLa Cells; Humans; Immuno | 2003 |
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats.
Topics: Animals; Body Weight; Cataract; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; | 2007 |