4-phenylbutyric acid has been researched along with Cardiovascular Stroke in 6 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is a potent predictor of progression in patients and is often accompanied by inflammation and oxidative stress; however, the mechanisms involved in these alterations are not well established." | 1.62 | Role of endoplasmic reticulum stress in renal damage after myocardial infarction. ( Cachofeiro, V; de la Fuente-Chávez, L; Delgado-Valero, B; Islas, F; Luaces, M; Martínez-Martínez, E; Ramchandani, B; Romero-Miranda, A; Visitación Bartolomé, M, 2021) |
| "Sulfur dioxide has recently been found to be produced endogenously in the cardiovascular system and have important positive biological effects." | 1.37 | Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress. ( Du, JB; Huang, XM; Jin, HF; Li, XY; Ochs, T; Tang, CS; Wang, XB, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q | 1 |
| Thompson, J | 1 |
| Hu, Y | 1 |
| Lesnefsky, EJ | 1 |
| Delgado-Valero, B | 1 |
| de la Fuente-Chávez, L | 1 |
| Romero-Miranda, A | 1 |
| Visitación Bartolomé, M | 1 |
| Ramchandani, B | 1 |
| Islas, F | 1 |
| Luaces, M | 1 |
| Cachofeiro, V | 1 |
| Martínez-Martínez, E | 1 |
| Guo, J | 1 |
| Zhu, J | 1 |
| Ma, L | 1 |
| Shi, H | 1 |
| Hu, J | 1 |
| Zhang, S | 1 |
| Hou, L | 1 |
| Xu, F | 1 |
| An, Y | 1 |
| Yu, H | 1 |
| Ge, J | 1 |
| Luo, T | 1 |
| Kim, JK | 1 |
| Chen, B | 1 |
| Abdel-Latif, A | 1 |
| Kitakaze, M | 1 |
| Yan, L | 1 |
| Takatori, O | 1 |
| Usui, S | 1 |
| Okajima, M | 1 |
| Kaneko, S | 1 |
| Ootsuji, H | 1 |
| Takashima, SI | 1 |
| Kobayashi, D | 1 |
| Murai, H | 1 |
| Furusho, H | 1 |
| Takamura, M | 1 |
| Wang, XB | 1 |
| Huang, XM | 1 |
| Ochs, T | 1 |
| Li, XY | 1 |
| Jin, HF | 1 |
| Tang, CS | 1 |
| Du, JB | 1 |
6 other studies available for 4-phenylbutyric acid and Cardiovascular Stroke
| Article | Year |
|---|---|
Reversing mitochondrial defects in aged hearts: role of mitochondrial calpain activation.
Topics: Age Factors; Animals; Calpain; Cysteine Proteinase Inhibitors; Dipeptides; Disease Models, Animal; E | 2022 |
Role of endoplasmic reticulum stress in renal damage after myocardial infarction.
Topics: Adult; Animals; Cells, Cultured; Disease Models, Animal; Endoplasmic Reticulum Stress; Female; Fibro | 2021 |
Chronic Kidney Disease Exacerbates Myocardial Ischemia Reperfusion Injury: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Ret | 2018 |
Attenuation of ER stress prevents post-infarction-induced cardiac rupture and remodeling by modulating both cardiac apoptosis and fibrosis.
Topics: Animals; Animals, Newborn; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Cell Surviva | 2015 |
Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response.
Topics: Animals; Apoptosis; Disease Models, Animal; Gene Expression Regulation; Male; Mice, Inbred C57BL; My | 2017 |
Effect of sulfur dioxide preconditioning on rat myocardial ischemia/reperfusion injury by inducing endoplasmic reticulum stress.
Topics: Animals; Apoptosis; Caspase 12; Creatine Kinase; Dithiothreitol; Endoplasmic Reticulum; Heart; Heat- | 2011 |