4-phenylbutyric acid has been researched along with Carcinoma, Pancreatic Ductal in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Welsch, L | 1 |
| Welsch, T | 1 |
| Dovzhanskiy, DI | 1 |
| Felix, K | 1 |
| Giese, NA | 1 |
| Krysko, DV | 1 |
| Werner, J | 1 |
| Ammerpohl, O | 1 |
| Trauzold, A | 1 |
| Schniewind, B | 1 |
| Griep, U | 1 |
| Pilarsky, C | 1 |
| Grutzmann, R | 1 |
| Saeger, HD | 1 |
| Janssen, O | 1 |
| Sipos, B | 1 |
| Kloppel, G | 1 |
| Kalthoff, H | 1 |
2 other studies available for 4-phenylbutyric acid and Carcinoma, Pancreatic Ductal
| Article | Year |
|---|---|
Impact of the histone deacetylase inhibitor 4-phenylbutyrate on the clearance of apoptotic pancreatic carcinoma cells by human macrophages.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Carcinoma, Pancreatic Ductal; Cel | 2012 |
Complementary effects of HDAC inhibitor 4-PB on gap junction communication and cellular export mechanisms support restoration of chemosensitivity of PDAC cells.
Topics: Anthracenes; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Pancreatic Ductal | 2007 |