4-phenylbutyric acid has been researched along with Carcinogenesis in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Carcinogenesis: The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, its role in hepatocarcinogenesis remained unknown." | 5.62 | 4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α. ( Cao, QQ; Chen, C; Chen, SZ; Chen, XF; Dong, YP; Fan, ZC; Ling, Y; Miao, YS; Monga, SPS; Song, YT; Tang, JJ; Tao, JY; Wang, HY; Wen, W; Yu, H; Yu, LX, 2021) |
| "However, its role in hepatocarcinogenesis remained unknown." | 1.62 | 4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α. ( Cao, QQ; Chen, C; Chen, SZ; Chen, XF; Dong, YP; Fan, ZC; Ling, Y; Miao, YS; Monga, SPS; Song, YT; Tang, JJ; Tao, JY; Wang, HY; Wen, W; Yu, H; Yu, LX, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, SZ | 1 |
| Ling, Y | 1 |
| Yu, LX | 1 |
| Song, YT | 1 |
| Chen, XF | 1 |
| Cao, QQ | 1 |
| Yu, H | 1 |
| Chen, C | 1 |
| Tang, JJ | 1 |
| Fan, ZC | 1 |
| Miao, YS | 1 |
| Dong, YP | 1 |
| Tao, JY | 1 |
| Monga, SPS | 1 |
| Wen, W | 1 |
| Wang, HY | 1 |
1 other study available for 4-phenylbutyric acid and Carcinogenesis
| Article | Year |
|---|---|
4-phenylbutyric acid promotes hepatocellular carcinoma via initiating cancer stem cells through activation of PPAR-α.
Topics: Animals; Carcinogenesis; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Mice; Mice, Inbred C57BL; | 2021 |