4-phenylbutyric acid has been researched along with Cancer of Prostate in 6 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Complex mechanisms of prostate cancer progression prompt to novel therapeutic strategies concerning a combination of drugs or of single molecules able to interact with more crucial targets." | 1.37 | Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells. ( Bernardini, R; Fiorito, J; Marrazzo, A; Pasquinucci, L; Prezzavento, O; Ronsisvalle, G; Ronsisvalle, S; Scoto, GM; Zappalà, L, 2011) |
| "Inhibition of NF-κB in prostate cancer cells undergoing Tg-mediated ER stress by BAY 11-7082 abrogates Lcn2 upregulation." | 1.37 | ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner. ( Almanza, G; Mahadevan, NR; Pérez, AF; Rodvold, J; Wheeler, MC; Zanetti, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marrazzo, A | 1 |
| Fiorito, J | 1 |
| Zappalà, L | 1 |
| Prezzavento, O | 1 |
| Ronsisvalle, S | 1 |
| Pasquinucci, L | 1 |
| Scoto, GM | 1 |
| Bernardini, R | 1 |
| Ronsisvalle, G | 1 |
| Saito, Y | 1 |
| Friedman, JM | 1 |
| Chihara, Y | 1 |
| Egger, G | 1 |
| Chuang, JC | 1 |
| Liang, G | 1 |
| Mahadevan, NR | 1 |
| Rodvold, J | 1 |
| Almanza, G | 1 |
| Pérez, AF | 1 |
| Wheeler, MC | 1 |
| Zanetti, M | 1 |
| Lea, MA | 1 |
| Shareef, A | 1 |
| Sura, M | 1 |
| desBordes, C | 1 |
| Carducci, MA | 1 |
| Gilbert, J | 1 |
| Bowling, MK | 1 |
| Noe, D | 1 |
| Eisenberger, MA | 1 |
| Sinibaldi, V | 1 |
| Zabelina, Y | 1 |
| Chen, TL | 1 |
| Grochow, LB | 1 |
| Donehower, RC | 1 |
| Smigel, K | 1 |
1 trial available for 4-phenylbutyric acid and Cancer of Prostate
| Article | Year |
|---|---|
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
Topics: Adult; Antineoplastic Agents; Chromatography, High Pressure Liquid; Disorders of Excessive Somnolenc | 2001 |
5 other studies available for 4-phenylbutyric acid and Cancer of Prostate
| Article | Year |
|---|---|
Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Guinea Pigs; Haloperidol; Histone Deacetylase Inhibit | 2011 |
Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.
Topics: Antineoplastic Agents; Azacitidine; Calcium-Binding Proteins; Cell Line, Tumor; Decitabine; EGF Fami | 2009 |
ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner.
Topics: Acute-Phase Proteins; Adenocarcinoma; Animals; Cell Line, Tumor; Endoplasmic Reticulum; Gene Express | 2011 |
Induction of histone acetylation and inhibition of growth by phenyl alkanoic acids and structurally related molecules.
Topics: Acetylation; Animals; Apoptosis; Cell Division; Cell Line; Colonic Neoplasms; Histones; Humans; Leuk | 2004 |
Non-toxic drug being tested to treat cancer and anemias.
Topics: Anemia; Brain Neoplasms; Glutamine; Humans; Male; Phenylacetates; Phenylbutyrates; Prostatic Neoplas | 1992 |