4-phenylbutyric acid has been researched along with Cancer of Lung in 7 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paraquat (PQ) is a widely used herbicide in the world despite being highly toxic to humans." | 1.48 | Paraquat toxicity is attenuated by 4-phenylbutyrate-induced phosphorylation of ERK2 via PI3K in A549 cells. ( Asari, M; Doi, H; Horioka, K; Hoshina, C; Isozaki, S; Matsubara, K; Okuda, K; Omura, T; Shimizu, K; Shiono, H; Tanaka, H; Yamada, H, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, SY | 1 |
| Hong, EH | 1 |
| Jeong, JY | 1 |
| Cho, J | 1 |
| Seo, JH | 1 |
| Ko, HJ | 1 |
| Cho, HJ | 1 |
| Ge, G | 1 |
| Yan, Y | 1 |
| Cai, H | 1 |
| Hoshina, C | 1 |
| Omura, T | 1 |
| Okuda, K | 1 |
| Tanaka, H | 1 |
| Asari, M | 1 |
| Isozaki, S | 1 |
| Horioka, K | 1 |
| Yamada, H | 1 |
| Doi, H | 1 |
| Shiono, H | 1 |
| Matsubara, K | 1 |
| Shimizu, K | 1 |
| Zhu, M | 1 |
| Jiang, Y | 1 |
| Wu, H | 1 |
| Shi, W | 1 |
| Lu, G | 1 |
| Cong, D | 1 |
| Liu, K | 1 |
| Song, S | 1 |
| Ren, J | 1 |
| Ramadori, G | 1 |
| Konstantinidou, G | 1 |
| Venkateswaran, N | 1 |
| Biscotti, T | 1 |
| Morlock, L | 1 |
| Galié, M | 1 |
| Williams, NS | 1 |
| Luchetti, M | 1 |
| Santinelli, A | 1 |
| Scaglioni, PP | 1 |
| Coppari, R | 1 |
| Jin, X | 1 |
| Wu, N | 1 |
| Dai, J | 1 |
| Li, Q | 1 |
| Xiao, X | 1 |
| Zhang, X | 1 |
| Wei, L | 1 |
| Yang, Y | 1 |
| Yu, Q | 1 |
7 other studies available for 4-phenylbutyric acid and Cancer of Lung
| Article | Year |
|---|---|
Esterase-sensitive cleavable histone deacetylase inhibitor-coupled hyaluronic acid nanoparticles for boosting anticancer activities against lung adenocarcinoma.
Topics: A549 Cells; Adenocarcinoma of Lung; Animals; Apoptosis; Esterases; Female; Histone Deacetylase Inhib | 2019 |
Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer Cells.
Topics: Acetylcysteine; Activating Transcription Factor 4; Apoptosis; Caspases, Initiator; Cell Line, Tumor; | 2017 |
Paraquat toxicity is attenuated by 4-phenylbutyrate-induced phosphorylation of ERK2 via PI3K in A549 cells.
Topics: A549 Cells; Adenocarcinoma; Cell Survival; Cytoprotection; Herbicides; Humans; Lung Neoplasms; Mitog | 2018 |
Gambogic Acid Shows Anti-Proliferative Effects on Non-Small Cell Lung Cancer (NSCLC) Cells by Activating Reactive Oxygen Species (ROS)-Induced Endoplasmic Reticulum (ER) Stress-Mediated Apoptosis.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Survival; China; Endoplasmic Reticulum C | 2019 |
Diet-induced unresolved ER stress hinders KRAS-driven lung tumorigenesis.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Diet; Down-Regulation; Doxycycline; Endo | 2015 |
TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4-phenylbutyrate treatment.
Topics: A549 Cells; Butyric Acid; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Caspase 3; Caspase 7; Ce | 2017 |
Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Enzyme Activation; G1 Phase; Humans; JNK Mitogen-Activa | 2004 |