4-phenylbutyric acid has been researched along with Cachexia in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Cachexia: General ill health, malnutrition, and weight loss, usually associated with chronic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Cachexia is a devastating syndrome that causes morbidity and mortality in a large number of patients with cancer." | 1.43 | Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia. ( Bohnert, KR; Gallot, YS; Hindi, SM; Kumar, A; Sato, S; Xiong, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bohnert, KR | 1 |
| Gallot, YS | 1 |
| Sato, S | 1 |
| Xiong, G | 1 |
| Hindi, SM | 1 |
| Kumar, A | 1 |
1 other study available for 4-phenylbutyric acid and Cachexia
| Article | Year |
|---|---|
Inhibition of ER stress and unfolding protein response pathways causes skeletal muscle wasting during cancer cachexia.
Topics: Activating Transcription Factor 6; Adenomatous Polyposis Coli Protein; AMP-Activated Protein Kinases | 2016 |