4-phenylbutyric acid has been researched along with Burns in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Severe burns are typically followed by hypermetabolism characterized by significant muscle wasting, which causes considerable morbidity and mortality." | 1.46 | ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury. ( Chai, J; Chu, W; Li, D; Ma, L; Shen, C; Wang, X, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ma, L | 1 |
| Chu, W | 1 |
| Chai, J | 1 |
| Shen, C | 1 |
| Li, D | 1 |
| Wang, X | 1 |
1 other study available for 4-phenylbutyric acid and Burns
| Article | Year |
|---|---|
ER stress and subsequent activated calpain play a pivotal role in skeletal muscle wasting after severe burn injury.
Topics: Animals; Burns; Calcium; Calpain; Endoplasmic Reticulum Stress; Enzyme Activation; Homeostasis; Male | 2017 |