4-phenylbutyric acid has been researched along with Brugada Syndrome in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Brugada Syndrome: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dolz-Gaitón, P | 1 |
| Núñez, M | 1 |
| Núñez, L | 1 |
| Barana, A | 1 |
| Amorós, I | 1 |
| Matamoros, M | 1 |
| Pérez-Hernández, M | 1 |
| González de la Fuente, M | 1 |
| Alvarez-López, M | 1 |
| Macías-Ruiz, R | 1 |
| Tercedor-Sánchez, L | 1 |
| Jiménez-Jáimez, J | 1 |
| Delpón, E | 1 |
| Caballero, R | 1 |
| Tamargo, J | 1 |
1 other study available for 4-phenylbutyric acid and Brugada Syndrome
| Article | Year |
|---|---|
Functional characterization of a novel frameshift mutation in the C-terminus of the Nav1.5 channel underlying a Brugada syndrome with variable expression in a Spanish family.
Topics: Biological Transport; Brugada Syndrome; Female; Frameshift Mutation; Humans; Mexiletine; Middle Aged | 2013 |