4-phenylbutyric acid has been researched along with Brittle Bone Disease in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Duangchan, T | 1 |
| Tawonsawatruk, T | 1 |
| Angsanuntsukh, C | 1 |
| Trachoo, O | 1 |
| Hongeng, S | 1 |
| Kitiyanant, N | 1 |
| Supokawej, A | 1 |
| Besio, R | 2 |
| Iula, G | 1 |
| Garibaldi, N | 2 |
| Cipolla, L | 2 |
| Sabbioneda, S | 2 |
| Biggiogera, M | 2 |
| Marini, JC | 1 |
| Rossi, A | 2 |
| Forlino, A | 2 |
| Leoni, L | 1 |
| Mottes, M | 1 |
| Aglan, M | 1 |
| Otaify, GA | 1 |
| Temtamy, SA | 1 |
3 other studies available for 4-phenylbutyric acid and Brittle Bone Disease
| Article | Year |
|---|---|
Amelioration of osteogenesis in iPSC-derived mesenchymal stem cells from osteogenesis imperfecta patients by endoplasmic reticulum stress inhibitor.
Topics: Apoptosis; Cells, Cultured; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Human | 2021 |
4-PBA ameliorates cellular homeostasis in fibroblasts from osteogenesis imperfecta patients by enhancing autophagy and stimulating protein secretion.
Topics: Autophagy; Autophagy-Related Protein 5; Cells, Cultured; Collagen Type I; eIF-2 Kinase; Fibroblasts; | 2018 |
Cellular stress due to impairment of collagen prolyl hydroxylation complex is rescued by the chaperone 4-phenylbutyrate.
Topics: Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Collagen; Fibroblasts; Homeostasis; Humans; Hy | 2019 |