4-phenylbutyric acid has been researched along with Breast Cancer in 4 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In chemoresistant breast cancer patients, chemotherapy increased the expression of TM9SF4 proteins in breast tumor samples." | 1.51 | Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells. ( Chan, FL; Chi, K; Hu, X; Leung, LK; Liu, C; Meng, Z; Xie, M; Yao, X; Zhu, Y, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wu, Y | 1 |
| Zhao, Y | 1 |
| He, X | 1 |
| He, Z | 1 |
| Wang, T | 1 |
| Wan, L | 1 |
| Chen, L | 2 |
| Yan, N | 1 |
| Zhu, Y | 1 |
| Xie, M | 1 |
| Meng, Z | 1 |
| Leung, LK | 1 |
| Chan, FL | 1 |
| Hu, X | 1 |
| Chi, K | 1 |
| Liu, C | 1 |
| Yao, X | 1 |
| Chen, W | 1 |
| Wei, F | 1 |
| Xu, J | 1 |
| Wang, Y | 1 |
| Wang, J | 1 |
| Guan, X | 1 |
| Chung, YL | 1 |
| Sheu, ML | 1 |
| Yang, SC | 1 |
| Lin, CH | 1 |
| Yen, SH | 1 |
4 other studies available for 4-phenylbutyric acid and Breast Cancer
| Article | Year |
|---|---|
Hydroxypropyl‑β‑cyclodextrin attenuates the epithelial‑to‑mesenchymal transition via endoplasmic reticulum stress in MDA‑MB‑231 breast cancer cells.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Breast Neoplasms; Cadherins; Cell Line, Tumor; Cell Movement; Cel | 2020 |
Knockdown of TM9SF4 boosts ER stress to trigger cell death of chemoresistant breast cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Dr | 2019 |
Trastuzumab enhances the anti-tumor effects of the histone deacetylase inhibitor sodium butyrate on a HER2-overexpressing breast cancer cell line.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Proto | 2011 |
Resistance to tamoxifen-induced apoptosis is associated with direct interaction between Her2/neu and cell membrane estrogen receptor in breast cancer.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Caspase 3; Caspases; Cell Mem | 2002 |