4-phenylbutyric acid has been researched along with Brain Neoplasms in 9 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In this study we show that the chemical chaperone, glycerol, and the transcriptional regulator, sodium 4-phenylbutyrate, inhibit the constitutively activated inward current and reduce cell growth and migration in glioblastoma multiforme." | 7.73 | Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. ( Benos, DJ; Bubien, JK; Colby, G; Esimai, O; Fuller, CM; Gillespie, GY; Jovov, B; Kovacs, GG; Mapstone, TB; Markert, JM; Pahwa, AK; Vila-Carriles, WH; Zhou, ZH, 2006) |
| "We have investigated in vitro effects of anticancer therapy with the histone deacetylase inhibitor (HDACi) 4-phenylbutyrate (4-PB) combined with receptor tyrosine kinase inhibitors (RTKi) gefitinib or vandetanib on the survival of glioblastoma (U343MGa) and medulloblastoma (D324Med) cells." | 3.77 | Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models. ( Baryawno, N; Ekström, TJ; Johnsen, JI; Larsson, C; Marino, AM; Sofiadis, A; Vukojević, V, 2011) |
| " In this study we show that the chemical chaperone, glycerol, and the transcriptional regulator, sodium 4-phenylbutyrate, inhibit the constitutively activated inward current and reduce cell growth and migration in glioblastoma multiforme." | 3.73 | Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells. ( Benos, DJ; Bubien, JK; Colby, G; Esimai, O; Fuller, CM; Gillespie, GY; Jovov, B; Kovacs, GG; Mapstone, TB; Markert, JM; Pahwa, AK; Vila-Carriles, WH; Zhou, ZH, 2006) |
| " Enthusiasm is lent to this approach by the ability of AN-113 to efficiently kill glioma cells, its bioavailability and potency when administered orally, its capacity to cross the blood-brain barrier, and its effectiveness in combination with radiation." | 1.34 | AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines. ( Entin-Meer, M; Haas-Kogan, DA; Nudelman, A; Rephaeli, A; Yang, X, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Bose, A | 1 |
| Kasle, G | 1 |
| Jana, R | 1 |
| Maulik, M | 1 |
| Thomas, D | 1 |
| Mulchandani, V | 1 |
| Mukherjee, P | 1 |
| Koval, M | 1 |
| Das Sarma, J | 1 |
| Romeo, MA | 1 |
| Gilardini Montani, MS | 1 |
| Benedetti, R | 1 |
| Garufi, A | 1 |
| D'Orazi, G | 1 |
| Cirone, M | 1 |
| Marino, AM | 1 |
| Sofiadis, A | 1 |
| Baryawno, N | 1 |
| Johnsen, JI | 1 |
| Larsson, C | 1 |
| Vukojević, V | 1 |
| Ekström, TJ | 3 |
| Khan, Z | 1 |
| Akhtar, M | 1 |
| Baker, MJ | 1 |
| Brem, S | 1 |
| Daniels, S | 1 |
| Sherman, B | 1 |
| Phuphanich, S | 1 |
| Appelskog, IB | 1 |
| Ammerpohl, O | 1 |
| Svechnikova, IG | 1 |
| Lui, WO | 1 |
| Almqvist, PM | 1 |
| Vila-Carriles, WH | 1 |
| Kovacs, GG | 1 |
| Jovov, B | 1 |
| Zhou, ZH | 1 |
| Pahwa, AK | 1 |
| Colby, G | 1 |
| Esimai, O | 1 |
| Gillespie, GY | 1 |
| Mapstone, TB | 1 |
| Markert, JM | 1 |
| Fuller, CM | 1 |
| Bubien, JK | 1 |
| Benos, DJ | 1 |
| Entin-Meer, M | 1 |
| Rephaeli, A | 1 |
| Yang, X | 1 |
| Nudelman, A | 2 |
| Haas-Kogan, DA | 1 |
| Smigel, K | 1 |
9 other studies available for 4-phenylbutyric acid and Brain Neoplasms
| Article | Year |
|---|---|
Regulatory role of endoplasmic reticulum resident chaperone protein ERp29 in anti-murine β-coronavirus host cell response.
Topics: Animals; Astrocytoma; Brain Neoplasms; Cell Communication; Cell Line, Tumor; Connexin 43; Disease Su | 2023 |
PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR.
Topics: Brain Neoplasms; Butyric Acid; Cell Line, Tumor; Cell Survival; Down-Regulation; Glioblastoma; Human | 2020 |
Enhanced effects by 4-phenylbutyrate in combination with RTK inhibitors on proliferation in brain tumor cell models.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line, Tumor; Cell Proliferatio | 2011 |
HDAC inhibitor 4-phenylbutyrate preserves immature phenotype of human embryonic midbrain stem cells: implications for the involvement of DNA methyltransferase.
Topics: Biomarkers; Brain Neoplasms; Cell Differentiation; Cell Line; Cell Proliferation; DNA (Cytosine-5-)- | 2011 |
Complete response of a recurrent, multicentric malignant glioma in a patient treated with phenylbutyrate.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Femal | 2002 |
Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Down-Regulation; Enzyme I | 2004 |
Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells.
Topics: Acid Sensing Ion Channels; Amiloride; Antineoplastic Agents; Brain Neoplasms; Cell Membrane; Cell Mo | 2006 |
AN-113, a novel prodrug of 4-phenylbutyrate with increased anti-neoplastic activity in glioma cell lines.
Topics: Antineoplastic Agents; Astrocytes; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Prol | 2007 |
Non-toxic drug being tested to treat cancer and anemias.
Topics: Anemia; Brain Neoplasms; Glutamine; Humans; Male; Phenylacetates; Phenylbutyrates; Prostatic Neoplas | 1992 |