4-phenylbutyric acid has been researched along with Brain Ischemia in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tung, WF | 1 |
| Chen, WJ | 1 |
| Hung, HC | 1 |
| Liu, GY | 1 |
| Tung, JN | 1 |
| Huang, CC | 1 |
| Lin, CL | 1 |
| Qi, X | 1 |
| Hosoi, T | 1 |
| Okuma, Y | 1 |
| Kaneko, M | 1 |
| Nomura, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for 4-phenylbutyric acid and Brain Ischemia
| Article | Year |
|---|---|
4-Phenylbutyric Acid (4-PBA) and Lithium Cooperatively Attenuate Cell Death during Oxygen-Glucose Deprivation (OGD) and Reoxygenation.
Topics: Brain Ischemia; Cell Death; Cells, Cultured; Drug Synergism; Endoplasmic Reticulum Stress; Glucose; | 2015 |
Sodium 4-phenylbutyrate protects against cerebral ischemic injury.
Topics: Animals; Apoptosis; Brain Ischemia; Disease Models, Animal; Endoplasmic Reticulum; Male; Mice; Mice, | 2004 |