4-phenylbutyric acid has been researched along with Brain Diseases, Metabolic, Familial in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Salazar, MD | 1 |
| Zelt, NB | 1 |
| Saldivar, R | 1 |
| Kuntz, CP | 1 |
| Chen, S | 1 |
| Penn, WD | 1 |
| Bonneau, R | 1 |
| Koehler Leman, J | 1 |
| Schlebach, JP | 1 |
| Giva, S | 1 |
| Finnegan, J | 1 |
| Ihidero, P | 1 |
| Maguire, G | 1 |
| Power, B | 1 |
| Knerr, I | 1 |
| Monavari, A | 1 |
| El-Kasaby, A | 1 |
| Kasture, A | 1 |
| Koban, F | 1 |
| Hotka, M | 1 |
| Asjad, HMM | 1 |
| Kubista, H | 1 |
| Freissmuth, M | 1 |
| Sucic, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for 4-phenylbutyric acid and Brain Diseases, Metabolic, Familial
| Article | Year |
|---|---|
Classification of the Molecular Defects Associated with Pathogenic Variants of the
Topics: Brain Diseases, Metabolic, Inborn; Creatine; HEK293 Cells; Humans; Membrane Transport Proteins; Ment | 2020 |
Hyperammonaemia in Neonates and Young Children: Potential Metabolic Causes, Diagnostic Approaches and Clinical Consequences
Topics: Ammonia; Arginine; Biomarkers; Brain Diseases, Metabolic, Inborn; Carnitine; Critical Illness; Diet, | 2019 |
Rescue by 4-phenylbutyrate of several misfolded creatine transporter-1 variants linked to the creatine transporter deficiency syndrome.
Topics: Animals; Brain Diseases, Metabolic, Inborn; Calnexin; Cell Membrane; Creatine; Endoplasmic Reticulum | 2019 |