4-phenylbutyric acid has been researched along with Bone Loss, Osteoclastic in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Park, HJ | 1 |
| Son, HJ | 1 |
| Sul, OJ | 1 |
| Suh, JH | 1 |
| Choi, HS | 1 |
| Li, H | 1 |
| Li, D | 1 |
| Ma, Z | 1 |
| Qian, Z | 1 |
| Kang, X | 1 |
| Jin, X | 1 |
| Li, F | 1 |
| Wang, X | 1 |
| Chen, Q | 1 |
| Sun, H | 1 |
| Wu, S | 1 |
2 other studies available for 4-phenylbutyric acid and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts.
Topics: Animals; Autophagy; Bone Density; Bone Resorption; Cancellous Bone; Cell Survival; Dose-Response Rel | 2018 |
Defective autophagy in osteoblasts induces endoplasmic reticulum stress and causes remarkable bone loss.
Topics: Animals; Apoptosis; Autophagy; Autophagy-Related Protein 7; Biomarkers; Bone and Bones; Bone Resorpt | 2018 |