4-phenylbutyric acid has been researched along with Blood Pressure, High in 8 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Proteinuria is one of the primary risk factors for the progression of chronic kidney disease (CKD) and has been implicated in the induction of endoplasmic reticulum (ER) stress." | 1.46 | Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat. ( Ask, K; Brimble, E; Carlisle, RE; Chahal, J; Dickhout, JG; Lu, C; Upagupta, C; Yum, V, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spitler, KM | 1 |
| Matsumoto, T | 1 |
| Webb, RC | 1 |
| Takayanagi, T | 1 |
| Kawai, T | 1 |
| Forrester, SJ | 1 |
| Obama, T | 1 |
| Tsuji, T | 1 |
| Fukuda, Y | 1 |
| Elliott, KJ | 1 |
| Tilley, DG | 1 |
| Davisson, RL | 1 |
| Park, JY | 1 |
| Eguchi, S | 1 |
| Carlisle, RE | 3 |
| Werner, KE | 1 |
| Yum, V | 2 |
| Lu, C | 3 |
| Tat, V | 1 |
| Memon, M | 1 |
| No, Y | 1 |
| Ask, K | 3 |
| Dickhout, JG | 3 |
| Brimble, E | 1 |
| Chahal, J | 1 |
| Upagupta, C | 1 |
| Mohammed-Ali, Z | 1 |
| Marway, MK | 1 |
| Lukic, D | 1 |
| Krepinsky, JC | 1 |
| Nagamani, SC | 1 |
| Erez, A | 1 |
| Lee, B | 1 |
| Park, CS | 1 |
| Cha, H | 1 |
| Kwon, EJ | 1 |
| Sreenivasaiah, PK | 1 |
| Kim, DH | 1 |
| Liang, B | 1 |
| Wang, S | 1 |
| Wang, Q | 1 |
| Zhang, W | 1 |
| Viollet, B | 1 |
| Zhu, Y | 1 |
| Zou, MH | 1 |
1 review available for 4-phenylbutyric acid and Blood Pressure, High
| Article | Year |
|---|---|
Argininosuccinate lyase deficiency.
Topics: Arginine; Argininosuccinate Lyase; Argininosuccinic Acid; Argininosuccinic Aciduria; Child, Preschoo | 2012 |
7 other studies available for 4-phenylbutyric acid and Blood Pressure, High
| Article | Year |
|---|---|
Suppression of endoplasmic reticulum stress improves endothelium-dependent contractile responses in aorta of the spontaneously hypertensive rat.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Arachidonic Acid; bcl-2-Associated X Protein | 2013 |
Role of epidermal growth factor receptor and endoplasmic reticulum stress in vascular remodeling induced by angiotensin II.
Topics: ADAM Proteins; ADAM17 Protein; Angiotensin II; Animals; Disease Models, Animal; Endoplasmic Reticulu | 2015 |
Endoplasmic reticulum stress inhibition reduces hypertension through the preservation of resistance blood vessel structure and function.
Topics: Animals; Blood Pressure; Endoplasmic Reticulum Stress; Hypertension; Male; Mesenteric Arteries; Musc | 2016 |
Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat.
Topics: Animals; Blood Pressure; Disease Models, Animal; Disease Progression; Endoplasmic Reticulum Stress; | 2017 |
Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.
Topics: Angiotensin II; Animals; Apoptosis; Biopsy; Blood Pressure; Disease Models, Animal; Endoplasmic Reti | 2017 |
The chemical chaperone 4-phenylbutyric acid attenuates pressure-overload cardiac hypertrophy by alleviating endoplasmic reticulum stress.
Topics: Administration, Oral; Animals; Aorta; Apoptosis; Atrial Natriuretic Factor; Biomarkers; Cardiomegaly | 2012 |
Aberrant endoplasmic reticulum stress in vascular smooth muscle increases vascular contractility and blood pressure in mice deficient of AMP-activated protein kinase-α2 in vivo.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Animals; Antihypertensive | 2013 |