4-phenylbutyric acid has been researched along with Bladder Cancer in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Finally, we showed that treatment of bladder cancer cells with the methylation inhibitor, 5-aza-2'-deoxycytidine, alone or in combination with the histone deacetylase inhibitors MS-275 and 4-phenylbutyrate could strongly induce the expression of MAGE-A9." | 1.34 | MAGE-A9 mRNA and protein expression in bladder cancer. ( Bergeron, A; Fradet, Y; Larue, H; Picard, V, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Saito, Y | 1 |
| Friedman, JM | 1 |
| Chihara, Y | 1 |
| Egger, G | 1 |
| Chuang, JC | 1 |
| Liang, G | 1 |
| Picard, V | 1 |
| Bergeron, A | 1 |
| Larue, H | 1 |
| Fradet, Y | 1 |
2 other studies available for 4-phenylbutyric acid and Bladder Cancer
| Article | Year |
|---|---|
Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells.
Topics: Antineoplastic Agents; Azacitidine; Calcium-Binding Proteins; Cell Line, Tumor; Decitabine; EGF Fami | 2009 |
MAGE-A9 mRNA and protein expression in bladder cancer.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Azacitidine; Benzamides; Cell Line, Tumor; Decitabine; G | 2007 |