4-phenylbutyric acid has been researched along with Autoimmune Diabetes in 7 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pancreatic beta cell destruction in type 1 diabetes may be mediated by cytokines such as IL-1β, IFN-γ and TNF-α." | 1.38 | Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets. ( Biden, TJ; Chan, JY; Laybutt, DR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, D | 1 |
| Zhou, Q | 3 |
| Wang, Y | 1 |
| Xu, J | 3 |
| Guo, W | 1 |
| Jia, Y | 1 |
| Wang, D | 1 |
| Chi, B | 1 |
| Lombardi, A | 1 |
| Tomer, Y | 1 |
| Xu, TY | 1 |
| Chen, RH | 1 |
| Wang, P | 1 |
| Zhang, RY | 1 |
| Ke, SF | 1 |
| Miao, CY | 1 |
| Chan, JY | 1 |
| Biden, TJ | 1 |
| Laybutt, DR | 1 |
| Fu, SH | 1 |
| Chen, ST | 1 |
| Hsu, BR | 1 |
7 other studies available for 4-phenylbutyric acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endopla | 2023 |
Effect of 4-Phenylbutyric Acid and Tauroursodeoxycholic Acid on Magnesium and Calcium Metabolism in Streptozocin-Induced Type 1 Diabetic Mice.
Topics: Animals; Calcium; Diabetes Mellitus, Type 1; Heart; Kidney; Liver; Magnesium; Male; Mice; Myocardium | 2019 |
Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model.
Topics: Animals; Copper; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Liver; Mice; Phenylbuty | 2016 |
Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress.
Topics: Apoptosis; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 1; Endoplasmic Reticulum Stress; Huma | 2017 |
4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
Cross-talk between the unfolded protein response and nuclear factor-κB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets.
Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Survival; Cytokines; Diabetes Mel | 2012 |
Attenuation of primary nonfunction for syngeneic islet graft using sodium 4-phenylbutyrate.
Topics: Animals; Diabetes Mellitus, Type 1; Hyperglycemia; Islets of Langerhans Transplantation; Mice; Mice, | 2005 |