4-phenylbutyric acid has been researched along with Atherosclerosis in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Atherosclerosis: A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atherosclerosis is thought to be associated with endoplasmic reticulum (ER) dysfunction and the accumulation of unfolded proteins." | 1.35 | Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters. ( Hideshima, M; Ishii, Y; Kurokawa, M; Kyuwa, S; Yoshikawa, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Espada, S | 1 |
| Stavik, B | 1 |
| Holm, S | 1 |
| Sagen, EL | 1 |
| Bjerkeli, V | 1 |
| Skjelland, M | 1 |
| Dahl, TB | 1 |
| Espevik, T | 1 |
| Kanse, S | 1 |
| Sandset, PM | 1 |
| Skretting, G | 1 |
| Halvorsen, B | 1 |
| He, B | 1 |
| Moreau, R | 1 |
| Mohammadi, A | 1 |
| Najar, AG | 1 |
| Yaghoobi, MM | 1 |
| Jahani, Y | 1 |
| Vahabzadeh, Z | 1 |
| Kurokawa, M | 1 |
| Hideshima, M | 1 |
| Ishii, Y | 1 |
| Kyuwa, S | 1 |
| Yoshikawa, Y | 1 |
| KRITCHEVSKY, D | 1 |
| MOYER, AW | 1 |
| TESAR, WC | 1 |
| MCCANDLESS, RF | 1 |
| LOGAN, JB | 1 |
| BROWN, RA | 1 |
| ENGLERT, M | 1 |
1 review available for 4-phenylbutyric acid and Atherosclerosis
| Article | Year |
|---|---|
Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
Topics: Adipogenesis; Animals; Atherosclerosis; Butyric Acid; Histone Deacetylase Inhibitors; Humans; Lipid | 2019 |
4 other studies available for 4-phenylbutyric acid and Atherosclerosis
| Article | Year |
|---|---|
Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages.
Topics: Atherosclerosis; Carotid Arteries; Cholesterol; Crystallization; Endarterectomy, Carotid; Endoplasmi | 2017 |
Trimethylamine-N-Oxide Treatment Induces Changes in the ATP-Binding Cassette Transporter A1 and Scavenger Receptor A1 in Murine Macrophage J774A.1 cells.
Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter 1; Cell Line; Endoplasmic Reticulum Stres | 2016 |
Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters.
Topics: Animals; Antineoplastic Agents; Aorta, Abdominal; Atherosclerosis; Calreticulin; Cricetinae; Diabete | 2009 |
The effect of sodium 2-phenylbutyrate in experimental atherosclerosis.
Topics: Arteriosclerosis; Atherosclerosis; Butyrates; Phenylbutyrates; Sodium | 1956 |