4-phenylbutyric acid has been researched along with Aneuploid in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our study reveals aneuploidy-associated stress as a potential therapeutic target for human trisomies, including Down syndrome." | 1.51 | Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts. ( Arahori, H; Banno, K; Hirata, K; Kawatani, K; Kitabatake, Y; Kokubu, C; Nakanishi, M; Nambara, T; Nawa, N; Nishimura, K; Ohtaka, M; Okuzaki, D; Omori, S; Ozono, K; Takeda, J; Taniguchi, H; Wada, K, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nawa, N | 1 |
| Hirata, K | 1 |
| Kawatani, K | 1 |
| Nambara, T | 1 |
| Omori, S | 1 |
| Banno, K | 1 |
| Kokubu, C | 1 |
| Takeda, J | 1 |
| Nishimura, K | 1 |
| Ohtaka, M | 1 |
| Nakanishi, M | 1 |
| Okuzaki, D | 1 |
| Taniguchi, H | 1 |
| Arahori, H | 1 |
| Wada, K | 1 |
| Kitabatake, Y | 1 |
| Ozono, K | 1 |
1 other study available for 4-phenylbutyric acid and Aneuploid
| Article | Year |
|---|---|
Elimination of protein aggregates prevents premature senescence in human trisomy 21 fibroblasts.
Topics: Aneuploidy; Cell Proliferation; Cellular Senescence; Energy Metabolism; Fibroblasts; Glucose; Humans | 2019 |