4-phenylbutyric acid has been researched along with Amyloid Deposits in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ricobaraza, A | 1 |
| Cuadrado-Tejedor, M | 1 |
| Marco, S | 1 |
| Pérez-Otaño, I | 1 |
| García-Osta, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pharmacokinetic and Pharmacodynamic Study of AMX0035 in Patients With ALS[NCT04987671] | Phase 1/Phase 2 | 14 participants (Anticipated) | Interventional | 2021-08-05 | Active, not recruiting | ||
| Phenylbutyrate for Monogenetic Developmental and Epileptic Encephalopathy[NCT04937062] | Early Phase 1 | 50 participants (Anticipated) | Interventional | 2021-03-01 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for 4-phenylbutyric acid and Amyloid Deposits
| Article | Year |
|---|---|
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Dendritic S | 2012 |