4-phenylbutyric acid has been researched along with Alloxan Diabetes in 18 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of 4-PBA treatment was gavaged at a dose of 1 g/kg body weight each day for 12 weeks." | 1.37 | Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. ( Feng, B; Guo, YH; Liu, L; Luo, ZF; Mu, J; Pang, Q; Qi, W; Ye, ZL; Yuan, FH; Zeng, W, 2011) |
| "Atherosclerosis is thought to be associated with endoplasmic reticulum (ER) dysfunction and the accumulation of unfolded proteins." | 1.35 | Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters. ( Hideshima, M; Ishii, Y; Kurokawa, M; Kyuwa, S; Yoshikawa, Y, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 12 (66.67) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Xing, D | 1 |
| Zhou, Q | 3 |
| Wang, Y | 1 |
| Xu, J | 2 |
| Abdel-Ghaffar, A | 2 |
| Elhossary, GG | 1 |
| Mahmoud, AM | 1 |
| Elshazly, AHM | 1 |
| Hassanin, OA | 1 |
| Saleh, A | 1 |
| Mansour, SM | 1 |
| Metwally, FG | 1 |
| Hanafy, LK | 2 |
| Karam, SH | 1 |
| Darweesh, N | 1 |
| Ata, AM | 1 |
| de Pablo, S | 1 |
| Rodríguez-Comas, J | 1 |
| Díaz-Catalán, D | 1 |
| Alcarraz-Vizán, G | 1 |
| Castaño, C | 1 |
| Moreno-Vedia, J | 1 |
| Montane, J | 1 |
| Parrizas, M | 1 |
| Servitja, JM | 1 |
| Novials, A | 1 |
| Kong, FJ | 1 |
| Ma, LL | 1 |
| Guo, JJ | 1 |
| Xu, LH | 1 |
| Li, Y | 1 |
| Qu, S | 1 |
| Shruthi, K | 2 |
| Reddy, SS | 2 |
| Chitra, PS | 1 |
| Reddy, GB | 2 |
| Joy, D | 1 |
| Gadallah, SH | 1 |
| Ghanem, HM | 1 |
| Metwaly, FG | 1 |
| Ahmed, EK | 1 |
| Zhu, M | 1 |
| Guo, M | 1 |
| Fei, L | 1 |
| Pan, XQ | 1 |
| Liu, QQ | 1 |
| Bhatta, M | 1 |
| Ma, JH | 1 |
| Wang, JJ | 1 |
| Sakowski, J | 1 |
| Zhang, SX | 1 |
| Inceoglu, B | 1 |
| Bettaieb, A | 1 |
| Trindade da Silva, CA | 1 |
| Lee, KS | 1 |
| Haj, FG | 1 |
| Hammock, BD | 1 |
| Wang, D | 1 |
| Chi, B | 1 |
| Gu, H | 1 |
| Yu, J | 1 |
| Dong, D | 1 |
| Wang, JY | 1 |
| Fang, S | 1 |
| Yang, P | 2 |
| Kurokawa, M | 1 |
| Hideshima, M | 1 |
| Ishii, Y | 1 |
| Kyuwa, S | 1 |
| Yoshikawa, Y | 1 |
| Xu, TY | 1 |
| Chen, RH | 1 |
| Wang, P | 1 |
| Zhang, RY | 1 |
| Ke, SF | 1 |
| Miao, CY | 1 |
| Luo, ZF | 2 |
| Feng, B | 2 |
| Mu, J | 2 |
| Qi, W | 2 |
| Zeng, W | 2 |
| Guo, YH | 2 |
| Pang, Q | 2 |
| Ye, ZL | 2 |
| Liu, L | 2 |
| Yuan, FH | 2 |
| Li, X | 1 |
| Xu, C | 1 |
| Hsu, BR | 1 |
| Chen, ST | 1 |
| Fu, SH | 1 |
18 other studies available for 4-phenylbutyric acid and Alloxan Diabetes
| Article | Year |
|---|---|
Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Models, Animal; Endopla | 2023 |
Effects of 4-phenylbutyric acid on the development of diabetic retinopathy in diabetic rats: regulation of endoplasmic reticulum stress-oxidative activation.
Topics: Animals; Apoptosis; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Endoplasmic Reticulum Str | 2023 |
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity.
Topics: Amyloid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal | 2021 |
Endoplasmic reticulum stress/autophagy pathway is involved in diabetes-induced neuronal apoptosis and cognitive decline in mice.
Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Cognitive Dysfunction; Diabetes Mellitus, Experiment | 2018 |
Ubiquitin-proteasome system and ER stress in the brain of diabetic rats.
Topics: Animals; Apoptosis; Brain; Cell Death; Cerebral Cortex; Diabetes Mellitus, Experimental; Endoplasmic | 2019 |
4-PBA prevents diabetic muscle atrophy in rats by modulating ER stress response and ubiquitin-proteasome system.
Topics: Animals; Apoptosis; Biomarkers; Diabetes Mellitus, Experimental; Endoplasmic Reticulum Stress; Injec | 2019 |
4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Endo | 2021 |
4-phenylbutyric acid attenuates endoplasmic reticulum stress-mediated pancreatic β-cell apoptosis in rats with streptozotocin-induced diabetes.
Topics: Animals; Apoptosis; Cytoprotection; Diabetes Mellitus, Experimental; Down-Regulation; Endoplasmic Re | 2014 |
Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Bone Marrow Cells; Cell Movement; Cell Separation; Diabetes Melli | 2015 |
Endoplasmic reticulum stress in the peripheral nervous system is a significant driver of neuropathic pain.
Topics: Animals; Apoptosis; Autophagy; Blood Glucose; Blotting, Western; Diabetes Mellitus, Experimental; Di | 2015 |
Effect of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Metabolism of Copper and Zinc in Type 1 Diabetic Mice Model.
Topics: Animals; Copper; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Liver; Mice; Phenylbuty | 2016 |
High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress.
Topics: 3' Untranslated Regions; Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Embryo, | 2016 |
Aortic ER stress in streptozotocin-induced diabetes mellitus in APA hamsters.
Topics: Animals; Antineoplastic Agents; Aorta, Abdominal; Atherosclerosis; Calreticulin; Cricetinae; Diabete | 2009 |
4-Phenyl butyric acid does not generally reduce glucose levels in rodent models of diabetes.
Topics: Animals; Blood Glucose; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation.
Topics: Animals; Antioxidants; Blood Urea Nitrogen; Creatinine; Diabetes Mellitus, Experimental; Diabetic Ne | 2010 |
Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response.
Topics: Animals; Chemokine CCL2; Cytokines; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endopla | 2011 |
c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy.
Topics: Animals; Apoptosis; Biomarkers; Caspase 3; Caspase 8; Diabetes Mellitus, Experimental; Endoplasmic R | 2013 |
Enhancing engraftment of islets using perioperative sodium 4-phenylbutyrate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Diabetes Mellitus, Exp | 2006 |