4-phenylbutyric acid has been researched along with Aging in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Q | 1 |
| Samidurai, A | 1 |
| Thompson, J | 1 |
| Hu, Y | 1 |
| Das, A | 1 |
| Willard, B | 1 |
| Lesnefsky, EJ | 1 |
| Hayashi, G | 1 |
| Labelle-Dumais, C | 1 |
| Gould, DB | 1 |
| Li, H | 1 |
| Wen, W | 1 |
| Xu, H | 1 |
| Wu, H | 1 |
| Xu, M | 1 |
| Frank, JA | 1 |
| Luo, J | 1 |
| Brown, MK | 1 |
| Chan, MT | 1 |
| Zimmerman, JE | 1 |
| Pack, AI | 1 |
| Jackson, NE | 1 |
| Naidoo, N | 1 |
| Sturm, E | 1 |
| Fellner, L | 1 |
| Krismer, F | 1 |
| Poewe, W | 1 |
| Wenning, GK | 1 |
| Stefanova, N | 1 |
5 other studies available for 4-phenylbutyric acid and Aging
| Article | Year |
|---|---|
Endoplasmic reticulum stress-mediated mitochondrial dysfunction in aged hearts.
Topics: Aging; Animals; Electron Transport Complex I; Endoplasmic Reticulum Stress; Hydrogen Peroxide; Male; | 2020 |
Use of sodium 4-phenylbutyrate to define therapeutic parameters for reducing intracerebral hemorrhage and myopathy in
Topics: Aging; Animals; Animals, Newborn; Cerebral Hemorrhage; Collagen Type IV; Female; Male; Mice, Inbred | 2018 |
4-Phenylbutyric Acid Protects Against Ethanol-Induced Damage in the Developing Mouse Brain.
Topics: Activating Transcription Factor 6; Aging; Animals; Apoptosis; Astrocytes; Biomarkers; Caspase 12; Ce | 2019 |
Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.
Topics: Aging; Animals; Behavior, Animal; DNA-Binding Proteins; Drosophila melanogaster; Endoplasmic Reticul | 2014 |
Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.
Topics: Aging; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Epigenesis, Genetic; Female; Gait Di | 2016 |