4-phenylbutyric acid has been researched along with Adenocarcinoma in 3 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Adenocarcinoma: A malignant epithelial tumor with a glandular organization.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paraquat (PQ) is a widely used herbicide in the world despite being highly toxic to humans." | 1.48 | Paraquat toxicity is attenuated by 4-phenylbutyrate-induced phosphorylation of ERK2 via PI3K in A549 cells. ( Asari, M; Doi, H; Horioka, K; Hoshina, C; Isozaki, S; Matsubara, K; Okuda, K; Omura, T; Shimizu, K; Shiono, H; Tanaka, H; Yamada, H, 2018) |
| "Inhibition of NF-κB in prostate cancer cells undergoing Tg-mediated ER stress by BAY 11-7082 abrogates Lcn2 upregulation." | 1.37 | ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner. ( Almanza, G; Mahadevan, NR; Pérez, AF; Rodvold, J; Wheeler, MC; Zanetti, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoshina, C | 1 |
| Omura, T | 1 |
| Okuda, K | 1 |
| Tanaka, H | 1 |
| Asari, M | 1 |
| Isozaki, S | 1 |
| Horioka, K | 1 |
| Yamada, H | 1 |
| Doi, H | 1 |
| Shiono, H | 1 |
| Matsubara, K | 1 |
| Shimizu, K | 1 |
| Mahadevan, NR | 1 |
| Rodvold, J | 1 |
| Almanza, G | 1 |
| Pérez, AF | 1 |
| Wheeler, MC | 1 |
| Zanetti, M | 1 |
| Zhang, X | 1 |
| Wei, L | 1 |
| Yang, Y | 1 |
| Yu, Q | 1 |
3 other studies available for 4-phenylbutyric acid and Adenocarcinoma
| Article | Year |
|---|---|
Paraquat toxicity is attenuated by 4-phenylbutyrate-induced phosphorylation of ERK2 via PI3K in A549 cells.
Topics: A549 Cells; Adenocarcinoma; Cell Survival; Cytoprotection; Herbicides; Humans; Lung Neoplasms; Mitog | 2018 |
ER stress drives Lipocalin 2 upregulation in prostate cancer cells in an NF-κB-dependent manner.
Topics: Acute-Phase Proteins; Adenocarcinoma; Animals; Cell Line, Tumor; Endoplasmic Reticulum; Gene Express | 2011 |
Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway.
Topics: Adenocarcinoma; Apoptosis; Cell Line, Tumor; Enzyme Activation; G1 Phase; Humans; JNK Mitogen-Activa | 2004 |