4-phenylbutyric acid has been researched along with Addison Disease and Cerebral Sclerosis in 9 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Nemeth, CL | 1 |
| Gӧk, Ö | 1 |
| Tomlinson, SN | 1 |
| Sharma, A | 1 |
| Moser, AB | 2 |
| Kannan, S | 1 |
| Kannan, RM | 1 |
| Fatemi, A | 1 |
| Jang, J | 1 |
| Kang, HC | 1 |
| Kim, HS | 1 |
| Kim, JY | 1 |
| Huh, YJ | 1 |
| Kim, DS | 1 |
| Yoo, JE | 1 |
| Lee, JA | 1 |
| Lim, B | 1 |
| Lee, J | 1 |
| Yoon, TM | 1 |
| Park, IH | 1 |
| Hwang, DY | 1 |
| Daley, GQ | 1 |
| Kim, DW | 1 |
| Brose, RD | 1 |
| Shin, G | 1 |
| McGuinness, MC | 2 |
| Schneidereith, T | 1 |
| Purvis, S | 1 |
| Dong, GX | 1 |
| Keefer, J | 1 |
| Spencer, F | 1 |
| Smith, KD | 2 |
| Imamura, A | 1 |
| Suzuki, Y | 1 |
| Gondcaille, C | 1 |
| Depreter, M | 1 |
| Fourcade, S | 1 |
| Lecca, MR | 1 |
| Leclercq, S | 1 |
| Martin, PG | 1 |
| Pineau, T | 1 |
| Cadepond, F | 1 |
| ElEtr, M | 1 |
| Bertrand, N | 1 |
| Beley, A | 1 |
| Duclos, S | 1 |
| De Craemer, D | 1 |
| Roels, F | 1 |
| Savary, S | 1 |
| Bugaut, M | 1 |
| Kemp, S | 2 |
| Wanders, RJ | 2 |
| Wei, HM | 1 |
| Lu, JF | 1 |
| Braiterman, LT | 1 |
| Watkins, PA | 1 |
| Girard, S | 1 |
| Bruckert, E | 1 |
| Turpin, G | 1 |
3 reviews available for 4-phenylbutyric acid and Addison Disease and Cerebral Sclerosis
| Article | Year |
|---|---|
[X-linked adrenoleukodystrophy (ALD)].
Topics: Adrenoleukodystrophy; Age of Onset; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Bin | 2004 |
X-linked adrenoleukodystrophy: very long-chain fatty acid metabolism, ABC half-transporters and the complicated route to treatment.
Topics: Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cassette T | 2007 |
[Endocrine disease in adrenoleukodystrophy].
Topics: Adrenal Insufficiency; Adrenoleukodystrophy; Adult; Anticholesteremic Agents; Bone Marrow Transplant | 2001 |
6 other studies available for 4-phenylbutyric acid and Addison Disease and Cerebral Sclerosis
| Article | Year |
|---|---|
Targeted Brain Delivery of Dendrimer-4-Phenylbutyrate Ameliorates Neurological Deficits in a Long-Term ABCD1-Deficient Mouse Model of X-Linked Adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D, Member 1; ATP-Binding | 2023 |
Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.
Topics: Adrenoleukodystrophy; ATP Binding Cassette Transporter, Subfamily D; ATP-Binding Cassette Transporte | 2011 |
Activation of the stress proteome as a mechanism for small molecule therapeutics.
Topics: Adrenoleukodystrophy; Cell Line; Drug Therapy; Humans; Hydroxamic Acids; Hydroxyurea; Isothiocyanate | 2012 |
Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator.
Topics: Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cassette T | 2005 |
A happier sequel to Lorenzo's Oil?
Topics: Adrenoleukodystrophy; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cassette Transporte | 1998 |
Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy.
Topics: Adrenoleukodystrophy; Animals; ATP Binding Cassette Transporter, Subfamily D; ATP Binding Cassette T | 1998 |