4-phenylbutyric acid has been researched along with Acute Hepatic Failure in 2 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, F | 2 |
| Zhou, L | 2 |
| Zhang, X | 2 |
| Wen, T | 1 |
| Shi, H | 2 |
| Xie, B | 1 |
| Li, Z | 1 |
| Chen, D | 2 |
| Wang, Z | 1 |
| Duan, Z | 2 |
| Zhang, L | 1 |
| Wang, X | 1 |
| Zheng, S | 1 |
| Chen, Y | 1 |
| Li, L | 1 |
| Zhao, C | 1 |
2 other studies available for 4-phenylbutyric acid and Acute Hepatic Failure
| Article | Year |
|---|---|
Endoplasmic reticulum stress-activated glycogen synthase kinase 3β aggravates liver inflammation and hepatotoxicity in mice with acute liver failure.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Apoptosis; Aspartate Aminotransferases; End | 2015 |
Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure.
Topics: Animals; Apoptosis; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stre | 2016 |