4-phenylbutyric acid has been researched along with Acute Disease in 5 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study aimed to determine whether intestinal epithelial cell (IECs) apoptosis could be induced by endoplasmic reticulum stress (ERS) in severe acute pancreatitis (SAP), and the role of chemical chaperone 4-phenylbutyric acid (4-PBA) in SAP-associated intestinal barrier injury." | 7.91 | 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis. ( Deng, WH; Guo, WY; Hong, YP; Mei, FC; Wang, WX; Xu, S; You, YD; Yu, J; Zhao, L; Zhou, Y, 2019) |
| "The present study aimed to determine whether intestinal epithelial cell (IECs) apoptosis could be induced by endoplasmic reticulum stress (ERS) in severe acute pancreatitis (SAP), and the role of chemical chaperone 4-phenylbutyric acid (4-PBA) in SAP-associated intestinal barrier injury." | 3.91 | 4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis. ( Deng, WH; Guo, WY; Hong, YP; Mei, FC; Wang, WX; Xu, S; You, YD; Yu, J; Zhao, L; Zhou, Y, 2019) |
| "Successful treatment of acute promyelocytic leukemia (APL) has identified several novel approaches to induce leukemic cell differentiation and selective apoptosis by overcoming the site-specific transcriptional repression by dominant fusion leukemogenic proteins characteristic of APL and other forms of acute myelogenous leukemia (AML)." | 2.41 | Differentiation therapy in acute myelogenous leukemia (non-APL). ( Waxman, S, 2000) |
| "Experimental allergic encephalomyelitis (EAE) is the animal model for multiple sclerosis." | 1.32 | Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps. ( Banik, NL; Dasgupta, S; Jana, M; Pahan, K; Zhou, Y, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| You, YD | 1 |
| Deng, WH | 1 |
| Guo, WY | 1 |
| Zhao, L | 1 |
| Mei, FC | 1 |
| Hong, YP | 1 |
| Zhou, Y | 2 |
| Yu, J | 1 |
| Xu, S | 1 |
| Wang, WX | 1 |
| Dasgupta, S | 1 |
| Jana, M | 1 |
| Banik, NL | 1 |
| Pahan, K | 1 |
| Maslak, P | 1 |
| Chanel, S | 1 |
| Camacho, LH | 1 |
| Soignet, S | 1 |
| Pandolfi, PP | 1 |
| Guernah, I | 1 |
| Warrell, R | 1 |
| Nimer, S | 1 |
| Ryningen, A | 1 |
| Stapnes, C | 1 |
| Bruserud, Ø | 1 |
| Waxman, S | 1 |
1 review available for 4-phenylbutyric acid and Acute Disease
| Article | Year |
|---|---|
Differentiation therapy in acute myelogenous leukemia (non-APL).
Topics: Acute Disease; Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; Butyrates; Cell Differentiati | 2000 |
1 trial available for 4-phenylbutyric acid and Acute Disease
| Article | Year |
|---|---|
Pilot study of combination transcriptional modulation therapy with sodium phenylbutyrate and 5-azacytidine in patients with acute myeloid leukemia or myelodysplastic syndrome.
Topics: Acetylation; Acute Disease; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Aza | 2006 |
3 other studies available for 4-phenylbutyric acid and Acute Disease
| Article | Year |
|---|---|
4-Phenylbutyric Acid Attenuates Endoplasmic Reticulum Stress-Mediated Intestinal Epithelial Cell Apoptosis in Rats with Severe Acute Pancreatitis.
Topics: Acute Disease; Animals; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Endoplasmi | 2019 |
Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps.
Topics: Acute Disease; Administration, Oral; Adoptive Transfer; Animals; Anti-Inflammatory Agents, Non-Stero | 2003 |
Clonogenic acute myelogenous leukemia cells are heterogeneous with regard to regulation of differentiation and effect of epigenetic pharmacological targeting.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Azacitidine; Cell C | 2007 |