4-phenylbutyric acid has been researched along with ARG1 Deficiency in 1 studies
4-phenylbutyric acid: RN refers to the parent cpd
4-phenylbutyric acid : A monocarboxylic acid the structure of which is that of butyric acid substituted with a phenyl group at C-4. It is a histone deacetylase inhibitor that displays anticancer activity. It inhibits cell proliferation, invasion and migration and induces apoptosis in glioma cells. It also inhibits protein isoprenylation, depletes plasma glutamine, increases production of foetal haemoglobin through transcriptional activation of the gamma-globin gene and affects hPPARgamma activation.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Though the treatment was successful in ameliorating hyperammonemia, hyperargininemia persisted." | 3.96 | Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency. ( Fukui, K; Hanai, T; Ishibashi, H; Matsufuji, M; Nakashima, M; Takashima, S; Takeshita, E; Watanabe, Y, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsufuji, M | 1 |
| Takeshita, E | 1 |
| Nakashima, M | 1 |
| Watanabe, Y | 1 |
| Fukui, K | 1 |
| Hanai, T | 1 |
| Ishibashi, H | 1 |
| Takashima, S | 1 |
1 other study available for 4-phenylbutyric acid and ARG1 Deficiency
| Article | Year |
|---|---|
Sodium phenylbutyrate improved the clinical state in an adult patient with arginase 1 deficiency.
Topics: Adult; Arginase; Arginine; Female; Humans; Hyperammonemia; Hyperargininemia; Phenylbutyrates | 2020 |