4-oxothiazolidine and Adenocarcinoma

4-oxothiazolidine has been researched along with Adenocarcinoma* in 1 studies

Other Studies

1 other study(ies) available for 4-oxothiazolidine and Adenocarcinoma

ArticleYear
First Synthesis of Novel Aminophenyl Pyridinium-5-(hydroxybenzoyl)-hydrazonomethyl-2-oxothiazol-3-ide Derivatives and Evaluation of Their Anticancer Activities.
    Chemical & pharmaceutical bulletin, 2015, Volume: 63, Issue:10

    The first total synthesis for large-scale production and anticancer activity of novel aminophenylpyridinium-5-(hydroxybenzoyl)hydrazonomethyl-2-oxothiazol-3-ide (PBHT) (1) and its derivatives are reported. The chemical structure of PBHT was unambiguously determined by utilization of the two-dimensional nuclear Overhauser effect (NOE) technique. The anticancer activity against human colon adenocarcinoma (HCT15) cells of all synthesized compounds was approximately four-fold greater than that of 5-fluorouracil, with IC50 values ranging from 10.1 to 14.2 µM. The three structural determinants of hydroxybenzoyl, hydrazinylidene, and pyridinium oxothiazole in the synthesized compounds could be indispensable for exhibiting anticancer activity.

    Topics: Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Pyridinium Compounds; Structure-Activity Relationship; Thiazoles

2015
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