Page last updated: 2024-10-21

4-nonylphenol and Pregnancy

4-nonylphenol has been researched along with Pregnancy in 22 studies

4-nonylphenol: structure in first source; see also record for nonylphenol
4-nonylphenol : A member of the class of phenols that is phenol which is para-substituted with a nonyl group.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
" Pregnant mice were dosed by gavage with vehicle or 4-NP (0."5.38The endocrine disruptor 4-nonylphenol promotes adipocyte differentiation and induces obesity in mice. ( Cheng, XJ; Hao, CJ; Ma, X; Xia, HF, 2012)
"Human 3β-hydroxysteroid dehydrogenase type I (HSD3B1) and rat type IV (HSD3B4) in placentas catalyze the conversion of pregnenolone to progesterone, which plays a key role in maintaining pregnancy."4.31Effects of phenolic compounds on 3β-hydroxysteroid dehydrogenase activity in human and rat placenta: Screening, mode of action, and docking analysis. ( Ge, RS; Hu, Z; Li, H; Li, J; Meng, F; Shi, L; Tian, F; Wang, H; Wang, S; Wang, Y; Zhu, Y, 2023)
"Maternal exposure to 4-nonylphenol (4-NP) during pregnancy was shown to alter adipogenesis in rodents, yet whether the effects are restricted to 4-NP-exposed offspring only or can be transmitted to the next generation are not known."3.80Perinatal exposure to 4-nonylphenol affects adipogenesis in first and second generation rats offspring. ( Huo, WQ; Li, YY; Ma, Y; Xia, W; Xu, B; Xu, SQ; Xue, WY; Zhang, HY; Zhu, YS, 2014)
" Pregnant mice were dosed by gavage with vehicle or 4-NP (0."1.38The endocrine disruptor 4-nonylphenol promotes adipocyte differentiation and induces obesity in mice. ( Cheng, XJ; Hao, CJ; Ma, X; Xia, HF, 2012)
"The distribution and the metabolic fate of 4-n-nonylphenol were investigated in male and female Wistar rats dosed orally with 1 microg/kg ("low-dose") or 10 mg/kg ("high-dose") labeled 4-n-nonylphenol."1.32In vivo metabolic fate of the xeno-estrogen 4-n-nonylphenol in Wistar rats. ( Costagliola, R; Cravedi, JP; Dorio, C; Rathahao, E; Zalko, D, 2003)
"We previously performed dose-response studies of genistein, diisononyl phthalate, 4-nonylphenol, methoxychlor (MXC), and bisphenol A to examine the impact of maternal dietary exposure from gestational day 15 to postnatal day 10 on the development of rat reproductive system in later life."1.32Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals. ( Hirose, M; Lee, KY; Masutomi, N; Shibutani, M; Takagi, H; Uneyama, C, 2004)
"Severe polycystic kidney disease (PKD) was present in 100% of the 2000 ppm-exposed male and female rats."1.31Polycystic kidney disease induced in F(1) Sprague-Dawley rats fed para-nonylphenol in a soy-free, casein-containing diet. ( Delclos, KB; Latendresse, JR; Newbold, RR; Weis, CC, 2001)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (13.64)18.2507
2000's6 (27.27)29.6817
2010's9 (40.91)24.3611
2020's4 (18.18)2.80

Authors

AuthorsStudies
Xiang, R1
Yan, J1
Cheng, S1
Yang, Y1
Wang, H2
Xie, J1
Zhang, L1
Chen, J1
Shi, L1
Meng, F1
Wang, S1
Hu, Z1
Li, J1
Tian, F1
Zhu, Y1
Wang, Y2
Ge, RS1
Li, H1
Zhang, H2
Ke, W1
Chen, X1
Han, Y1
Xiong, Y1
Zhu, F1
Xiang, Y1
Yan, R1
Cai, H1
Huang, S1
Ke, X1
Cai, JX1
Li, Z1
Dai, J1
Wang, XL1
Cheng, JX1
Nehring, I1
Grajewska, A1
Falkowska, L1
Staniszewska, M1
Pawliczka, I1
Saniewska, D1
Patiño-García, D1
Cruz-Fernandes, L1
Buñay, J1
Palomino, J1
Moreno, RD1
Zhang, HY1
Xue, WY1
Li, YY1
Ma, Y1
Zhu, YS1
Huo, WQ1
Xu, B1
Xia, W1
Xu, SQ1
Vo, TT1
Nguyen, PV1
Duong, HT1
Nguyen, TD1
Huynh, HT1
Nong, HV1
Sieppi, E1
Vähäkangas, K1
Rautio, A1
Ietta, F3
Paulesu, L3
Myllynen, P1
Shekhar, S1
Sood, S1
Showkat, S1
Lite, C1
Chandrasekhar, A1
Vairamani, M1
Barathi, S1
Santosh, W1
Bechi, N2
Romagnoli, R2
Jantra, S1
Cencini, M1
Galassi, G1
Serchi, T1
Corsi, I2
Focardi, S2
Balakrishnan, B1
Thorstensen, E1
Ponnampalam, A1
Mitchell, MD1
Hao, CJ1
Cheng, XJ1
Xia, HF1
Ma, X1
Zalko, D2
Costagliola, R1
Dorio, C1
Rathahao, E1
Cravedi, JP2
Masutomi, N1
Shibutani, M1
Takagi, H1
Uneyama, C1
Lee, KY1
Hirose, M1
Buffi, C1
Savouret, JF1
Menuet, A1
Jégou, B1
Nagel, SC1
vom Saal, FS1
Thayer, KA1
Dhar, MG1
Boechler, M1
Welshons, WV1
Korsgaard, B1
Pedersen, KL1
Chapin, RE1
Delaney, J1
Lanning, L1
Davis, B1
Collins, B1
Mintz, N1
Wolfe, G1
Latendresse, JR1
Newbold, RR1
Weis, CC1
Delclos, KB1
Dalgaard, M1
Pilegaard, K1
Ladefoged, O1

Reviews

1 review available for 4-nonylphenol and Pregnancy

ArticleYear
[The concept of endocrine disruption and human health].
    Medecine sciences : M/S, 2007, Volume: 23, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Benzhydryl Compounds; Diethylstilbestrol; Endocrine Disruptors

2007

Other Studies

21 other studies available for 4-nonylphenol and Pregnancy

ArticleYear
Developmental immunotoxicity and its potential gender differences of perinatal exposure to 4-nonylphenol on offspring rats: JAK-STAT signaling pathway involved.
    Ecotoxicology and environmental safety, 2022, Jun-01, Volume: 237

    Topics: Animals; Biological Phenomena; Female; Humans; Janus Kinases; Male; Phenols; Pregnancy; Rats; Rats,

2022
Effects of phenolic compounds on 3β-hydroxysteroid dehydrogenase activity in human and rat placenta: Screening, mode of action, and docking analysis.
    The Journal of steroid biochemistry and molecular biology, 2023, Volume: 225

    Topics: 3-Hydroxysteroid Dehydrogenases; Animals; Female; Humans; Molecular Docking Simulation; Multienzyme

2023
High-Fat Diet Promotes Adipogenesis in Offspring Female Rats Induced by Perinatal Exposure to 4-Nonylphenol.
    BioMed research international, 2023, Volume: 2023

    Topics: Adipogenesis; Adipose Tissue; Animals; Diet, High-Fat; Female; Humans; Phenols; Pregnancy; Prenatal

2023
[4-nonylphenol combined with bisphenol A induces testicular autophagy and spermatogenic impairment by inhibiting the Akt/mTOR pathway in F1 male offspring rats].
    Zhonghua nan ke xue = National journal of andrology, 2022, Volume: 28, Issue:3

    Topics: Animals; Autophagy; Benzhydryl Compounds; Female; Male; Pregnancy; Proto-Oncogene Proteins c-akt; Ra

2022
Transfer of mercury and phenol derivatives across the placenta of Baltic grey seals (Halichoerus grypus grypus).
    Environmental pollution (Barking, Essex : 1987), 2017, Volume: 231, Issue:Pt 1

    Topics: Animals; Baltic States; Benzhydryl Compounds; Endocrine Disruptors; Environmental Monitoring; Female

2017
Reproductive Alterations in Chronically Exposed Female Mice to Environmentally Relevant Doses of a Mixture of Phthalates and Alkylphenols.
    Endocrinology, 2018, 02-01, Volume: 159, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Endocrine Disruptors; Environmental Exposure; Female; Mat

2018
Perinatal exposure to 4-nonylphenol affects adipogenesis in first and second generation rats offspring.
    Toxicology letters, 2014, Mar-03, Volume: 225, Issue:2

    Topics: Adipocytes; Adipogenesis; Adipose Tissue; Animals; Body Weight; Cholesterol; Estrogen Receptor alpha

2014
Potential effect of combined xenoestrogens during gestation stages on mouse offspring.
    Journal of environmental biology, 2015, Volume: 36, Issue:2

    Topics: Animals; Benzhydryl Compounds; Dose-Response Relationship, Drug; Drug Synergism; Environmental Pollu

2015
The xenoestrogens, bisphenol A and para-nonylphenol, decrease the expression of the ABCG2 transporter protein in human term placental explant cultures.
    Molecular and cellular endocrinology, 2016, 07-05, Volume: 429

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Benzhydryl Compounds; Cells, Cultured; Chor

2016
Detection of phenolic endocrine disrupting chemicals (EDCs) from maternal blood plasma and amniotic fluid in Indian population.
    General and comparative endocrinology, 2017, 01-15, Volume: 241

    Topics: Adult; Amniotic Fluid; Benzhydryl Compounds; Blood Chemical Analysis; Endocrine Disruptors; Environm

2017
Environmental levels of para-nonylphenol are able to affect cytokine secretion in human placenta.
    Environmental health perspectives, 2010, Volume: 118, Issue:3

    Topics: Cytokines; Environmental Pollutants; Female; Humans; Interferon-gamma; Interleukins; Phenols; Placen

2010
Passage of 4-nonylphenol across the human placenta.
    Placenta, 2011, Volume: 32, Issue:10

    Topics: Biological Transport; Chromatography, High Pressure Liquid; Endocrine Disruptors; Female; Humans; Ph

2011
The endocrine disruptor 4-nonylphenol promotes adipocyte differentiation and induces obesity in mice.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2012, Volume: 30, Issue:2

    Topics: 3T3-L1 Cells; Adipogenesis; Animals; Animals, Newborn; Blood Glucose; Body Weight; Cell Differentiat

2012
In vivo metabolic fate of the xeno-estrogen 4-n-nonylphenol in Wistar rats.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:2

    Topics: Animals; Estrogens; Female; Male; Phenols; Pregnancy; Rats; Rats, Wistar; Tissue Distribution; Xenob

2003
Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals.
    Archives of toxicology, 2004, Volume: 78, Issue:4

    Topics: Administration, Oral; Age Factors; Animals; Benzhydryl Compounds; Diet; Estrogens, Non-Steroidal; Fe

2004
Estrogen-like response to p-nonylphenol in human first trimester placenta and BeWo choriocarcinoma cells.
    Toxicological sciences : an official journal of the Society of Toxicology, 2006, Volume: 93, Issue:1

    Topics: Apoptosis; Cell Line, Tumor; Choriocarcinoma; Electrophoresis, Polyacrylamide Gel; Estrogens; Female

2006
Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol.
    Environmental health perspectives, 1997, Volume: 105, Issue:1

    Topics: Animals; Benzhydryl Compounds; Breast Neoplasms; Estrogens, Non-Steroidal; Female; Humans; Male; Mic

1997
Vitellogenin in Zoarces viviparus: purification, quantification by ELISA and induction by estradiol-17 beta and 4-nonylphenol.
    Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1998, Volume: 120, Issue:1

    Topics: Animals; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; Fishes; Male; Phenols; Pregnancy; Rab

1998
The effects of 4-nonylphenol in rats: a multigeneration reproduction study.
    Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 52, Issue:1

    Topics: Animals; Diet; Dose-Response Relationship, Drug; Female; Male; Phenols; Pregnancy; Prenatal Exposure

1999
Polycystic kidney disease induced in F(1) Sprague-Dawley rats fed para-nonylphenol in a soy-free, casein-containing diet.
    Toxicological sciences : an official journal of the Society of Toxicology, 2001, Volume: 62, Issue:1

    Topics: Animals; Animals, Newborn; Body Weight; Caseins; Diet; Dose-Response Relationship, Drug; Eating; Fem

2001
In utero exposure to diethylstilboestrol or 4-n-nonylphenol in rats: number of sertoli cells, diameter and length of seminiferous tubules estimated by stereological methods.
    Pharmacology & toxicology, 2002, Volume: 90, Issue:2

    Topics: Administration, Oral; Animals; Cell Count; Diethylstilbestrol; Female; Male; Models, Anatomic; Pheno

2002