4-nitroquinoline-1-oxide has been researched along with Xeroderma Pigmentosum in 41 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
Xeroderma Pigmentosum: A rare, pigmentary, and atrophic autosomal recessive disease. It is manifested as an extreme photosensitivity to ULTRAVIOLET RAYS as the result of a deficiency in the enzyme that permits excisional repair of ultraviolet-damaged DNA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of the UV-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) upon cell lines heterozygous or homozygous for the recessive mutant xeroderma pigmentosum (XP) were investigated." | 7.68 | An improved method for the detection of differential survival between normal and xeroderma pigmentosum lymphoblastoid cell lines in culture with 4-nitroquinoline-1-oxide. ( Hirohata, T; Kiyohara, C; Kuratsune, M; Nagayama, J, 1991) |
| "The data in this paper show that when the inhibition of growth is measured, xeroderma pigmentosum (XP) complementation groups A, G and D are very sensitive to 4-nitroquinoline-1-oxide (4NQO), whereas only XP groups G and D are very sensitive to 3-methyl-4NQO (3me4NQO)." | 7.67 | The response to DNA damage induced by 4-nitroquinoline-1-oxide or its 3-methyl derivative in xeroderma pigmentosum fibroblasts belonging to different complementation groups: evidence for different epistasis groups involved in the repair of large adducts i ( Edwards, S; Fielding, S; Waters, R, 1987) |
| "The effect of 4-nitroquinoline-1-oxide (4NQO) upon 3 fibroblast cell lines derived from normal and xeroderma pigmentosum subjects have been compared." | 7.66 | Repair of 4-nitroquinoline-1-oxide-induced DNA damage in normal human cells and cells from classical and variant xeroderma pigmentosum. ( Dollery, AA; Harris, WJ; Keir, HM; Melvin, WT, 1983) |
| "Unscheduled DNA synthesis (UDS) induced by 4-nitroquinoline-1-oxide (rNQO) in the complementation groups A to E and variant xeroderma pigmentosum (XP) cells, and various pairs of complementing XP heterokaryons were investigated." | 7.66 | Unscheduled DNA synthesis induced by 4-nitroquinoline-1-oxide in xeroderma pigmentosum cells and their complementing heterodikaryons. ( Okada, Y; Takebe, H; Tanaka, K, 1980) |
| "4-Nitroquinoline-1-oxide (4NQO) damage to DNA and its repair in normal and xeroderma pigmentosum (XP) fibroblast stains were followed by sedimentation in an alkaline sucrose gradient." | 7.66 | Alkaline sucrose sedimentation analysis as an indicator of repair capability of xeroderma pigmentosum fibroblasts for 4-nitroquinoline-1-oxide damage. ( Walker, IG, 1981) |
| " The cytotoxicity and genotoxicity of UV-irradiation and the chemical mutagens 4-nitroquinoline-1-oxide (4NQO), benzo[a]pyrene (BP) and 7,12-dimethyl-benz[a]anthracene (DMBA) were compared in a normal human cell line (MRC5CV1) and an excision-deficient xeroderma pigmentosum (XP) cell line (XP12ROSV)." | 3.69 | The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay). ( Hartmann, A; Speit, G, 1995) |
| " In this study, we performed both assays in 16 established lymphoblastoid cell lines derived from patients with xeroderma pigmentosum (n = 3), ataxia telangiectasia (n = 2), head and neck cancer (n = 3), and melanoma (n = 2), and from normal human subjects (n = 6) using UV light, 4-nitroquinoline-1-oxide (4-NQO; an UV-mimetic agent), and gamma-irradiation as the test agents." | 3.69 | DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines. ( Cheng, L; Gu, J; Hsu, TC; Kripke, ML; Spitz, MR; Strom, SS; Wei, Q; Xu, X, 1996) |
| "The effects of the UV-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) upon cell lines heterozygous or homozygous for the recessive mutant xeroderma pigmentosum (XP) were investigated." | 3.68 | An improved method for the detection of differential survival between normal and xeroderma pigmentosum lymphoblastoid cell lines in culture with 4-nitroquinoline-1-oxide. ( Hirohata, T; Kiyohara, C; Kuratsune, M; Nagayama, J, 1991) |
| "Lymphoblastoid cell lines established from three unrelated kindreds with familial melanoma (FM) were cytogenetically analyzed for spontaneous and 4-nitroquinoline-1-oxide (4NQO)-induced chromosome aberrations." | 3.67 | Spontaneous and 4-nitroquinoline 1-oxide-induced G2 chromosome aberrations in lymphoblasts from familial melanoma patients. ( Hayward, NK; Lu, GH; Stanley, WS, 1989) |
| "DNA repair synthesis and strand break DNA repair induced by 4-nitroquinoline-1-oxide and UV-irradiation in Xeroderma pigmentosum lymphocytes and fibroblasts pretreated by leucocyte interferons were studied." | 3.67 | [Mechanisms of impairment of DNA repair in human cells. Interferons stimulated DNA repair in xeroderma pigmentosum cells]. ( Chekova, VV; Sinel'shchikova, TA; Zasukhina, GD, 1989) |
| "The data in this paper show that when the inhibition of growth is measured, xeroderma pigmentosum (XP) complementation groups A, G and D are very sensitive to 4-nitroquinoline-1-oxide (4NQO), whereas only XP groups G and D are very sensitive to 3-methyl-4NQO (3me4NQO)." | 3.67 | The response to DNA damage induced by 4-nitroquinoline-1-oxide or its 3-methyl derivative in xeroderma pigmentosum fibroblasts belonging to different complementation groups: evidence for different epistasis groups involved in the repair of large adducts i ( Edwards, S; Fielding, S; Waters, R, 1987) |
| "Excision repair was measured in normal human and xeroderma pigmentosum group C fibroblasts treated with ultraviolet radiation and the carcinogens acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide (4NQO) by the techniques of unscheduled synthesis, photolysis of bromodeoxyuridine incorporated into parental DNA during repair, and assays of sites sensitive to ultraviolet (UV)-endonuclease." | 3.66 | DNA excision in repair proficient and deficient human cells treated with a combination of ultraviolet radiation and acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide. ( Ahmed, FE; Setlow, RB, 1980) |
| "The effect of 4-nitroquinoline-1-oxide (4NQO) upon 3 fibroblast cell lines derived from normal and xeroderma pigmentosum subjects have been compared." | 3.66 | Repair of 4-nitroquinoline-1-oxide-induced DNA damage in normal human cells and cells from classical and variant xeroderma pigmentosum. ( Dollery, AA; Harris, WJ; Keir, HM; Melvin, WT, 1983) |
| "Unscheduled DNA synthesis (UDS) induced by 4-nitroquinoline-1-oxide (rNQO) in the complementation groups A to E and variant xeroderma pigmentosum (XP) cells, and various pairs of complementing XP heterokaryons were investigated." | 3.66 | Unscheduled DNA synthesis induced by 4-nitroquinoline-1-oxide in xeroderma pigmentosum cells and their complementing heterodikaryons. ( Okada, Y; Takebe, H; Tanaka, K, 1980) |
| "4-Nitroquinoline-1-oxide (4NQO) damage to DNA and its repair in normal and xeroderma pigmentosum (XP) fibroblast stains were followed by sedimentation in an alkaline sucrose gradient." | 3.66 | Alkaline sucrose sedimentation analysis as an indicator of repair capability of xeroderma pigmentosum fibroblasts for 4-nitroquinoline-1-oxide damage. ( Walker, IG, 1981) |
| "In order to develop the usefulness of Fanconi's anemia (FA) lymphoblast lines for biochemical and genetic studies, we have determined their sensitivity to a variety of DNA-damaging chemicals." | 1.26 | Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents. ( Buchwald, M; Ishida, R, 1982) |
| "The frequency of metaphase plates with chromosome aberrations and the frequency of breaks and exchanges per chromosome complement were estimated following exposure to the carcinogens 4-nitroquinoline-1-oxide (4NQO),N-acetoxy-2-acetyl-aminofluorene (N-acetoxy-2-AAF), and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), and to the mutagen daunomycin." | 1.26 | Differential sensitivity of Xeroderma pigmentosum cells of different repair capacities towards the chromosome breaking action of carcinogens and mutagens. ( San, RH; Stich, HF; Stich, W, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (78.05) | 18.7374 |
| 1990's | 9 (21.95) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmed, FE | 1 |
| Setlow, RB | 1 |
| Tanaka, H | 2 |
| Orii, T | 2 |
| Dollery, AA | 1 |
| Melvin, WT | 1 |
| Keir, HM | 1 |
| Harris, WJ | 1 |
| Suzuki, N | 1 |
| Khachapuridze, GG | 1 |
| Mikhel'son, VM | 1 |
| Zhestianikov, VD | 1 |
| Zelle, B | 1 |
| Bootsma, D | 1 |
| Tanaka, K | 2 |
| Takebe, H | 4 |
| Okada, Y | 2 |
| Walker, IG | 1 |
| Mirzayans, R | 4 |
| Waters, R | 4 |
| Sivak, A | 1 |
| Rudenko, L | 1 |
| Teague, LG | 1 |
| Ishida, R | 1 |
| Buchwald, M | 1 |
| Ito, T | 1 |
| Zasukhina, GD | 4 |
| L'vova, GN | 3 |
| Chekova, VV | 3 |
| Prokhorov, AIu | 2 |
| Mordovtsev, VN | 1 |
| Payne, A | 1 |
| Chu, G | 1 |
| Moriwaki, S | 1 |
| Nishigori, C | 1 |
| Teramoto, T | 1 |
| Tanaka, T | 1 |
| Kore-eda, S | 1 |
| Imamura, S | 1 |
| Speit, G | 1 |
| Hartmann, A | 1 |
| Wei, Q | 1 |
| Spitz, MR | 1 |
| Gu, J | 1 |
| Cheng, L | 1 |
| Xu, X | 1 |
| Strom, SS | 1 |
| Kripke, ML | 1 |
| Hsu, TC | 1 |
| Sinel'shchikova, TA | 2 |
| Chang, KS | 1 |
| Hayakawa, H | 1 |
| Sekiguchi, M | 1 |
| San, RH | 1 |
| Stich, W | 1 |
| Stich, HF | 1 |
| Ikenaga, M | 2 |
| Ishii, Y | 1 |
| Kakunaga, T | 1 |
| Nagao, M | 1 |
| Sugimura, T | 1 |
| Kiyohara, C | 2 |
| Hirohata, T | 2 |
| Kuratsune, M | 2 |
| Nagayama, J | 2 |
| Paterson, MC | 3 |
| Baker, JC | 1 |
| Ames, BN | 1 |
| Shimoi, K | 1 |
| Nakamura, Y | 1 |
| Noro, T | 1 |
| Tomita, I | 1 |
| Sasaki, YF | 1 |
| Imanishi, H | 1 |
| Matsumoto, K | 1 |
| Shirasu, Y | 1 |
| Jones, CJ | 1 |
| Edwards, SM | 1 |
| Lu, GH | 1 |
| Hayward, NK | 1 |
| Stanley, WS | 1 |
| Fujiwara, Y | 2 |
| Zasukhina, RD | 1 |
| Edwards, S | 1 |
| Fielding, S | 1 |
| Cleaver, JE | 1 |
| Cortés, F | 1 |
| Lutze, LH | 1 |
| Morgan, WF | 1 |
| Player, AN | 1 |
| Mitchell, DL | 1 |
| Sinelshchikova, TA | 1 |
| Lvova, GN | 1 |
| Shoniya, NN | 1 |
| Sabour, M | 1 |
| Satoh, Y | 1 |
2 reviews available for 4-nitroquinoline-1-oxide and Xeroderma Pigmentosum
| Article | Year |
|---|---|
[DNA repair and carcinogenesis (author's transl)].
Topics: 4-Nitroquinoline-1-oxide; Adolescent; Adult; Animals; Cell Survival; Child; Deoxyribodipyrimidine Ph | 1978 |
Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Animals; Bacteria; Bacteriophages; Base Sequence; Carcinogens; Ce | 1976 |
1 trial available for 4-nitroquinoline-1-oxide and Xeroderma Pigmentosum
| Article | Year |
|---|---|
[Interferon as a stimulator of DNA repair in patients with xeroderma pigmentosum].
Topics: 4-Nitroquinoline-1-oxide; DNA Repair; Etretinate; Heterozygote; Humans; Interferons; Mutagenesis; Ul | 1993 |
38 other studies available for 4-nitroquinoline-1-oxide and Xeroderma Pigmentosum
| Article | Year |
|---|---|
DNA excision in repair proficient and deficient human cells treated with a combination of ultraviolet radiation and acridine mustard (ICR-170) or 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Bromodeoxyuridine; Cells, Cultured; DNA; DNA Repair; Endonucleases; Fibrob | 1980 |
High sensitivity but normal DNA-repair activity after UV irradiation in Epstein--Barr virus-transformed lymphoblastoid cell lines from Chediak--Higashi syndrome.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Transformation, Viral; Chediak-Higashi Syndrome; DNA; DNA | 1980 |
Repair of 4-nitroquinoline-1-oxide-induced DNA damage in normal human cells and cells from classical and variant xeroderma pigmentosum.
Topics: 4-Nitroquinoline-1-oxide; Cell Survival; Cells, Cultured; DNA Repair; DNA Replication; Humans; Nitro | 1983 |
A UV-resistant mutant without an increased repair synthesis activity, established from a UV-sensitive human clonal cell line.
Topics: 4-Nitroquinoline-1-oxide; Cell Cycle; Cell Line; Cell Survival; Clone Cells; DNA Repair; DNA Replica | 1984 |
[Number of chromosome aberrations induced by chemical carcinogens in the cells of patients with 2 forms of xeroderma pigmentosum].
Topics: 4-Nitroquinoline-1-oxide; Benz(a)Anthracenes; Carcinogens; Cell Cycle; Chromosome Aberrations; Human | 1980 |
Repair of DNA damage after exposure to 4-nitroquinoline-1-oxide in heterokaryons derived from xeroderma pigmentosum cells.
Topics: 4-Nitroquinoline-1-oxide; Cell Fusion; Cell Line; Cell Nucleus; DNA; DNA Repair; Genetic Complementa | 1980 |
Unscheduled DNA synthesis induced by 4-nitroquinoline-1-oxide in xeroderma pigmentosum cells and their complementing heterodikaryons.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; DNA; DNA Repair; DNA Replication; Dose-Response Relationship, D | 1980 |
Alkaline sucrose sedimentation analysis as an indicator of repair capability of xeroderma pigmentosum fibroblasts for 4-nitroquinoline-1-oxide damage.
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; Centrifugation, Density Gradient; DNA Repair; Fibroblasts | 1981 |
DNA damage and its repair in human normal or xeroderma pigmentosum fibroblasts treated with 4-nitroquinoline 1-oxide or its 3-methyl derivative.
Topics: 4-Nitroquinoline-1-oxide; Cell Division; Cell Line; Cells, Cultured; DNA Repair; DNA Replication; Fi | 1981 |
Variations among species and cell types in the effects of caffeine on mutagen-induced cytotoxicity and postreplication repair of DNA.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Line; Cell Survival; Cricet | 1982 |
Susceptibility of Fanconi's anemia lymphoblasts to DNA-cross-linking and alkylating agents.
Topics: 4-Nitroquinoline-1-oxide; Alkylating Agents; Anemia, Aplastic; Antibiotics, Antineoplastic; Carcinog | 1982 |
DNA repair mechanisms in Chediak--Higashi syndrome cells.
Topics: 4-Nitroquinoline-1-oxide; Caffeine; Chediak-Higashi Syndrome; DNA; DNA Repair; Fibroblasts; Humans; | 1982 |
Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage.
Topics: 4-Nitroquinoline-1-oxide; Cisplatin; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Genetic Comp | 1994 |
Absence of DNA repair deficiency in the confirmed heterozygotes of xeroderma pigmentosum group A.
Topics: 4-Nitroquinoline-1-oxide; Base Sequence; Child, Preschool; DNA; DNA Repair; Heterozygote; Humans; In | 1993 |
The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay).
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Aphidicolin; Benzo(a)pyrene; Cell Surviv | 1995 |
DNA repair capacity correlates with mutagen sensitivity in lymphoblastoid cell lines.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Biomarkers; Carcinogens; Cell Line; Chromatids; Chr | 1996 |
[Enhanced reactivation and induced mutagenesis of vaccinia virus in repair-defective cells of homocystinuria].
Topics: 4-Nitroquinoline-1-oxide; DNA Damage; DNA Repair; DNA, Viral; Fibroblasts; Gamma Rays; Homocystinuri | 1996 |
Susceptibility of xeroderma pigmentosum cells to transformation by murine and feline sarcoma viruses.
Topics: 4-Nitroquinoline-1-oxide; Age Factors; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; | 1976 |
Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Coliphages; DNA; DNA Repair; Endonucleases; Genes; Humans; Para | 1977 |
Differential sensitivity of Xeroderma pigmentosum cells of different repair capacities towards the chromosome breaking action of carcinogens and mutagens.
Topics: 4-Nitroquinoline-1-oxide; Acetoxyacetylaminofluorene; Carcinogens; Cells, Cultured; Chromosome Aberr | 1977 |
Excision repair of DNA base damage in human cells treated with the chemical carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Amnion; Cell Line; DNA; DNA Repair; DNA, Neoplasm; Guanine; Human | 1977 |
Excision of 4-nitroquinoline 1-oxide damage and transformed in mouse cells.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; DNA | 1977 |
Distribution of sensitivity to 4-nitroquinoline 1-oxide among Japanese lymphoblastoid cell lines.
Topics: 4-Nitroquinoline-1-oxide; Adolescent; Adult; Child; Child, Preschool; Fluorescein; Fluoresceins; Hum | 1991 |
An improved method for the detection of differential survival between normal and xeroderma pigmentosum lymphoblastoid cell lines in culture with 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Cell Division; Cell Line; Cell Survival; Heterozygote; Homozygote; Humans; | 1991 |
Differential repair of 1-beta-D-arabinofuranosylcytosine-detectable sites in DNA of human fibroblasts exposed to ultraviolet light and 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Centrifugation, Density Gradient; Cytarabine; DNA Damage; DNA R | 1991 |
Alterations in levels of 5'-adenyl dinucleotides following DNA damage in normal human fibroblasts and fibroblasts derived from patients with xeroderma pigmentosum.
Topics: 4-Nitroquinoline-1-oxide; Adenine Nucleotides; Bleomycin; Cytarabine; Dinucleoside Phosphates; DNA D | 1988 |
Enhancing effects of cinoxate and methyl sinapate on the frequencies of sister-chromatid exchanges and chromosome aberrations in cultured mammalian cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Chromosome Aberrations; Cinnamates; Cricetinae; DNA Re | 1989 |
The repair of identified large DNA adducts induced by 4-nitroquinoline-1-oxide in normal or xeroderma pigmentosum group A human fibroblasts, and the role of DNA polymerases alpha or delta.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Survival; DNA; DNA Polymerase II; DNA Polymerase III; DNA | 1989 |
Spontaneous and 4-nitroquinoline 1-oxide-induced G2 chromosome aberrations in lymphoblasts from familial melanoma patients.
Topics: 4-Nitroquinoline-1-oxide; Chromosome Aberrations; Humans; Interphase; Lymphocytes; Melanoma; Neoplas | 1989 |
Clustered repair of excisable 4-nitroquinoline-1-oxide adducts in a larger fraction of genomic DNA of xeroderma pigmentosum complementation group C cells.
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; DNA; DNA Repair; DNA Replication; Fibroblasts; Humans; Ki | 1989 |
[Mechanisms of disruption of DNA in human cells. Mutagenesis of a virus in xeroderma pigmentosum cells as an indicator of a defect in DNA repair].
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; DNA Repair; Female; Fibroblasts; Genes, Viral; Humans; Ly | 1989 |
[Mechanisms of impairment of DNA repair in human cells. Interferons stimulated DNA repair in xeroderma pigmentosum cells].
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; DNA Damage; DNA Repair; Fibroblasts; Humans; Interferon T | 1989 |
The response to DNA damage induced by 4-nitroquinoline-1-oxide or its 3-methyl derivative in xeroderma pigmentosum fibroblasts belonging to different complementation groups: evidence for different epistasis groups involved in the repair of large adducts i
Topics: 4-Nitroquinoline-1-oxide; Aphidicolin; Catalase; Cell Line; Diterpenes; DNA Damage; DNA Repair; Epis | 1987 |
Unique DNA repair properties of a xeroderma pigmentosum revertant.
Topics: 4-Nitroquinoline-1-oxide; Cell Line, Transformed; DNA Repair; Humans; Methylnitronitrosoguanidine; M | 1987 |
Defective DNA excision repair in cells of patients with homocystinuria.
Topics: 4-Nitroquinoline-1-oxide; Cells, Cultured; DNA Damage; DNA Repair; Fibroblasts; Gamma Rays; HeLa Cel | 1987 |
Enhanced bioreduction of 4-nitroquinoline 1-oxide by cultured ataxia telangiectasia cells.
Topics: 4-Nitroquinoline-1-oxide; Ataxia Telangiectasia; Biotransformation; Cells, Cultured; DNA Damage; DNA | 1988 |
Defective repair of a class of 4NQO-induced alkali-labile DNA lesions in xeroderma pigmentosum complementation group A fibroblasts.
Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; DNA Repair; Fibroblasts; Humans; Nitroqui | 1985 |
Assignment of two Japanese xeroderma pigmentosum patients to complementation group D and their characteristics.
Topics: 4-Nitroquinoline-1-oxide; Autoradiography; Cell Fusion; Cells, Cultured; Child; Chromosomes, Human, | 1985 |