4-nitroquinoline-1-oxide has been researched along with Hyperplasia in 25 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis." | 1.91 | GPR68 limits the severity of chemical-induced oral epithelial dysplasia. ( Amin, ARMR; Graffeo, V; Griggs, N; McAleer, JP; Shore, D; Xu, Y; Zha, XM, 2023) |
| "Lycopene treatment significantly decreased the incidence of 4-NQO induced tongue carcinogenesis." | 1.37 | Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide. ( El-Rouby, DH, 2011) |
| "In pre-neoplastic lesions and squamous cell carcinomas induced after 12 and 20 weeks following carcinogen exposure, respectively, oxidative DNA damage was also increased (P < 0." | 1.37 | Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Carvalho, JG; Miranda, SR; Noguti, J; Oshima, CT; Ribeiro, DA, 2011) |
| "Esophageal and tongue cancers have both been associated with dietary zinc deficiency (ZD), and cyclooxygenase (COX-2) is often overexpressed in these cancers." | 1.33 | Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats. ( Farber, JL; Fong, LY; Jiang, Y; Zhang, L, 2005) |
| "Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated." | 1.32 | Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Kadota, H; Kakudo, K; Sakaki, T; Tamura, I, 2003) |
| "The papillomas are heterogeneous in their potential for progression to carcinomas, a property apparently induced at the time of initiation." | 1.28 | Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin. ( Hennings, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (16.00) | 18.7374 |
| 1990's | 12 (48.00) | 18.2507 |
| 2000's | 3 (12.00) | 29.6817 |
| 2010's | 5 (20.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shore, D | 1 |
| Griggs, N | 1 |
| Graffeo, V | 1 |
| Amin, ARMR | 1 |
| Zha, XM | 1 |
| Xu, Y | 1 |
| McAleer, JP | 1 |
| Rosin, FC | 1 |
| Barcessat, AR | 1 |
| Borges, GG | 1 |
| Corrêa, L | 1 |
| Vered, M | 1 |
| Grinstein-Koren, O | 1 |
| Reiter, S | 1 |
| Allon, I | 1 |
| Dayan, D | 1 |
| El-Rouby, DH | 1 |
| Miranda, SR | 1 |
| Noguti, J | 1 |
| Carvalho, JG | 1 |
| Oshima, CT | 1 |
| Ribeiro, DA | 1 |
| Moon, SM | 1 |
| Ahn, MY | 1 |
| Kwon, SM | 1 |
| Kim, SA | 1 |
| Ahn, SG | 1 |
| Yoon, JH | 1 |
| Sakaki, T | 1 |
| Tamura, I | 1 |
| Kadota, H | 1 |
| Kakudo, K | 1 |
| Yamamoto, K | 1 |
| Kitayama, W | 1 |
| Denda, A | 1 |
| Morisaki, A | 1 |
| Kuniyasu, H | 1 |
| Kirita, T | 1 |
| Fong, LY | 1 |
| Zhang, L | 1 |
| Jiang, Y | 1 |
| Farber, JL | 1 |
| Fisker, AV | 2 |
| Philipsen, HP | 2 |
| Wilson, DF | 1 |
| Vreugdenburg, A | 1 |
| Wiebkin, OW | 1 |
| Yamamoto, Y | 2 |
| Itoh, T | 1 |
| Takahashi, H | 2 |
| Inoue, I | 1 |
| Ito, T | 5 |
| Tanaka, T | 4 |
| Kojima, T | 3 |
| Hara, A | 1 |
| Sawada, H | 1 |
| Mori, H | 4 |
| Makita, H | 1 |
| Kawabata, K | 1 |
| El-Bayoumy, K | 1 |
| Kawabe, R | 1 |
| Kitamura, H | 4 |
| Inayama, Y | 4 |
| Kanisawa, M | 4 |
| Morishita, Y | 1 |
| Okumura, A | 1 |
| Yoshimi, N | 1 |
| Hennings, H | 1 |
| Shibagaki, T | 1 |
| Hayashi, Y | 1 |
| Tsubakihara, M | 1 |
| Kandarkar, SV | 1 |
| Reade, PC | 1 |
| West, MJ | 1 |
| Andersen, AH | 1 |
| Prime, SS | 1 |
| MacDonald, DG | 1 |
| Sawyer, DR | 1 |
| Rennie, J | 1 |
25 other studies available for 4-nitroquinoline-1-oxide and Hyperplasia
| Article | Year |
|---|---|
GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Ne | 2023 |
Effect of 5-ALA-mediated photodynamic therapy on mast cell and microvessels densities present in oral premalignant lesions induced in rats.
Topics: 4-Nitroquinoline-1-oxide; Aminolevulinic Acid; Animals; Antigens, CD34; Cell Degranulation; Female; | 2015 |
The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Actins; Animals; Carcinoma; Cell Proliferation; Cell Transformation, Neopl | 2010 |
Histological and immunohistochemical evaluation of the chemopreventive role of lycopene in tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Basement Membrane; beta Ca | 2011 |
Oxidative DNA damage is a preliminary step during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Comet Assay; DNA Damage; H | 2011 |
Homeobox C5 expression is associated with the progression of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Li | 2012 |
Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogens; Carcinoma, Squamous Cell; Cell Division; | 2003 |
Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cell Di | 2003 |
Dietary zinc modulation of COX-2 expression and lingual and esophageal carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Blotting, Western; Carcinogens; Carcinoma, Squamous Ce | 2005 |
Verrucous hyperplasia and verrucous carcinoma of the rat oral mucosa. Experimental oral carcinogenesis using 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Papillary; Carcinoma, Squamous Cell; Female; Gingival | 1984 |
Proteoglycan changes in carcinogen (4NQO)-treated rat tongue mucosa.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Body Water; Carcinoma; Connective Tissue | 1995 |
Assessment of bromodeoxyuridine-labeled S-phase cells in experimentally induced precancerous lesions in the rat's tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinoma in Situ; Carcinoma, Squamous Cell; C | 1994 |
Chemoprevention of tongue carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Butylated Hydroxytoluene; Carcinoma, Squ | 1993 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
1,4-phenylenebis(methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Carcinoma, Squa | 1997 |
Modulation of the incidence of hamster pulmonary endocrine cell hyperplasia by unilateral collapse of the lung.
Topics: 4-Nitroquinoline-1-oxide; Animals; APUD Cells; Cricetinae; Hyperplasia; Immunohistochemistry; Incide | 1992 |
Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinoma, Sq | 1992 |
Alterations of the nucleolar organizer regions during 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Division; Epithelial Cells; Hyperp | 1991 |
Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Ce | 1991 |
Preneoplastic changes of xenotransplanted human distal airway epithelium induced by systemic administration of 4-nitroquinoline-1-oxide to host nude mice.
Topics: 4-Nitroquinoline-1-oxide; Aged; Animals; Bronchi; Bronchial Neoplasms; Carcinoembryonic Antigen; Fem | 1991 |
The effect of topical vitamin C on palatal oral mucosal carcinogenesis using 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Ascorbic Acid; Carcinoma, Squamous Cell; | 1991 |
Quantification of oral epithelial hyperplasia in rats after topical application of the carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Epithelium; Hyperplasia; Mouth Mucosa; Neoplasms, Experimental; P | 1990 |
4-Nitroquinoline 1-oxide-induced pulmonary endocrine cell hyperplasia in Syrian golden hamster.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cricetinae; Diethylnitrosamine; Hyperplasia; Lung; Lung Neoplasms | 1986 |
The effect of iron deficiency on early oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinoma, Squamous Cell; Cocarcinogenesis; Hyperpla | 1986 |
Pulmonary adenoma and endocrine cell hyperplasia in Syrian golden hamster treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Adenoma; Animals; Cricetinae; Disease Models, Animal; Endocrine Glands; Hy | 1988 |