4-nitroquinoline-1-oxide has been researched along with Disease Exacerbation in 31 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " To address this gap in knowledge, we conducted preclinical trials using the 4-nitroquinoline-1-oxide 4NQO carcinogen model of oral carcinogenesis." | 3.96 | Impact of dietary vitamin D on initiation and progression of oral cancer. ( DeJong, H; Hershberger, PA; Seshadri, M; Verma, A; Vincent-Chong, VK, 2020) |
| " One week after starting propranolol treatment, all rats were submitted to chemical induction of oral carcinogenesis with 4-nitroquinoline-1-oxide (4NQO)." | 3.96 | Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion. ( Bernabé, DG; Biasoli, ÉR; Cecilio, HP; Furuse, C; Kayahara, GM; Miyahara, GI; Oliveira, SHP; Pereira, KM; Valente, VB, 2020) |
| "This carcinogenesis model was quantitatively evaluated by FI." | 1.51 | Method for diagnosing neoplastic lesions by quantitative fluorescence value. ( Kasahara, M; Kosugi, A; Mori, T; Nakamura-Takahashi, A; Shibahara, T; Yang, L, 2019) |
| "The incidence of extraoral neoplasms was significantly lower (16%) in the younger cohort." | 1.48 | Impact of Age on Disease Progression and Microenvironment in Oral Cancer. ( DeJong, H; Hershberger, PA; Merzianu, M; Patti, A; Rich, LJ; Seshadri, M; Vincent-Chong, VK, 2018) |
| "Regarding oral squamous cell carcinoma (OSCC) development, chewing areca is known to be a strong risk factor in many Asian cultures." | 1.40 | Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma. ( Chang, NW; Chen, CM; Chen, HL; Cheng, JC; Fan, SR; Lai, ZL; Tsai, MH; Tsou, YA, 2014) |
| " Our results indicated that IV dosage of MTX-DOX is more effective than free DOX (12 fold) in inhibiting the activity of MMP-2 in OSCCs (P<0." | 1.40 | Oral and IV dosages of doxorubicin-methotrexate loaded- nanoparticles inhibit progression of oral cancer by down- regulation of matrix Methaloproteinase 2 expression in vivo. ( Abbasi, MM; Hamishehkar, H; Jahanban-Esfahlan, R; Khiavi, MM; Monfaredan, A; Seidi, K, 2014) |
| "The sequencing of the head and neck cancer has provided a blueprint of the most frequent genetic alterations in this cancer type." | 1.39 | PTEN deficiency contributes to the development and progression of head and neck cancer. ( Abrahao, AC; Castilho, RM; Gutkind, JS; Lingen, MW; Molinolo, A; Squarize, CH, 2013) |
| " Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs." | 1.35 | Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. ( Amornphimoltham, P; Czerninski, R; Gutkind, JS; Molinolo, AA; Patel, V, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (6.45) | 18.2507 |
| 2000's | 6 (19.35) | 29.6817 |
| 2010's | 19 (61.29) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
| Authors | Studies |
|---|---|
| Verma, A | 1 |
| Vincent-Chong, VK | 2 |
| DeJong, H | 2 |
| Hershberger, PA | 3 |
| Seshadri, M | 3 |
| Tan, MT | 1 |
| Wu, JG | 1 |
| Callejas-Valera, JL | 1 |
| Schwarz, RA | 1 |
| Gillenwater, AM | 1 |
| Richards-Kortum, RR | 1 |
| Vigneswaran, N | 2 |
| Cecilio, HP | 1 |
| Valente, VB | 1 |
| Pereira, KM | 1 |
| Kayahara, GM | 1 |
| Furuse, C | 1 |
| Biasoli, ÉR | 1 |
| Miyahara, GI | 1 |
| Oliveira, SHP | 1 |
| Bernabé, DG | 1 |
| Sequeira, I | 1 |
| Rashid, M | 1 |
| Tomás, IM | 1 |
| Williams, MJ | 1 |
| Graham, TA | 1 |
| Adams, DJ | 1 |
| Vigilante, A | 1 |
| Watt, FM | 1 |
| Wang, J | 1 |
| Xie, T | 1 |
| Wang, B | 1 |
| William, WN | 1 |
| Heymach, JV | 1 |
| El-Naggar, AK | 1 |
| Myers, JN | 1 |
| Caulin, C | 1 |
| Rich, LJ | 1 |
| Patti, A | 1 |
| Merzianu, M | 2 |
| Zhao, L | 1 |
| Ma, M | 1 |
| Wu, H | 1 |
| Zhang, C | 1 |
| Dai, S | 1 |
| Dong, P | 1 |
| Huo, B | 1 |
| Shan, B | 1 |
| Kosugi, A | 1 |
| Kasahara, M | 1 |
| Yang, L | 1 |
| Nakamura-Takahashi, A | 1 |
| Shibahara, T | 1 |
| Mori, T | 1 |
| Squarize, CH | 1 |
| Castilho, RM | 1 |
| Abrahao, AC | 1 |
| Molinolo, A | 1 |
| Lingen, MW | 2 |
| Gutkind, JS | 2 |
| Chu, TH | 1 |
| Yang, CC | 1 |
| Liu, CJ | 1 |
| Lui, MT | 1 |
| Lin, SC | 1 |
| Chang, KW | 1 |
| Zhao, J | 1 |
| Wang, Z | 1 |
| Han, J | 1 |
| Qiu, X | 1 |
| Pan, J | 1 |
| Chen, J | 1 |
| Hellebust, A | 1 |
| Rosbach, K | 1 |
| Wu, JK | 1 |
| Nguyen, J | 1 |
| Gillenwater, A | 1 |
| Richards-Kortum, R | 1 |
| Lai, ZL | 1 |
| Tsou, YA | 1 |
| Fan, SR | 1 |
| Tsai, MH | 2 |
| Chen, HL | 1 |
| Chang, NW | 2 |
| Cheng, JC | 1 |
| Chen, CM | 1 |
| Chen, MF | 2 |
| Kuan, FC | 1 |
| Yen, TC | 2 |
| Lu, MS | 1 |
| Lin, PY | 2 |
| Chung, YH | 1 |
| Chen, WC | 2 |
| Lee, KD | 1 |
| Wang, S | 1 |
| Du, Z | 1 |
| Luo, J | 1 |
| Wang, X | 1 |
| Li, H | 1 |
| Liu, Y | 1 |
| Zhang, Y | 1 |
| Ma, J | 1 |
| Xiao, W | 1 |
| Wang, Y | 1 |
| Zhong, X | 1 |
| Abbasi, MM | 1 |
| Jahanban-Esfahlan, R | 1 |
| Monfaredan, A | 1 |
| Seidi, K | 1 |
| Hamishehkar, H | 1 |
| Khiavi, MM | 1 |
| Chen, PT | 1 |
| Hsieh, CC | 1 |
| Wu, CT | 1 |
| Bothwell, KD | 1 |
| Shaurova, T | 1 |
| Suresh, A | 1 |
| Kuriakose, MA | 1 |
| Johnson, CS | 1 |
| Zhong, R | 1 |
| Bao, R | 1 |
| Faber, PW | 1 |
| Bindokas, VP | 1 |
| Bechill, J | 1 |
| Spiotto, MT | 1 |
| Hong, Y | 1 |
| Li, C | 1 |
| Xia, J | 1 |
| Rhodus, NL | 1 |
| Cheng, B | 1 |
| Czerninski, R | 1 |
| Amornphimoltham, P | 1 |
| Patel, V | 1 |
| Molinolo, AA | 1 |
| Pei, RJ | 1 |
| Tseng, HC | 1 |
| Yeh, KT | 1 |
| Chan, HC | 1 |
| Lee, MR | 1 |
| Lin, C | 1 |
| Hsieh, WT | 1 |
| Kao, MC | 1 |
| Lin, CF | 1 |
| Wan, SG | 1 |
| Taccioli, C | 1 |
| Jiang, Y | 1 |
| Chen, H | 1 |
| Smalley, KJ | 1 |
| Huang, K | 1 |
| Liu, XP | 1 |
| Farber, JL | 1 |
| Croce, CM | 1 |
| Fong, LY | 1 |
| Moon, SM | 1 |
| Ahn, MY | 1 |
| Kwon, SM | 1 |
| Kim, SA | 1 |
| Ahn, SG | 1 |
| Yoon, JH | 1 |
| Wali, RK | 1 |
| Kunte, DP | 1 |
| De La Cruz, M | 1 |
| Tiwari, AK | 1 |
| Brasky, J | 1 |
| Weber, CR | 1 |
| Gibson, TP | 1 |
| Patel, A | 1 |
| Savkovic, SD | 1 |
| Brockstein, BE | 1 |
| Roy, HK | 1 |
| Okazaki, Y | 1 |
| Tanaka, Y | 1 |
| Tonogi, M | 1 |
| Yamane, G | 1 |
| Ribeiro, DA | 1 |
| Fávero Salvadori, DM | 1 |
| da Silva, RN | 1 |
| Ribeiro Darros, B | 1 |
| Alencar Marques, ME | 1 |
| Suzuki, R | 1 |
| Kohno, H | 1 |
| Suzui, M | 1 |
| Yoshimi, N | 1 |
| Tsuda, H | 1 |
| Wakabayashi, K | 1 |
| Tanaka, T | 1 |
| Rich, AM | 1 |
| Reade, PC | 1 |
| Nishimura, A | 1 |
| Niwa, S | 1 |
| Ueno, S | 1 |
| Shirasu, R | 1 |
31 other studies available for 4-nitroquinoline-1-oxide and Disease Exacerbation
| Article | Year |
|---|---|
Impact of dietary vitamin D on initiation and progression of oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Calcitriol; Carcinogenesis; Carcinoma, Squamous Cell | 2020 |
A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Class I Phos | 2020 |
Beta-adrenergic blocker inhibits oral carcinogenesis and reduces tumor invasion.
Topics: 4-Nitroquinoline-1-oxide; Adrenergic beta-Antagonists; Animals; Carcinogenesis; Carcinogens; Cytokin | 2020 |
Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogenesis; Carcinoma, Squamous Cell; Disease Mode | 2020 |
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Apoptosis; Carcinogens; CD4-Positive T-Ly | 2017 |
Impact of Age on Disease Progression and Microenvironment in Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Age Factors; Animals; Carcinoma, Squamous Cell; Disease Progression; Femal | 2018 |
p-Hydroxylcinnamaldehyde slows the progression of 4NQO-induced oesophageal tumourigenesis via the RhoA-MAPK signaling pathway.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Cinnamates; Disease Progression; Esophageal Neopl | 2018 |
Method for diagnosing neoplastic lesions by quantitative fluorescence value.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Disease Pr | 2019 |
PTEN deficiency contributes to the development and progression of head and neck cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cells, Cultured; Cycloo | 2013 |
miR-211 promotes the progression of head and neck carcinomas by targeting TGFβRII.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Disease Progression; Genes, myc; Head a | 2013 |
Increased frequency of CD4+ CD25+ FOXP3+ cells correlates with the progression of 4-nitroquinoline1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; CD4 Antigens; Disease Progression; Flow | 2014 |
Vital-dye-enhanced multimodal imaging of neoplastic progression in a mouse model of oral carcinogenesis.
Topics: 4-Chloro-7-nitrobenzofurazan; 4-Nitroquinoline-1-oxide; Algorithms; Animals; Deoxyglucose; Discrimin | 2013 |
Methylation-associated gene silencing of RARB in areca carcinogens induced mouse oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Areca; Arecoline; Carcinogens; Carcinoma, Squamous Cell; Cell Lin | 2014 |
IL-6-stimulated CD11b+ CD14+ HLA-DR- myeloid-derived suppressor cells, are associated with progression and poor prognosis in squamous cell carcinoma of the esophagus.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arginase; Carcinoma, Squamous Cell; Case-Control Studies; CD11b A | 2014 |
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cell T | 2015 |
Oral and IV dosages of doxorubicin-methotrexate loaded- nanoparticles inhibit progression of oral cancer by down- regulation of matrix Methaloproteinase 2 expression in vivo.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protoc | 2014 |
1α,25-Dihydroxyvitamin D3 Inhibits Esophageal Squamous Cell Carcinoma Progression by Reducing IL6 Signaling.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calcitriol; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Prol | 2015 |
Impact of Short-term 1,25-Dihydroxyvitamin D3 on the Chemopreventive Efficacy of Erlotinib against Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antineoplastic Agents; Calcitriol; Carci | 2015 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; | 2015 |
p16(CDKN2A) expression during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cyclin-Dependent Kinase Inhibitor p16; Disease Model | 2009 |
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; alpha-Crystallin B Chain; Animals; Arecoline; Carcinogens; Disease Models, | 2010 |
Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression.
Topics: 4-Nitroquinoline-1-oxide; Animals; Calgranulin A; Carcinogens; Cyclooxygenase 2; Dimethylnitrosamine | 2011 |
Homeobox C5 expression is associated with the progression of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Li | 2012 |
Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Administration, Topical; Animals; Antineoplastic Age | 2012 |
Investigation of environmental factors for diagnosing malignant potential in oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Base Sequence; Biomarkers, Tumor; Carcinogens; Disease | 2002 |
Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Comet | 2004 |
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Animals, Genetically Modified; beta Catenin | 2006 |
Nuclear morphometry in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Nucleus; Cell Transformation, Neoplastic; Disea | 1996 |
Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Carcinoma; Ce | 1999 |
Alteration of pRb expression in the development of rat tongue carcinoma induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Carcinogens; Carcinoma, Squamous Cell; Cyclin | 2001 |