4-nitroquinoline-1-oxide has been researched along with Condition, Preneoplastic in 73 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| " At the termination of the experiment (32 weeks), the incidences of tongue neoplasms and preneoplastic lesions, polyamine levels in the tongue tissue, and cell proliferation activity estimated in terms of 5-bromodeoxyuridine (BrdU)-labeling index and by morphometric analysis of silver-stained nucleolar organizer regions' protein (AgNORs) were compared among the groups." | 3.69 | Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis. ( Hara, A; Kawamori, T; Koshimizu, K; Makita, H; Mori, H; Murakami, A; Ohigashi, H; Ohnishi, M; Satoh, K; Tanaka, T, 1996) |
| "In the 4-NQO model, squamous cell carcinoma, dysplasia, and hyperkeratosis were observed in 75." | 2.87 | Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer. ( El-Naggar, AK; Fan, YH; Feng, L; Foy, JP; Hong, WK; Kim, ES; Lang, W; Lee, JJ; Lingen, MW; Lippman, SM; Mao, L; Papadimitrakopoulou, V; Saintigny, P; William, WN; Zhang, L, 2018) |
| "Oral squamous cell carcinomas (OSCCs) are the most common cancers of the oral cavity, but the molecular mechanisms driving OSCC carcinogenesis remain unclear." | 1.56 | Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma. ( Gudas, LJ; Melis, M; Scognamiglio, T; Zhang, T, 2020) |
| "Oral carcinogenesis involves the progression of the normal mucosa into potentially malignant disorders and finally into cancer." | 1.56 | Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model. ( Chiang, WF; Hsieh, YP; Huang, LY; Huang, TT; Huang, WT; Hwang, DY; Jiang, SS; Liu, KJ; Wang, YY, 2020) |
| "The majority of cases of oral squamous cell carcinoma (OSCC) develop from oral potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation." | 1.48 | Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation. ( Chen, X; Cheng, B; Hu, Q; Wang, C; Wu, T; Xia, J; Yang, L, 2018) |
| "In well-differentiated squamous cell carcinoma induced after 20 weeks of treatment with 4NQO, Wnt1 was expressed in the majority of the dysplasic cells and tumor cells." | 1.36 | Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Fracalossi, AC; Oshima, CT; Ribeiro, DA; Silva, Mde S, 2010) |
| " Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs." | 1.35 | Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. ( Amornphimoltham, P; Czerninski, R; Gutkind, JS; Molinolo, AA; Patel, V, 2009) |
| " We determined that 8 weeks of 100 microg/mL 4-NQO in the drinking water was the optimal dosage and duration to cause a sufficient incidence of hyperkeratoses, dysplasias, and HNSCC over a period of 32 weeks with minimal morbidity and mortality." | 1.35 | ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis. ( Hasina, R; Jalil, A; Jones, CL; Kasza, K; Lingen, MW; Martin, LE, 2009) |
| "The incidence of tongue squamous cell carcinomas (SCC) in the 4-NQO-treated rats was 64%, while that in the rats given ONO-8711 after 4-NQO exposure was 29 (P<0." | 1.34 | A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. ( Fujitsuka, H; Kobayashi, A; Makita, H; Maruyama, T; Miyamoto, S; Mutoh, M; Shibata, T; Suzuki, R; Tanaka, T; Toida, M; Wakabayashi, K; Yasui, Y; Yonemoto, K, 2007) |
| "Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated." | 1.32 | Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Kadota, H; Kakudo, K; Sakaki, T; Tamura, I, 2003) |
| "Squamous cell carcinomas were found in 4 out of 20 rats treated with 514." | 1.30 | Photofrin-mediated photodynamic therapy of chemically-induced premalignant lesions and squamous cell carcinoma of the palatal mucosa in rats. ( Nauta, JM; Nikkels, PG; Roodenburg, JL; Star, WM; van Leengoed, HL; Vermey, A; Witjes, MJ, 1997) |
| " This was based on a dose-response study for normal tissue damage by photodynamic therapy (PDT) in this animal model, because the underlying rationale was to study photo-detection as a method of locating additional (early) malignancies in patients treated by PDT." | 1.30 | In vivo photo-detection of chemically induced premalignant lesions and squamous cell carcinoma of the rat palatal mucosa. ( Nauta, JM; Nikkels, PG; Roodenburg, JL; Speelman, OC; Star, WM; van Leengoed, HL; Vermey, A; Witjes, MJ, 1997) |
| "The dysplastic nevus syndrome (DNS) is a preneoplastic melanocyte abnormality which occurs in families affected by hereditary cutaneous malignant melanoma (HCMM)." | 1.27 | Abnormal responses to the carcinogen 4-nitroquinoline 1-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma. ( Adams, D; Greene, MH; Paterson, MC; Smith, PJ, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (13.70) | 18.7374 |
| 1990's | 23 (31.51) | 18.2507 |
| 2000's | 21 (28.77) | 29.6817 |
| 2010's | 14 (19.18) | 24.3611 |
| 2020's | 5 (6.85) | 2.80 |
| Authors | Studies |
|---|---|
| Neto, JNC | 1 |
| Sorbo, JM | 1 |
| Filho, CAA | 1 |
| Sabino, TFM | 1 |
| Ribeiro, DA | 5 |
| Brunetti, IL | 1 |
| de Andrade, CR | 1 |
| Melis, M | 1 |
| Zhang, T | 1 |
| Scognamiglio, T | 1 |
| Gudas, LJ | 1 |
| Huang, LY | 1 |
| Hsieh, YP | 1 |
| Wang, YY | 1 |
| Hwang, DY | 1 |
| Jiang, SS | 1 |
| Huang, WT | 1 |
| Chiang, WF | 1 |
| Liu, KJ | 1 |
| Huang, TT | 1 |
| Monteiro de Oliveira Novaes, JA | 1 |
| Hirz, T | 1 |
| Guijarro, I | 1 |
| Nilsson, M | 1 |
| Pisegna, MA | 1 |
| Poteete, A | 1 |
| Barsoumian, HB | 1 |
| Fradette, JJ | 1 |
| Chen, LN | 1 |
| Gibbons, DL | 1 |
| Tian, X | 1 |
| Wang, J | 2 |
| Myers, JN | 3 |
| McArthur, MJ | 1 |
| Bell, D | 1 |
| William, WN | 3 |
| Heymach, JV | 2 |
| Shi, Y | 1 |
| Xie, TX | 1 |
| Leach, DG | 1 |
| Wang, B | 2 |
| Young, S | 1 |
| Osman, AA | 1 |
| Sikora, AG | 1 |
| Ren, X | 1 |
| Hartgerink, JD | 1 |
| Rangel, R | 1 |
| Xie, T | 1 |
| El-Naggar, AK | 2 |
| Caulin, C | 1 |
| Chen, X | 2 |
| Hu, Q | 1 |
| Wu, T | 1 |
| Wang, C | 1 |
| Xia, J | 1 |
| Yang, L | 1 |
| Cheng, B | 1 |
| Saintigny, P | 1 |
| Foy, JP | 1 |
| Papadimitrakopoulou, V | 1 |
| Lang, W | 1 |
| Zhang, L | 2 |
| Fan, YH | 1 |
| Feng, L | 1 |
| Kim, ES | 1 |
| Lee, JJ | 1 |
| Mao, L | 1 |
| Hong, WK | 1 |
| Lingen, MW | 2 |
| Lippman, SM | 1 |
| Zhao, L | 1 |
| Ma, M | 1 |
| Wu, H | 1 |
| Zhang, C | 1 |
| Dai, S | 1 |
| Dong, P | 1 |
| Huo, B | 1 |
| Shan, B | 1 |
| Teixeira Buck, MG | 1 |
| Souza Cabral Tuci, P | 1 |
| Perillo Rosin, FC | 1 |
| Pinheiro Barcessat, AR | 1 |
| Corrêa, L | 2 |
| Barcessat, AR | 1 |
| Huang, I | 1 |
| Rabelo, GD | 1 |
| Rosin, FC | 1 |
| Ferreira, LG | 1 |
| de Cerqueira Luz, JG | 1 |
| Noguti, J | 1 |
| Alvarenga, TA | 1 |
| Marchi, P | 1 |
| Oshima, CT | 3 |
| Andersen, ML | 1 |
| Paparella, ML | 1 |
| Abrigo, M | 1 |
| Bal de Kier Joffe, E | 1 |
| Raimondi, AR | 1 |
| Saitoh, T | 1 |
| Sato, K | 2 |
| Tonogi, M | 3 |
| Tanaka, Y | 3 |
| Yamane, GY | 2 |
| Dwivedi, PP | 1 |
| Mallya, S | 1 |
| Dongari-Bagtzoglou, A | 1 |
| Czerninski, R | 1 |
| Amornphimoltham, P | 1 |
| Patel, V | 1 |
| Molinolo, AA | 1 |
| Gutkind, JS | 1 |
| Wilkey, JF | 1 |
| Buchberger, G | 1 |
| Saucier, K | 1 |
| Patel, SM | 1 |
| Eisenberg, E | 1 |
| Nakagawa, H | 1 |
| Michaylira, CZ | 1 |
| Rustgi, AK | 1 |
| Mallya, SM | 1 |
| Hasina, R | 1 |
| Martin, LE | 1 |
| Kasza, K | 1 |
| Jones, CL | 1 |
| Jalil, A | 1 |
| Fracalossi, AC | 2 |
| Silva, Mde S | 1 |
| Farahati, B | 1 |
| Stachs, O | 1 |
| Prall, F | 1 |
| Stave, J | 1 |
| Guthoff, R | 1 |
| Pau, HW | 1 |
| Just, T | 1 |
| Miranda, SR | 1 |
| Franco, M | 1 |
| Sohrabi, M | 1 |
| Soleimani, J | 1 |
| Roshangar, L | 1 |
| Vatansever, S | 1 |
| Arbabi, F | 1 |
| Khaki, AA | 1 |
| Abbasi, MM | 1 |
| Dustar, Y | 1 |
| Javadzadeh, Y | 1 |
| De Costa, AM | 1 |
| Justis, DN | 1 |
| Schuyler, CA | 1 |
| Young, MR | 1 |
| Mendonça, DF | 1 |
| Chammas, R | 1 |
| Liu, FT | 1 |
| Nonogaki, S | 1 |
| Cardoso, SV | 1 |
| Loyola, AM | 1 |
| de Faria, PR | 1 |
| Okazaki, Y | 2 |
| Yamane, G | 1 |
| Tang, ZG | 2 |
| Xu, XP | 2 |
| Sheng, ZH | 1 |
| Liu, SF | 1 |
| Shen, ZH | 1 |
| Yoshida, K | 3 |
| Hirose, Y | 4 |
| Tanaka, T | 17 |
| Yamada, Y | 2 |
| Kuno, T | 1 |
| Kohno, H | 4 |
| Katayama, M | 1 |
| Qiao, Z | 1 |
| Sakata, K | 1 |
| Sugie, S | 3 |
| Shibata, T | 3 |
| Mori, H | 15 |
| Sakaki, T | 1 |
| Tamura, I | 1 |
| Kadota, H | 1 |
| Kakudo, K | 1 |
| Fávero Salvadori, DM | 1 |
| da Silva, RN | 1 |
| Ribeiro Darros, B | 1 |
| Alencar Marques, ME | 1 |
| Yamamoto, K | 1 |
| Kitayama, W | 1 |
| Denda, A | 1 |
| Morisaki, A | 1 |
| Kuniyasu, H | 1 |
| Inoue, M | 1 |
| Kirita, T | 1 |
| Yamaguchi, F | 1 |
| Toida, M | 2 |
| Hara, A | 8 |
| Liu, CG | 1 |
| Jiang, Y | 2 |
| Chatterjee, D | 1 |
| Croce, CM | 1 |
| Huebner, K | 1 |
| Fong, LY | 2 |
| Farber, JL | 1 |
| Choi, Y | 1 |
| Kim, SY | 1 |
| Park, K | 1 |
| Yang, J | 1 |
| Cho, KJ | 1 |
| Kwon, HJ | 1 |
| Byun, Y | 1 |
| Makita, H | 7 |
| Mutoh, M | 1 |
| Maruyama, T | 1 |
| Yonemoto, K | 1 |
| Kobayashi, A | 1 |
| Fujitsuka, H | 2 |
| Miyamoto, S | 1 |
| Yasui, Y | 1 |
| Suzuki, R | 1 |
| Wakabayashi, K | 1 |
| Vairaktaris, E | 1 |
| Goutzanis, L | 1 |
| Kalokerinos, G | 1 |
| Vassiliou, S | 1 |
| Spyridonidou, S | 1 |
| Avgoustidis, D | 1 |
| Strantzias, P | 1 |
| Lazaris, A | 1 |
| Papageorgiou, G | 1 |
| Ragos, V | 1 |
| Yapijakis, C | 1 |
| Patsouris, E | 1 |
| Smith, PJ | 1 |
| Greene, MH | 1 |
| Adams, D | 1 |
| Paterson, MC | 1 |
| Svensson, S | 1 |
| Heyden, G | 2 |
| Ohnishi, M | 3 |
| Tamai, Y | 1 |
| Torihara, M | 1 |
| Yamahara, J | 1 |
| Satoh, K | 5 |
| Wilson, DF | 1 |
| Vreugdenburg, A | 1 |
| Wiebkin, OW | 1 |
| Nauta, JM | 3 |
| Roodenburg, JL | 3 |
| Nikkels, PG | 3 |
| Witjes, MJ | 3 |
| Vermey, A | 3 |
| Wang, A | 1 |
| Ogawa, H | 1 |
| Yamamoto, Y | 1 |
| Itoh, T | 1 |
| Takahashi, H | 1 |
| Kojima, T | 2 |
| Sawada, H | 1 |
| Suzui, M | 1 |
| Yoshimi, N | 1 |
| Navarro, CM | 1 |
| Paes de Almeida, O | 1 |
| Scully, C | 2 |
| Kawamori, T | 1 |
| Murakami, A | 2 |
| Ohigashi, H | 2 |
| Koshimizu, K | 2 |
| Tang, Z | 1 |
| Shen, Z | 1 |
| Liu, S | 1 |
| Rich, AM | 2 |
| Reade, PC | 2 |
| Tatematsu, N | 2 |
| van Leengoed, HL | 2 |
| Star, WM | 2 |
| Speelman, OC | 1 |
| Li, TJ | 1 |
| Hirayama, Y | 1 |
| Kitano, M | 1 |
| Kawabata, K | 4 |
| El-Bayoumy, K | 1 |
| Kakumoto, M | 2 |
| Matsunaga, K | 1 |
| Kuki, W | 1 |
| Takahashi, Y | 1 |
| Yonei, H | 1 |
| Maeda, M | 1 |
| Ota, T | 2 |
| Odashima, S | 1 |
| Ma, G | 2 |
| Ikeda, H | 2 |
| Inokuchi, T | 2 |
| Sano, K | 2 |
| Honjo, S | 2 |
| Ushida, J | 1 |
| Tsuda, H | 2 |
| Murakami, M | 1 |
| Yanaida, Y | 1 |
| Ghosh, BC | 1 |
| Ghosh, L | 1 |
| Newson, BL | 1 |
| Das Gupta, TK | 1 |
| Lekholm, U | 1 |
| Wallenius, K | 2 |
| Morishita, Y | 2 |
| Kitamura, H | 1 |
| Inayama, Y | 1 |
| Shibagaki, T | 1 |
| Hayashi, Y | 1 |
| Tsubakihara, M | 1 |
| Ito, T | 1 |
| Kanisawa, M | 1 |
| Fisker, AV | 1 |
| West, MJ | 1 |
| Philipsen, HP | 1 |
| Andersen, AH | 1 |
| Reibel, J | 1 |
| Dabelsteen, E | 1 |
| Nishikawa, A | 1 |
| Mori, Y | 1 |
| Prime, SS | 1 |
| Malamos, D | 1 |
| Rosser, T | 1 |
| Kuniyasu, T | 1 |
| Shima, H | 1 |
| Takahashi, M | 1 |
| Hirono, I | 1 |
| Takaki, T | 1 |
| Steidler, NE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Study on the Carcinogenesis of SOX-9 in Oral Cancer, and Chemopreventive Possibility for the Treatment of Oral Cancer Using SOX-9 Inhibitor.[NCT01919567] | 255 participants (Anticipated) | Observational | 2011-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 4-nitroquinoline-1-oxide and Condition, Preneoplastic
| Article | Year |
|---|---|
Met Receptor Tyrosine Kinase and Chemoprevention of Oral Cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Squamous Cel | 2018 |
72 other studies available for 4-nitroquinoline-1-oxide and Condition, Preneoplastic
| Article | Year |
|---|---|
Negative terpinen-4-ol modulate potentially malignant and malignant lingual lesions induced by 4-nitroquinoline-1-oxide in rat model.
Topics: 4-Nitroquinoline-1-oxide; Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransf | 2022 |
Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Lineage; Clone Cells; | 2020 |
Single-Cell Analysis of Different Stages of Oral Cancer Carcinogenesis in a Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Arecoline; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Cell L | 2020 |
Targeting of CD40 and PD-L1 Pathways Inhibits Progression of Oral Premalignant Lesions in a Carcinogen-induced Model of Oral Squamous Cell Carcinoma.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; B7-H1 Antigen; Carcinogens; Carcinoma, Sq | 2021 |
Local Anti-PD-1 Delivery Prevents Progression of Premalignant Lesions in a 4NQO-Oral Carcinogenesis Mouse Model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Carcinogenesis; Disease Models, Animal; D | 2021 |
PD-1 Blockade Prevents the Development and Progression of Carcinogen-Induced Oral Premalignant Lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Monoclonal; Apoptosis; Carcinogens; CD4-Positive T-Ly | 2017 |
Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcin | 2018 |
p-Hydroxylcinnamaldehyde slows the progression of 4NQO-induced oesophageal tumourigenesis via the RhoA-MAPK signaling pathway.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Cinnamates; Disease Progression; Esophageal Neopl | 2018 |
Immunohistochemistry profile of p75 neurotrophin receptor in oral epithelial dysplasia and oral squamous cell carcinoma induced by 4-nitroquinoline 1-oxide in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinoma, Squamous Cell; Disease Models, Anim | 2018 |
Systemic toxic effects during early phases of topical 4-NQO-induced oral carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Alanine Transaminase; Animals; Aspartate Aminotra | 2014 |
The influence of sleep restriction on expression of apoptosis regulatory proteins p53, Bcl-2 and Bax following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Prot | 2015 |
Oral-specific ablation of Klf4 disrupts epithelial terminal differentiation and increases premalignant lesions and carcinomas upon chemical carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Diffe | 2015 |
Expression of Cytokeratin 13, 14, 17, and 19 in 4-nitroquinoline-1-oxide-induced Oral Carcinogenesis in Rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Epithelial Cells; Immunohistochemistry; Keratins, Type I; Precanc | 2016 |
A novel immunocompetent murine model for Candida albicans-promoted oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Candida albicans; Candidiasis, Oral; Carcinogens; Disease Models, | 2009 |
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Cyclin D1 overexpression increases susceptibility to 4-nitroquinoline-1-oxide-induced dysplasia and neoplasia in murine squamous oral epithelium.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Northern; Carcinogens; Cell Differentiation; Cell Proli | 2009 |
ABT-510 is an effective chemopreventive agent in the mouse 4-nitroquinoline 1-oxide model of oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Angiogenesis Inhibitors; Animals; Carcinogens; Carcinoma, Squamous Cell; D | 2009 |
Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Carcinogens; Carcinoma, Squamous Cell; Disease Mode | 2010 |
Rigid confocal endoscopy for in vivo imaging of experimental oral squamous intra-epithelial lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma in Situ; Cell Membrane; Cell Nucleus; Dise | 2010 |
The role of matrix metalloproteinases 2 and 9 during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cytoplasm; Immunochemistry; Male; Matrix Metalloproteinase 2; Mat | 2010 |
The effect of dietary and topical celecoxib on 4-nitroquinoline-1-oxide-induced lingual epithelium alternations in rat.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Analysis of Variance; Animals; Celecoxib; Cycloox | 2009 |
Administration of a vaccine composed of dendritic cells pulsed with premalignant oral lesion lysate to mice bearing carcinogen-induced premalignant oral lesions stimulates a protective immune response.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antigens, Neoplasm; Cancer Vaccines; Carcinogens; Carcinoma, Squa | 2012 |
The inactive form of glycogen synthase kinase-3β is associated with the development of carcinomas in galectin-3 wild-type mice, but not in galectin-3-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Nu | 2012 |
Investigation of environmental factors for diagnosing malignant potential in oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Base Sequence; Biomarkers, Tumor; Carcinogens; Disease | 2002 |
The role of cellular trace elements in oral carcinogenesis induced by 4-nitroquinoline 1-oxide(4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Copper; Electron Probe Microanalysis; F | 2000 |
[The electron probe microanalysis on oral precancer treated by garlic].
Topics: 4-Nitroquinoline-1-oxide; Animals; Copper; Drugs, Chinese Herbal; Electron Probe Microanalysis; Epit | 2000 |
Expression of beta-catenin in rat oral epithelial dysplasia induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; beta Catenin; Biomarkers, Tumor; Carcinogens; Cytoskeletal Protei | 2002 |
Inhibitory effects of troglitazone, a peroxisome proliferator-activated receptor gamma ligand, in rat tongue carcinogenesis initiated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Bromodeoxyuridine; Carcinogens; Chromans; | 2003 |
Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogens; Carcinoma, Squamous Cell; Cell Division; | 2003 |
Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Comet | 2004 |
Suppressive effects of a selective cyclooxygenase-2 inhibitor, etodolac, on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Anticarcinogenic Agents; Carcinogens; Carci | 2004 |
Dietary garcinol inhibits 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Carcinogens; Cyclin D1; Cyclooxygenase 2 | 2005 |
Modulation of gene expression in precancerous rat esophagus by dietary zinc deficit and replenishment.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Gene Expression R | 2005 |
Zinc deficiency potentiates induction and progression of lingual and esophageal tumors in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Cyclooxygenase 2; Disease Models, | 2006 |
Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformat | 2006 |
A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animal Feed; Animals; Bridged Bicyclo Compounds; Caproates; Carcinogens; C | 2007 |
Increased risk of oral cancer in diabetic animals is not associated with c-jun activation pathway.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biopsy; Carcinogens; Carcinoma, Squamous Cell; Diabetes Mellitus, | 2007 |
Abnormal responses to the carcinogen 4-nitroquinoline 1-oxide of cultured fibroblasts from patients with dysplastic nevus syndrome and hereditary cutaneous malignant melanoma.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Survival; Cells, Cultured; DNA Repair; DNA Replication; Fi | 1983 |
Experimental induction of irreversible precancerous changes in the palatal epithelium of the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female | 1982 |
Inhibition of 4-nitroquinoline-1-oxide-induced rat oral carcinogenesis by dietary exposure of a new retinoidal butenolide, KYN-54, during the initiation and post-initiation phases.
Topics: 4-Butyrolactone; 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Br | 1995 |
Proteoglycan changes in carcinogen (4NQO)-treated rat tongue mucosa.
Topics: 4-Nitroquinoline-1-oxide; Administration, Topical; Animals; Body Water; Carcinoma; Connective Tissue | 1995 |
Comparison of epithelial dysplasia--the 4NQO rat palate model and human oral mucosa.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Squamous Cell; Chi-Squ | 1995 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene.
Topics: 4-Hydroxyaminoquinoline-1-oxide; 4-Nitroquinoline-1-oxide; Animals; beta Carotene; Carcinoma, Squamo | 1994 |
Assessment of bromodeoxyuridine-labeled S-phase cells in experimentally induced precancerous lesions in the rat's tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bromodeoxyuridine; Carcinoma in Situ; Carcinoma, Squamous Cell; C | 1994 |
Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma; Dose-Response Relationship, Drug; Drug Screening Assay | 1993 |
Infrequent Ha-ras mutations and absence of Ki-ras, N-ras, and p53 mutations in 4-nitroquinoline 1-oxide-induced rat oral lesions.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinoma, Squamous Cell; Exons; Gene Deletion; Ge | 1995 |
Oral focal acantholytic dyskeratosis induced in sialoadenectomized rats painted orally with the carcinogen 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Acantholysis; Animals; Carcinogens; Keratosis; Palate; Precancerous Condit | 1993 |
Chemopreventive effect of a xanthine oxidase inhibitor, 1'-acetoxychavicol acetate, on rat oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Benzyl Alcohols; Biogenic Polyamines; Br | 1996 |
[The effect of topically garlic solution painting on experimental oral precancer and oral cancer in rats].
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents, Phytogenic; Female; Garlic; Male; Mouth Mu | 1995 |
Nuclear morphometry in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Nucleus; Cell Transformation, Neoplastic; Disea | 1996 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Body Weight; Bromod | 1996 |
Photofrin-mediated photodynamic therapy of chemically-induced premalignant lesions and squamous cell carcinoma of the palatal mucosa in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Dis | 1997 |
In vivo photo-detection of chemically induced premalignant lesions and squamous cell carcinoma of the rat palatal mucosa.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Hematoporphyrins; Image En | 1997 |
Glutathione S-transferase pi-class as a tumour marker in lingual preneoplastic and neoplastic lesions of rats and humans.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma in Situ; Carcinoma, Squ | 1997 |
1,4-phenylenebis(methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biomarkers; Carcinogens; Carcinoma, Squa | 1997 |
Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Bromodeoxyuridine; Carcinogens; Coumarin | 1998 |
Effect of photodynamic therapy using 5-aminolevulinic acid on 4-nitroquinoline-1-oxide-induced premalignant and malignant lesions of mouse tongue.
Topics: 4-Nitroquinoline-1-oxide; Aminolevulinic Acid; Animals; Carcinogens; Fluorescent Antibody Technique; | 1999 |
Promotional effects of CO(2) laser and scalpel incision on 4-NQO-induced premalignant lesions of mouse tongue.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; ErbB Receptors; Immunohistochemis | 1999 |
Chemopreventive effect of dietary flavonoid morin on chemically induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Biogenic Polyamines; Diet; Flavonoids; G | 1999 |
Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Body Weight; Carcinogens; Cattle; Epithelium; Glutathione Transfe | 2000 |
Dietary silymarin suppresses 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Apoptosis; Carcinogens; Diet; Dinoprosto | 2002 |
Histochemical and ultrastructural study of lactic dehydrogenase in chemically induced lung cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Newborn; Embryo, Mammalian; Female; Histocytochemistry; | 1978 |
Alterations in the lipid content of rat palatal epithelium during carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma in Situ; Carcinoma, S | 1975 |
Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Antioxidants; Body Weight; Carcinoma, Sq | 1992 |
Preneoplastic changes of xenotransplanted human distal airway epithelium induced by systemic administration of 4-nitroquinoline-1-oxide to host nude mice.
Topics: 4-Nitroquinoline-1-oxide; Aged; Animals; Bronchi; Bronchial Neoplasms; Carcinoembryonic Antigen; Fem | 1991 |
Quantification of oral epithelial hyperplasia in rats after topical application of the carcinogen 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Epithelium; Hyperplasia; Mouth Mucosa; Neoplasms, Experimental; P | 1990 |
Blood group antigen staining pattern during experimental carcinogenesis in rat palate.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blood Group Antigens; Carcinoma, Squamous Cell; Epithelium; Femal | 1988 |
Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Indomethacin; Male; Nitroquinolines; Ornithine Decarboxylase Inhi | 1989 |
Oral epithelial atypia and acantholytic dyskeratosis in rats painted with 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Acantholysis; Animals; Carcinoma, Squamous Cell; Leukoplakia, Oral; Male; | 1986 |
Carcinogenicity of betel quid. III. Enhancement of 4-nitroquinoline-1-oxide- and N-2-fluorenylacetamide-induced carcinogenesis in rats by subsequent administration of betel nut.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Animals; Areca; Chromosome Aberrations; Cocarcinoge | 1986 |
[Cell proliferation in the carcinogenic process of tongue carcinoma in rats induced by 4-nitroquinoline-1-oxide. 2. Relation between morphology, microvascular architecture and cell proliferation in keratinized lesions and squamous cell carcinoma].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Division; Leukoplakia, Oral; Male; | 1986 |
Experimental induction of preneoplastic and neoplastic changes in the lingual mucosa of rats.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Epithelium; Male; Mouth Mucosa; Precanc | 1985 |