4-nitroquinoline-1-oxide has been researched along with Cell Transformation, Neoplastic in 119 studies
4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Human oral cancer is the sixth largest group of malignancies worldwide and single largest group of malignancies in the Indian subcontinent." | 2.43 | 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. ( Kanojia, D; Vaidya, MM, 2006) |
| "Post-treatment with caffeine greatly diminishes the yields by 4NQO of mutants in E." | 2.36 | A test for mutation theory of cancer: carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide. ( Kondo, S, 1977) |
| "Head and neck cancer is the sixth most common malignancy, and there is an urgent need to identify physiological processes contributing to tumorigenesis." | 1.91 | GPR68 limits the severity of chemical-induced oral epithelial dysplasia. ( Amin, ARMR; Graffeo, V; Griggs, N; McAleer, JP; Shore, D; Xu, Y; Zha, XM, 2023) |
| "The majority of cases of oral squamous cell carcinoma (OSCC) develop from oral potentially malignant disorders, which have been confirmed to be involved in chronic oxidative stimulation." | 1.48 | Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation. ( Chen, X; Cheng, B; Hu, Q; Wang, C; Wu, T; Xia, J; Yang, L, 2018) |
| "Head and neck squamous cell carcinoma (HNSCC) development is a multistage process includes the normal, dysplasia and squamous cell carcinoma (SCC) stages." | 1.43 | Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis. ( Cheng, B; Hong, Y; Hu, Q; Jia, L; Wang, J; Wu, J; Wu, T; Xia, J, 2016) |
| "The TGS was able to discriminate oral squamous cell carcinoma (OSCC) from normal oral mucosa in 3 independent datasets." | 1.43 | The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer. ( Bertolus, C; Caulin, C; Chabaud, S; Foy, JP; Goudot, P; Hong, WK; Lachuer, J; Lang, W; Lavergne, E; Le Texier, V; Lippman, SM; Perol, D; Saintigny, P; Thomas, E; Tortereau, A, 2016) |
| "Susceptibly to the induction of rat tongue cancer (TC) by oral 4-nitroquinoline 1-oxide (4NQO) exposure is a polygenic trait." | 1.40 | Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis. ( Ehara, M; Hiai, H; Hirano, M; Kawarada, K; Kitano, M; Muraki, T; Nagayama, M; Shisa, H; Sugimoto, M; Sugiyama, A; Suwa, H; Tanuma, J, 2014) |
| " Furthermore, we show that the inhibition of mTOR by the chronic administration of rapamycin halts the malignant conversion of precancerous lesions and promotes the regression of advanced carcinogen-induced SCCs." | 1.35 | Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model. ( Amornphimoltham, P; Czerninski, R; Gutkind, JS; Molinolo, AA; Patel, V, 2009) |
| "Oral squamous cell carcinoma (SCC) develops from pre-malignant lesions, but the role of cell adhesion molecules such as E-cadherin (E-CD) and P-cadherin (P-CD) in the pre-malignant stage has not been elucidated." | 1.32 | Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. ( Kadota, H; Kakudo, K; Sakaki, T; Tamura, I, 2003) |
| "The papillomas are heterogeneous in their potential for progression to carcinomas, a property apparently induced at the time of initiation." | 1.28 | Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin. ( Hennings, H, 1991) |
| "among rat liver cells untreated, hepatoma cells produced by back-transplantation of rat liver cells after the treatment with a chemical carcinogen in tissue culture, and the hepatoma cells passaged serially through rats." | 1.25 | Carcinogenesis in tissue culture 24: tumorigenicity and aggregate-forming capacity of mammalian cells in culture. ( Akatsuka, T; Katsuta, H; Takaoka, T, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (52.10) | 18.7374 |
| 1990's | 19 (15.97) | 18.2507 |
| 2000's | 16 (13.45) | 29.6817 |
| 2010's | 19 (15.97) | 24.3611 |
| 2020's | 3 (2.52) | 2.80 |
| Authors | Studies |
|---|---|
| He, Y | 1 |
| Rivera, J | 1 |
| Diossy, M | 1 |
| Duan, H | 1 |
| Bowman-Colin, C | 1 |
| Reed, R | 1 |
| Jennings, R | 1 |
| Novak, J | 1 |
| Tran, SV | 1 |
| Cohen, EF | 1 |
| Szuts, D | 1 |
| Giobbie-Hurder, A | 1 |
| Bronson, RT | 1 |
| Bass, AJ | 1 |
| Signoretti, S | 1 |
| Szallasi, Z | 1 |
| Livingston, DM | 1 |
| Pathania, S | 1 |
| Shore, D | 1 |
| Griggs, N | 1 |
| Graffeo, V | 1 |
| Amin, ARMR | 1 |
| Zha, XM | 1 |
| Xu, Y | 1 |
| McAleer, JP | 1 |
| Tan, MT | 1 |
| Wu, JG | 1 |
| Callejas-Valera, JL | 1 |
| Schwarz, RA | 1 |
| Gillenwater, AM | 1 |
| Richards-Kortum, RR | 1 |
| Vigneswaran, N | 1 |
| Chen, X | 2 |
| Hu, Q | 2 |
| Wu, T | 2 |
| Wang, C | 1 |
| Xia, J | 2 |
| Yang, L | 2 |
| Cheng, B | 3 |
| Liu, H | 2 |
| Li, J | 1 |
| Yang, Y | 1 |
| Liu, L | 1 |
| Yu, L | 1 |
| Tu, M | 1 |
| Yuan, R | 1 |
| Yue, W | 1 |
| Luo, Q | 1 |
| Ruan, Y | 2 |
| Dai, X | 2 |
| Zhou, YX | 1 |
| Fuentes-Creollo, G | 1 |
| Ponce, F | 1 |
| Langley, SA | 1 |
| Jen, KY | 1 |
| Celniker, SE | 1 |
| Mao, JH | 1 |
| Snijders, AM | 1 |
| Suwa, H | 1 |
| Hirano, M | 1 |
| Kawarada, K | 1 |
| Nagayama, M | 1 |
| Ehara, M | 1 |
| Muraki, T | 1 |
| Shisa, H | 1 |
| Sugiyama, A | 1 |
| Sugimoto, M | 1 |
| Hiai, H | 1 |
| Kitano, M | 1 |
| Tanuma, J | 1 |
| de Souza, MV | 1 |
| Servato, JP | 1 |
| Loyola, AM | 1 |
| Cardoso, SV | 1 |
| Chammas, R | 1 |
| Liu, FT | 1 |
| Silva, MJ | 1 |
| de Faria, PR | 1 |
| Wang, S | 1 |
| Du, Z | 1 |
| Luo, J | 1 |
| Wang, X | 1 |
| Li, H | 2 |
| Liu, Y | 2 |
| Zhang, Y | 1 |
| Ma, J | 1 |
| Xiao, W | 1 |
| Wang, Y | 2 |
| Zhong, X | 1 |
| Zhong, R | 1 |
| Bao, R | 1 |
| Faber, PW | 1 |
| Bindokas, VP | 1 |
| Bechill, J | 1 |
| Lingen, MW | 1 |
| Spiotto, MT | 1 |
| Zuo, Z | 1 |
| Qin, S | 1 |
| Li, Y | 2 |
| Hong, Y | 2 |
| Jia, L | 1 |
| Wu, J | 1 |
| Wang, J | 2 |
| Foy, JP | 1 |
| Tortereau, A | 1 |
| Caulin, C | 1 |
| Le Texier, V | 1 |
| Lavergne, E | 1 |
| Thomas, E | 1 |
| Chabaud, S | 1 |
| Perol, D | 1 |
| Lachuer, J | 1 |
| Lang, W | 1 |
| Hong, WK | 1 |
| Goudot, P | 1 |
| Lippman, SM | 1 |
| Bertolus, C | 1 |
| Saintigny, P | 1 |
| Czerninski, R | 1 |
| Amornphimoltham, P | 1 |
| Patel, V | 2 |
| Molinolo, AA | 1 |
| Gutkind, JS | 1 |
| Tang, XH | 1 |
| Su, D | 1 |
| Albert, M | 1 |
| Scognamiglio, T | 1 |
| Gudas, LJ | 1 |
| Ghosh, R | 1 |
| Zheng, YF | 1 |
| Chen, ZL | 1 |
| Chen, HB | 1 |
| Cheng, J | 1 |
| Naoi, K | 1 |
| Sunagawa, N | 1 |
| Yoshida, I | 1 |
| Morioka, T | 1 |
| Nakashima, M | 1 |
| Ishihara, M | 1 |
| Fukamachi, K | 1 |
| Itoh, Y | 1 |
| Tsuda, H | 2 |
| Yoshimi, N | 2 |
| Suzui, M | 2 |
| Vered, M | 3 |
| Grinstein-Koren, O | 1 |
| Reiter, S | 1 |
| Allon, I | 2 |
| Dayan, D | 4 |
| Zhang, S | 1 |
| Han, Z | 1 |
| Kong, Q | 1 |
| Sun, B | 1 |
| Wang, G | 1 |
| Mu, L | 1 |
| Wang, D | 1 |
| Fracalossi, AC | 1 |
| Comparini, L | 1 |
| Funabashi, K | 1 |
| Godoy, C | 1 |
| Iwamura, ES | 1 |
| Nascimento, FD | 1 |
| Nader, HB | 1 |
| Oshima, CT | 1 |
| Ribeiro, DA | 3 |
| Yao, R | 1 |
| Gao, S | 1 |
| Wen, W | 1 |
| Du, Y | 1 |
| Szabo, E | 1 |
| Hu, M | 1 |
| Lubet, RA | 2 |
| You, M | 1 |
| Wali, RK | 1 |
| Kunte, DP | 1 |
| De La Cruz, M | 1 |
| Tiwari, AK | 1 |
| Brasky, J | 1 |
| Weber, CR | 1 |
| Gibson, TP | 1 |
| Patel, A | 1 |
| Savkovic, SD | 1 |
| Brockstein, BE | 1 |
| Roy, HK | 1 |
| Lobikin, M | 1 |
| Chernet, B | 1 |
| Lobo, D | 1 |
| Levin, M | 1 |
| Feith, DJ | 1 |
| Pegg, AE | 1 |
| Fong, LY | 1 |
| Ohkoshi, A | 1 |
| Suzuki, T | 1 |
| Ono, M | 2 |
| Kobayashi, T | 1 |
| Yamamoto, M | 1 |
| Tsutsui, T | 1 |
| Kumakura, S | 1 |
| Yamamoto, A | 1 |
| Kanai, H | 1 |
| Tamura, Y | 1 |
| Kato, T | 1 |
| Anpo, M | 1 |
| Tahara, H | 1 |
| Barrett, JC | 2 |
| Sakaki, T | 1 |
| Tamura, I | 1 |
| Kadota, H | 1 |
| Kakudo, K | 1 |
| Fávero Salvadori, DM | 1 |
| da Silva, RN | 1 |
| Ribeiro Darros, B | 1 |
| Alencar Marques, ME | 1 |
| Yarom, N | 1 |
| Suzuki, R | 1 |
| Kohno, H | 1 |
| Wakabayashi, K | 1 |
| Tanaka, T | 1 |
| Kanojia, D | 1 |
| Vaidya, MM | 1 |
| Choi, Y | 1 |
| Kim, SY | 1 |
| Park, K | 1 |
| Yang, J | 1 |
| Cho, KJ | 1 |
| Kwon, HJ | 1 |
| Byun, Y | 1 |
| Li, C | 1 |
| Xia, H | 1 |
| Rhodus, NL | 1 |
| Buchner, A | 1 |
| Yamamoto, K | 1 |
| Kitayama, W | 1 |
| Denda, A | 1 |
| Sasahira, T | 1 |
| Kuniyasu, H | 1 |
| Kirita, T | 1 |
| Kitakawa, D | 1 |
| Domingues, MA | 1 |
| Cabral, LA | 1 |
| Marques, ME | 1 |
| Salvadori, DM | 1 |
| Maltzman, W | 1 |
| Czyzyk, L | 1 |
| Kakunaga, T | 4 |
| Leavitt, J | 1 |
| Hamada, H | 1 |
| Nishitani, K | 2 |
| Namba, M | 9 |
| Kimoto, T | 2 |
| Le François-Chabas, D | 1 |
| Montagnier, L | 2 |
| Watanabe, M | 1 |
| Cupido, M | 1 |
| Simons, JW | 1 |
| Kuroki, T | 1 |
| Smith, BL | 1 |
| Sager, R | 1 |
| Clegg, JC | 1 |
| Glatt, HR | 1 |
| Oesch, F | 1 |
| Peterkofsky, B | 3 |
| Prather, W | 2 |
| Miyaki, M | 2 |
| Akamatsu, N | 2 |
| Ono, T | 1 |
| Tonomura, A | 1 |
| Utsunomiya, J | 2 |
| Oshiro, Y | 1 |
| Balwierz, PS | 1 |
| Parshad, R | 1 |
| Gantt, R | 1 |
| Sanford, KK | 1 |
| Jones, GM | 1 |
| Tarone, RE | 2 |
| Bouck, N | 2 |
| di Mayorca, G | 1 |
| Svensson, S | 1 |
| Heyden, G | 1 |
| Katoh, Y | 4 |
| Takayama, S | 3 |
| O'Donovan, MR | 1 |
| Sato, K | 1 |
| Hama-Inaba, H | 1 |
| Shiomi, T | 1 |
| Kondo, T | 5 |
| Mihara, K | 6 |
| Inoue, Y | 1 |
| Iijima, M | 5 |
| Naniwa, M | 1 |
| Kano, Y | 1 |
| Kawashima, K | 1 |
| Usuki, H | 1 |
| Shimizu, N | 1 |
| Jahan, I | 2 |
| Bai, L | 1 |
| Donnelly, MJ | 1 |
| Yeudall, WA | 1 |
| Game, SM | 2 |
| Scully, C | 4 |
| Prime, SS | 4 |
| Tsuji, T | 1 |
| Ishioka, C | 1 |
| Rich, AM | 2 |
| Reade, PC | 2 |
| Kandarkar, SV | 1 |
| Sawant, SS | 1 |
| Kino, K | 1 |
| Fushimi, K | 1 |
| Gao, C | 1 |
| Shima, T | 1 |
| Townsend, AJ | 1 |
| Fields, WR | 1 |
| Haynes, RL | 1 |
| Doss, AJ | 1 |
| Doehmer, J | 1 |
| Morrow, CS | 1 |
| Nishimura, A | 1 |
| Kaplan, I | 1 |
| Engelberg, J | 1 |
| Daniel, MR | 1 |
| Dehnel, JM | 1 |
| Altanerová, V | 1 |
| Takaoka, T | 1 |
| Katsuta, H | 1 |
| Akatsuka, T | 1 |
| Chang, KS | 1 |
| Price, PJ | 1 |
| Auletta, AE | 1 |
| King, MP | 1 |
| Hugunin, PM | 1 |
| Huebner, RJ | 1 |
| Sekiya, S | 1 |
| Kuwata, T | 1 |
| Hata, RI | 1 |
| Niwa, O | 1 |
| Sugahara, T | 1 |
| Waters, R | 1 |
| Mishra, N | 1 |
| DiMayorca, G | 1 |
| Regan, JD | 1 |
| Mishra, NK | 2 |
| Pant, KJ | 1 |
| Wilson, DM | 1 |
| Thomas, FO | 1 |
| Kondo, S | 1 |
| Ishii, Y | 1 |
| Elliott, JA | 1 |
| Lieberman, MW | 1 |
| Miyazawa, T | 1 |
| Umeda, M | 1 |
| Hiss, EA | 1 |
| Preston, RJ | 1 |
| Ikenaga, M | 1 |
| Tökés, ZA | 1 |
| Sorgente, N | 1 |
| Ahlström, U | 1 |
| Mark, J | 1 |
| Stein, GH | 1 |
| Nagao, M | 1 |
| Sugimura, T | 2 |
| Popescu, NC | 1 |
| DiPaolo, JA | 1 |
| Stopper, H | 1 |
| Pechan, R | 1 |
| Schiffmann, D | 1 |
| Mello, ML | 1 |
| Vidal, Bde C | 1 |
| Golembieski, W | 1 |
| Russo, J | 2 |
| Hennings, H | 1 |
| Lefrançois, D | 1 |
| Kokalj, N | 1 |
| Viegas-Péquignot, E | 1 |
| Dutrillaux, B | 1 |
| Nataatmadja, MI | 1 |
| Gebhardt, BM | 1 |
| Salmeron, B | 1 |
| McDonald, MB | 1 |
| Stone, A | 2 |
| Rhim, JS | 1 |
| Fujita, J | 1 |
| Arnstein, P | 1 |
| Aaronson, SA | 1 |
| Yasutake, C | 1 |
| Kuratomi, Y | 1 |
| Masumi, S | 1 |
| Kuwano, M | 1 |
| Crane, IJ | 1 |
| Luker, J | 1 |
| de Gay, L | 1 |
| Rice, SQ | 1 |
| Cornelis, JJ | 1 |
| Becquart, P | 1 |
| Duponchel, N | 1 |
| Salomé, N | 1 |
| Avalosse, BL | 1 |
| Rommelaere, J | 1 |
| Sato, C | 1 |
| Hiwasa, T | 1 |
| Tanigawara, C | 1 |
| Sakiyama, S | 1 |
| Miao, RM | 1 |
| Tanga, MJ | 1 |
| Suk, WA | 1 |
| Miller, A | 1 |
| Reist, EJ | 1 |
| Schechtman, LM | 1 |
| Hatch, GG | 1 |
| Anderson, TM | 1 |
| Putman, DL | 1 |
| Kouri, RE | 1 |
| Cameron, JW | 1 |
| Nims, RW | 1 |
| Spalding, JW | 1 |
| Tennant, RW | 1 |
| Takaki, T | 1 |
| Bem, WT | 1 |
| Christensen, B | 1 |
| Kieler, J | 1 |
| Kersch, RL | 1 |
| Thilly, WG | 1 |
| Hashimoto, Y | 2 |
| Kawachi, E | 2 |
| Shudo, K | 2 |
| Sekiya, T | 2 |
| Rosser, TJ | 1 |
| Davies, LS | 1 |
| Chu, KC | 1 |
| Brown, CC | 1 |
| Tan, WY | 1 |
| de Campos Vidal, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics Study of Antitumor B in Healthy Volunteers[NCT04230057] | 12 participants (Actual) | Observational | 2019-12-12 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for 4-nitroquinoline-1-oxide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
4-nitroquinoline-1-oxide induced experimental oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Tr | 2006 |
[In Search of the mechanism of neoplastic cell transformation--the current confused state].
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; DNA; | 1983 |
In vitro carcinogenesis by 4-nitroquinoline 1-oxide and related compounds.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Carcinogens; Cell Cycle; Cell Transformation, Neoplasti | 1981 |
[Ultraviolet light-sensitive mutants and radiomimetic substance-sensitive mutants of cultured mammalian cells].
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cell | 1982 |
[Aging and immortalization of human cells].
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Sene | 1994 |
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Transformation, Neoplastic; Cytological Techniques; Fibrob | 1993 |
A test for mutation theory of cancer: carcinogenesis by misrepair of DNA damaged by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Transformation, Neoplastic; DNA; DNA Repair; DNA, | 1977 |
Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Animals; Bacteria; Bacteriophages; Base Sequence; Carcinogens; Ce | 1976 |
111 other studies available for 4-nitroquinoline-1-oxide and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Topics: 4-Nitroquinoline-1-oxide; Animals; BRCA1 Protein; Cell Line, Tumor; Cell Transformation, Neoplastic; | 2021 |
GPR68 limits the severity of chemical-induced oral epithelial dysplasia.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinoma, Squamous Cell; Cell Transformation, Ne | 2023 |
A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Proliferation; Cell Transformation, Neoplastic; Class I Phos | 2020 |
Proteomics-based investigation of multiple stages of OSCC development indicates that the inhibition of Trx-1 delays oral malignant transformation.
Topics: 4-Nitroquinoline-1-oxide; Adult; Aged; Animals; Apoptosis; Biomarkers, Tumor; Carcinogenesis; Carcin | 2018 |
Alterations of 63 hub genes during lingual carcinogenesis in C57BL/6J mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogenesis; Carcinogens; Carcinoma, Squamo | 2018 |
No difference in 4-nitroquinoline induced tumorigenesis between germ-free and colonized mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogenesis; Carcinogens; Carcinoma, Squamous Cell; Cell Trans | 2019 |
Pthlh, a promising cancer modifier gene in rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; Gene | 2014 |
Expression of APC protein during tongue malignant transformation in galectin-3-deficient mice challenged by the carcinogen 4-nitroquniline-n-oxide.
Topics: 4-Nitroquinoline-1-oxide; Adenomatous Polyposis Coli Protein; Animals; Carcinogens; Carcinoma; Cell | 2014 |
Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Proliferation; Cell T | 2015 |
Notch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Breast Neoplasms; Carcinogens; | 2015 |
[Study on lingual mucosa carcinogenesis of C57BL/6 mice induced by 4-nitroquinoline 1-oxide].
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Mice; Mi | 2015 |
Modulation of IL-1β reprogrammes the tumor microenvironment to interrupt oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; | 2016 |
The dynamics of gene expression changes in a mouse model of oral tumorigenesis may help refine prevention and treatment strategies in patients with oral cancer.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinogens; Carcinoma, Squamous Cell; Cel | 2016 |
Targeting mammalian target of rapamycin by rapamycin prevents tumor progression in an oral-specific chemical carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibiotics, Antineoplastic; Carcinogens; Carcinoma, Squamous Cel | 2009 |
Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen.
Topics: 4-Nitroquinoline-1-oxide; Acyltransferases; Animals; Carcinogens; Cell Transformation, Neoplastic; C | 2009 |
Lecithin:retinol acyltransferase and retinyl esters: is balance the essence in carcinogenesis?
Topics: 4-Nitroquinoline-1-oxide; Acyltransferases; Animals; Carcinogens; Cell Transformation, Neoplastic; E | 2009 |
[Expression of survivin, Bcl-2 and p53 during 4-nitro-quinoline 1-oxide-induced rat tongue carcinogenesis].
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; Cell Transformation, Neoplastic; Genes, bcl-2; Male; M | 2009 |
Enhancement of tongue carcinogenesis in Hras128 transgenic rats treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Drug S | 2010 |
The effect of desalivation on the malignant transformation of the tongue epithelium and associated stromal myofibroblasts in a rat 4-nitroquinoline 1-oxide-induced carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Actins; Animals; Carcinoma; Cell Proliferation; Cell Transformation, Neopl | 2010 |
Malignant transformation of rat bone marrow-derived mesenchymal stem cells treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cell | 2010 |
Ras gene mutation is not related to tumour invasion during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Actins; Animals; Cell Transformation, Neoplastic; Genes, ras; Ki-67 Antige | 2011 |
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Benzoxepins; Biomar | 2013 |
Topical polyethylene glycol as a novel chemopreventive agent for oral cancer via targeting of epidermal growth factor response.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Administration, Topical; Animals; Antineoplastic Age | 2012 |
Resting potential, oncogene-induced tumorigenesis, and metastasis: the bioelectric basis of cancer in vivo.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blood Vessels; Body Patterning; Carcinogens; Cell Transformation, | 2012 |
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Proliferation; Cell Transformation | 2013 |
Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Adaptor Proteins, Signal Transducing; Animals; Cell Transformation, Neopla | 2013 |
Association of p16(INK4a) and pRb inactivation with immortalization of human cells.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxin B1; Carcinogens; Cell Cycle; Cell Line; Cell Transformation, Neo | 2002 |
Changing expression of E- and P-cadherin during rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cadherins; Carcinogens; Carcinoma, Squamous Cell; Cell Division; | 2003 |
Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Comet | 2004 |
4NQO oral carcinogenesis: animal models, molecular markers and future expectations.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biomarkers, Tumor; Carcinogens; Carcinoma, Squamous Cell; Cell Tr | 2005 |
An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies.
Topics: 4-Nitroquinoline-1-oxide; Administration, Oral; Animals; Animals, Genetically Modified; beta Catenin | 2006 |
Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Transformat | 2006 |
Frequent mutation of p16(CDKN2A) exon 1 during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Carcinogens; Cell Transformation, Neoplastic; DNA; | 2007 |
Stromal myofibroblasts and malignant transformation in a 4NQO rat tongue carcinogenesis model.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Transformation, Neopl | 2007 |
Expression of receptor for advanced glycation end products during rat tongue carcinogenesis by 4-nitroquinoline 1-oxide and effect of a selective cyclooxygenase-2 inhibitor, etodolac.
Topics: 4-Nitroquinoline-1-oxide; Animals; Anticarcinogenic Agents; Cell Transformation, Neoplastic; Cycloox | 2006 |
Survivin and inducible nitric oxide synthase production during 4NQO-induced rat tongue carcinogenesis: a possible relationship.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Immunohistochemistry; Male; Micr | 2007 |
UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Kinetics; Mice; | 1984 |
A mutation in actin associated with neoplastic transformation.
Topics: 4-Nitroquinoline-1-oxide; Actins; Amino Acid Sequence; Cell Line; Cell Transformation, Neoplastic; D | 1984 |
Lactate dehydrogenase isozyme patterns of normal human fibroblasts and their in vitro-transformed counterparts obtained by treatment with CO-60 gamma-rays, SV40 or 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Cell Transformation, Neoplastic; Cobalt Radioisotopes; Embryo, Mammalian; | 1981 |
[Supertransformation of a human lymphoblastoid cell line by chemical carcinogens].
Topics: 4-Nitroquinoline-1-oxide; Animals; Ataxia Telangiectasia; Burkitt Lymphoma; Carcinogens; Cell Line; | 1983 |
A re-appraisal of the BHK 21 clone-13 cell transformation system with respect to the assay conditions and the mutational origin of the transformed phenotype.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Count; Cell Line; Cell Transformation, Neoplastic; Cricetina | 1984 |
Multistep origin of tumor-forming ability in Chinese hamster embryo fibroblast cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cricetulu | 1982 |
Coordinate mutation and transformation of mouse fibroblasts: induction by nitroquinoline oxide and modulation by caffeine.
Topics: 4-Nitroquinoline-1-oxide; Animals; Caffeine; Cell Transformation, Neoplastic; Cells, Cultured; Drug | 1981 |
Correlation between the rates of aerobic glycolysis and glucose transport, unrelated to neoplastic transformation, in a series of BALB 3T3-derived cell lines.
Topics: 4-Nitroquinoline-1-oxide; Animals; Biological Transport; Cell Division; Cell Line; Cell Transformati | 1982 |
Morphologic transformation and chromosomal changes induced by chemical carcinogens in skin fibroblasts from patients with familial adenomatosis coli.
Topics: 4-Nitroquinoline-1-oxide; Adenoma; Cell Count; Cell Division; Cell Transformation, Neoplastic; Cells | 1982 |
Morphological transformation of C3H/10T1/2 CL8 cells by procarcinogens.
Topics: 2-Acetylaminofluorene; 2-Naphthylamine; 4-Nitroquinoline-1-oxide; Aflatoxin B1; Aflatoxins; Animals; | 1982 |
Repair of chromosome damage induced by X-irradiation during G2 phase in a line of normal human fibroblasts and its malignant derivative.
Topics: 4-Nitroquinoline-1-oxide; Caffeine; Catalase; Cell Line; Cell Transformation, Neoplastic; Chromosome | 1982 |
Chemical carcinogens transform BHK cells by inducing a recessive mutation.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; Cr | 1982 |
Experimental induction of irreversible precancerous changes in the palatal epithelium of the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Female | 1982 |
Conversion of platelet-derived growth factor-dependent cells to growth factor-independent cells during chemical carcinogenesis in vitro.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Culture M | 1982 |
Some factors influencing the behavior of BHK 21 Cl 13 cells in soft agar medium.
Topics: 4-Nitroquinoline-1-oxide; Agar; Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Cul | 1982 |
Two-dimensional electrophoretic analysis of down-regulated proteins in human fibroblasts immortalized by treatment with either 4-nitroquinoline 1-oxide or 60Co gamma rays.
Topics: 4-Nitroquinoline-1-oxide; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cobalt Radioisoto | 1995 |
Transfected mutant p53 gene increases X-ray-induced cell killing and mutation in human fibroblasts immortalized with 4-nitroquinoline 1-oxide but does not induce neoplastic transformation of the cells.
Topics: 4-Nitroquinoline-1-oxide; Animals; Base Sequence; Cell Death; Cell Division; Cell Line, Transformed; | 1995 |
Karyotypic analysis in the process of immortalization of human cells treated with 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Cell Transformation, Neoplastic; Cells, Cultured; Cellular Senescence; Chr | 1995 |
Autocrine production of TGF-alpha and TGF-beta during tumour progression of rat oral keratinocytes.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Western; Cell Division; Cell Line; Cell Transformation, | 1993 |
Mutation in p53 and de-regulation of p53-related gene expression in three human cell lines immortalized with 4-nitroquinoline 1-oxide or 60Co gamma rays.
Topics: 4-Nitroquinoline-1-oxide; Base Sequence; Blotting, Northern; Carcinogens; CDC2 Protein Kinase; Cell | 1996 |
Nuclear morphometry in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Nucleus; Cell Transformation, Neoplastic; Disea | 1996 |
The effect of vitamin C on the hamster cheek pouch treated with the water soluble carcinogen 4-nitroquinoline-1-oxide (4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Ascorbic Acid; Carcinogens; Cell Transformation, Neoplastic; Chee | 1996 |
Immortalization of mutant p53-transfected human fibroblasts by treatment with either 4-nitroquinoline 1-oxide or X-rays.
Topics: 4-Nitroquinoline-1-oxide; Animals; Blotting, Southern; Blotting, Western; Cell Line, Transformed; Ce | 1997 |
Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection.
Topics: 4-Nitroquinoline-1-oxide; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Alkylation; Animals; C | 1998 |
Changes in Bcl-2 and Bax expression in rat tongue during 4-nitroquinoline 1-oxide-induced carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Apoptosis; bcl-2-Associated X Protein; Carcinogens; Carcinoma; Ce | 1999 |
The effect of desalivation on 4-nitroquinoline-1-oxide-induced tongue carcinogenesis: a morphometric study of nucleolar organizer regions.
Topics: 4-Nitroquinoline-1-oxide; Analysis of Variance; Animals; Carcinogens; Cell Transformation, Neoplasti | 2001 |
Factors affecting the performance of the styles cell transformation test.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; Agar; Animals; Benzo(a)pyrene; Biotransformation; B | 1980 |
Transformation of BHK 21/13 cells by chemical carcinogens and mutagens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzopyrenes; Carcinogens; Cell Line; Cell Transform | 1975 |
The progressive nature of neoplastic transformation of Syrian hamster embryo cells in culture.
Topics: 4-Nitroquinoline-1-oxide; Animals; Benzopyrenes; Cell Transformation, Neoplastic; Cells, Cultured; C | 1979 |
Carcinogenesis in tissue culture 24: tumorigenicity and aggregate-forming capacity of mammalian cells in culture.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinoma, Hepatocellular; Cell Aggregation; Cell Nucleolus; Cell | 1975 |
Susceptibility of xeroderma pigmentosum cells to transformation by murine and feline sarcoma viruses.
Topics: 4-Nitroquinoline-1-oxide; Age Factors; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; | 1976 |
The co-carcinogenic activity of 4-nitropyridine-1-oxide (4-NPO) and prevention of transformation by type-specific anti-viral antibodies.
Topics: 4-Nitroquinoline-1-oxide; Animals; Antibodies, Viral; Cell Line; Cell Transformation, Neoplastic; Co | 1976 |
Transformation of hamster embryo cells by Rous sarcoma virus and 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cu | 1976 |
Specific changes in the collagen phenotype of BALB 3T3 cells as a result of transformation by sarcoma viruses or a chemical carcinogen.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Transformation, Neoplastic; Collagen; Contact Inhibition; | 1977 |
Radiation induction of endogenous type C virus from mouse cells transformed in vitro by murine sarcoma virus.
Topics: 4-Nitroquinoline-1-oxide; Bromodeoxyuridine; Cell Transformation, Neoplastic; Clone Cells; Dose-Resp | 1979 |
Partial inhibition of postreplication repair and enhanced frequency of chemical transformation in rat cells infected with leukemia virus.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Line; Cell Transformation, Neoplastic; DNA; DNA Repair; Dose | 1977 |
Carcinogen-induced mutations at two separate genetic loci are not enhanced by leukaemia virus infection.
Topics: 4-Nitroquinoline-1-oxide; Azaguanine; Cell Transformation, Neoplastic; Drug Resistance; Genes; Mutat | 1977 |
Quantitative studies of transformation by chemical carcinogens and ultraviolet radiation using a subclone of BHK21 clone 13 Syrian hamster cells.
Topics: 4-Nitroquinoline-1-oxide; Acetoxyacetylaminofluorene; Animals; Carcinogens; Cell Line; Cell Survival | 1977 |
Establishment and characteristics of three mouse cell lines from embryos of different inbred strains.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Benzopyrenes; Cell Division; Ce | 1977 |
Transformation and neoplastic development of hamster chondrocytes after exposure to 4-nitroquinoline-1-oxide and 3-methylcholanthrene in tissue culture.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cartilage; Cell Differentiation; Cell Division; Cell Transformati | 1977 |
The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatment.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Transformation, Neoplastic; Cytarabine; DNA; DNA Repair; G | 1977 |
Excision of 4-nitroquinoline 1-oxide damage and transformed in mouse cells.
Topics: 4-Nitroquinoline-1-oxide; Adenine; Cell Transformation, Neoplastic; Cells, Cultured; DNA Repair; DNA | 1977 |
Carcinogenesis in tissue culture. 28. Comparison of various effects of a chemical carcinogen, 4-nitroquinoline I-oxide, on normal human cells and on normal mouse cells in culture.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; | 1977 |
Proteolysis associated with normal, carcinogen-treated, and transformed rat liver epithelial cells.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Membrane; Cell Transformation, Neoplastic; Kinetics; Liver | 1977 |
Quantitative studies on in vitro transformation of hamster chondrocytes.
Topics: 4-Nitroquinoline-1-oxide; Animals; Animals, Newborn; Cartilage; Cell Differentiation; Cell Transform | 1978 |
Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cell | 1978 |
Cytogenetic analysis of oral and cutaneous squamous cell carcinomas in the rat.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Carcinoma, Squamous Cell; Cell | 1975 |
Caffeine inhibits cell transformation by 4-nitroquinoline-1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Caffeine; Cell Line; Cell Transformation, Neoplastic; DNA Repair; Dose-Res | 1975 |
Differences in DNA-binding proteins isolate from normal and transformed human cells.
Topics: 4-Nitroquinoline-1-oxide; Cell Division; Cell Line; Cell Transformation, Neoplastic; Contact Inhibit | 1976 |
Premature chromosome condensation and chromosome despiralization in Syrian hamster cells transformed in vitro.
Topics: 4-Nitroquinoline-1-oxide; Aflatoxins; Benzopyrenes; Cell Line; Cell Transformation, Neoplastic; Chro | 1976 |
In vitro transformation of hamster chondrocytes by 4-nitroquinoline 1-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cartilage; Cell Transformation, Neoplastic; Cells, Cultured; Cric | 1976 |
5-azacytidine induces micronuclei in and morphological transformation of Syrian hamster embryo fibroblasts in the absence of unscheduled DNA synthesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Cell Transformation, Neoplastic; Cells, Cultured; Cr | 1992 |
Image analysis of Feulgen-stained NIH/3T3 cells transformed with DNA of 4-nitroquinoline 1-oxide treated human breast epithelial cells.
Topics: 3T3 Cells; 4-Nitroquinoline-1-oxide; Animals; Breast; Cell Line, Transformed; Cell Nucleus; Cell Tra | 1992 |
Malignant conversion, the first stage in progression, is distinct from phorbol ester promotion in mouse skin.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Acetone; Animals; Carcinoma, Squamous Ce | 1991 |
High recurrence of rearrangements involving chromosome 14 in an ataxia telangiectasia lymphoblastoid cell line and in its mutagen-treated derivatives.
Topics: 4-Nitroquinoline-1-oxide; Adult; Antigens, Viral; Ataxia Telangiectasia; Cell Line, Transformed; Cel | 1991 |
Basal cell nuclear size in experimental oral mucosal carcinogenesis.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Nucleus; Cell Transformation, Neoplastic; Male; Mouth Mucosa | 1991 |
Effect of excimer laser energy on the growth potential of corneal keratocytes.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Differentiation; Cell Division; Cell Transformation, Neoplas | 1990 |
Tumour progression in experimental oral carcinogenesis is associated with changes in EGF and TGF-beta receptor expression and altered responses to these growth factors.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cells, | 1990 |
Neoplastic conversion of human keratinocytes by adenovirus 12-SV40 virus and chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Adenoviruses, Human; Animals; Cell Line; Cell Transformation, Neoplastic; | 1986 |
Effect of 5-azacytidine on malignant transformation of a mutant derived from the mouse BALB/c 3T3 cell line resistant to transformation by chemical carcinogens.
Topics: 4-Nitroquinoline-1-oxide; Animals; Azacitidine; Benzo(a)pyrene; Cell Line; Cell Transformation, Neop | 1987 |
Transformation of oral keratinocytes in vitro by 4-nitroquinoline N-oxide.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Epidermal Cells | 1988 |
Transformation of human fibroblasts by ionizing radiation, a chemical carcinogen, or simian virus 40 correlates with an increase in susceptibility to the autonomous parvoviruses H-1 virus and minute virus of mice.
Topics: 4-Nitroquinoline-1-oxide; Cell Line; Cell Transformation, Neoplastic; Disease Susceptibility; DNA Re | 1988 |
Chemical and viral transformation of cultured skin fibroblasts from patients with familial polyposis coli.
Topics: 4-Nitroquinoline-1-oxide; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Chromosom | 1988 |
Defects of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in initiated clones derived from BALB/c 3T3 mouse fibroblasts.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Division; Cell Line; Cell Transformation, Neoplastic; Clone | 1987 |
Potential carcinogenicity of aza-aromatic hydrocarbons: azabenz(a)anthracenes.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Animals; Aza Compounds; Benz(a)Anthracen | 1986 |
Analysis of the interlaboratory and intralaboratory reproducibility of the enhancement of simian adenovirus SA7 transformation of Syrian hamster embryo cells by model carcinogenic and noncarcinogenic compounds.
Topics: 2-Acetylaminofluorene; 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adenoviridae; Ade | 1986 |
[Cell proliferation in the carcinogenetic processes of tongue carcinoma induced by 4-nitroquinoline-1-oxide in rats. 1. Relation between morphology and microvascular architecture of the filiform papillae of dorsal surface of the tongue in normal albino ra
Topics: 4-Nitroquinoline-1-oxide; Animals; Arterioles; Carcinoma; Cell Division; Cell Transformation, Neopla | 1986 |
Suppression of synthesis of pro-alpha 1(I) and production of altered pro-alpha 2(I) procollagen subunits in 4-nitroquinoline-1-oxide-transformed fibroblasts.
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Collagen; Crice | 1986 |
Unscheduled DNA synthesis related to transformation grade of human urothelial cells.
Topics: 4-Nitroquinoline-1-oxide; Autoradiography; Carcinogens; Cell Line; Cell Transformation, Neoplastic; | 1987 |
Internal standards for survival: increasing the accuracy for human cell mutation assays.
Topics: 4-Nitroquinoline-1-oxide; Adenine Phosphoribosyltransferase; B-Lymphocytes; Cell Line; Cell Survival | 1987 |
Activation of c-Ha-ras proto-oncogene by in vitro chemical modification with 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1) and 4-nitroquinoline N-oxide (4NQO).
Topics: 4-Nitroquinoline-1-oxide; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Humans; Imidazo | 1986 |
Transforming activity of human c-Ha-ras-1 proto-oncogene generated by the binding of 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole and 4-nitroquinoline N-oxide: direct evidence of cellular transformation by chemically modified DNA.
Topics: 4-Nitroquinoline-1-oxide; Base Sequence; Cell Line; Cell Transformation, Neoplastic; Codon; DNA; Hum | 1987 |
Loss of epithelial cell surface carbohydrates during experimental oral carcinogenesis in the rat.
Topics: 4-Nitroquinoline-1-oxide; Animals; Carbohydrate Metabolism; Carcinoma, Squamous Cell; Cell Membrane; | 1987 |
Differentiating among proposed mechanisms for tumor promotion in mouse skin with the use of the multievent model for cancer.
Topics: 4-Nitroquinoline-1-oxide; Acetone; Animals; Cell Transformation, Neoplastic; Mathematics; Mice; Mode | 1987 |
Nuclear phenotypical changes of human breast epithelial cells treated with carcinogens.
Topics: 4-Nitroquinoline-1-oxide; 9,10-Dimethyl-1,2-benzanthracene; Adult; Breast; Cell Nucleolus; Cell Nucl | 1987 |